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Chromatography and modification of nucleosides. Part A, Analytical methods for major and modified nucleosides, HPLC, GC, MS, NMR, UV, and FT-IR /

Chromatography and Modification of Nucleosides is a four-volume work which provides state-of-the-art chromatography and analytical methods for use in a wide spectrum of nucleic acid modification research. The focus of Part A, is the presentation of advanced methods for modification research on tRNAs...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Gehrke, Charles W., Kuo, Kenneth C. T., 1936-
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Amsterdam ; New York : New York, NY, U.S.A. : Elsevier ; Distributors for the U.S. and Canada Elsevier Science Pub. Co., 1990.
Colección:Journal of chromatography library ; v. 45A.
Temas:
Acceso en línea:Texto completo
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MARC

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245 0 0 |a Chromatography and modification of nucleosides.  |n Part A,  |p Analytical methods for major and modified nucleosides, HPLC, GC, MS, NMR, UV, and FT-IR /  |c edited by Charles W. Gehrke and Kenneth C.T. Kuo. 
246 3 0 |a Analytical methods for major and modified nucleosides, HPLC, GC, MS, NMR, UV, and FT-IR 
260 |a Amsterdam ;  |a New York :  |b Elsevier ;  |a New York, NY, U.S.A. :  |b Distributors for the U.S. and Canada Elsevier Science Pub. Co.,  |c 1990. 
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490 1 |a Journal of chromatography library,  |x 0301-4770 ;  |v v. 45A 
504 |a Includes bibliographical references and indexes. 
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520 |a Chromatography and Modification of Nucleosides is a four-volume work which provides state-of-the-art chromatography and analytical methods for use in a wide spectrum of nucleic acid modification research. The focus of Part A, is the presentation of advanced methods for modification research on tRNAs, mRNAs, mtRNAs, rRNAs and DNAs. HPLC-UV, GC-MS, NMR, FT-IR and affinity chromatography approaches to nucleic acid modification studies are presented, as are nucleoside, oligonucleotide and nucleic acid isolation techniques. Part B has as its central theme the modified nucleosides of tRNA and the current analytical means for studying tRNA modifications. Modified nucleoside synthesis, function, structural conformation, biological regulation, and occurrence of modification in a wide range of tRNAs are presented, as is a chapter on DNA modification and a chapter on solid phase immunoassay for determining a particular modification. Part C provides the reader with a comprehensive treatment of modified nucleosides as biochemical signals of neoplasia and normal metabolism. The final volume, Part D, will present structural characterization of unknown nucleosides as well as extensive biochemical, chemical and physical properties of RNA and DNA nucleosides, as a "database" for researchers in the field. Chromatographic methodology will be described for analysis of total modification of tRNAs and DNAs. The chapters are written by leading scientists in their respective fields and present an up-to-date review on the roles of modified nucleosides in nucleic acids which will be extremely useful for workers in chromatography, molecular biology, genetics, biochemistry, biotechnology and the pharmaceutical industry 
505 0 |a Front Cover; Chromatography and Modification of Nucleosides; Copyright Page; Table of Contents; Preface; A Didication and Thanks; Special Acknowledgement; Editors; Contributors; Chromatography and Modification of Nucleosides: Contents of Parts B, C and D; Introduction and Overview; Chapter 1. Ribonucleoside Analysis by Reversed-phase High Performance Liquid Chromatography; Chapter 2. HPLC of Transfer RNAs using Ionic-Hydrophobic Interaction Chromatography; Chapter 3. Nucleic Acid Chromatographic Isolation and Sequence Methods. 
505 8 |a Chapter 4. Affinity Chromatography of Mammalian tRNAS on Immobilized Elongation Factor Tu from Themus thermophilusChapter 5. Structural Elucidation of Nucleosides in Nucleic Acids; Chapter 6. Three Dimensional Dynamic Structure of Trnsfer RNA by Nuclear Magentic Resonance Spectroscopy; Chapter 7. Codon Recognition: Evaluation of the Effects of Modified Bases in the Anticodon Loop of tRNA Using the Temperature-Jump Relaxation Method; Chapter 8. High Performance Liquid Chromatography of Cap Structures and Nucleoside Composition in mRNAs-297. 
505 8 |a Chapter 9. Immunoassays for Modified Nucleosides of Ribonucleic AcidsChapter 10. Chromatography of Synthetic and Natural Oligonucleotides; Subject Index; Journal of Chromatography Library (series). 
650 0 |a Nucleosides  |x Metabolism. 
650 0 |a Nucleosides  |x Derivatives  |x Synthesis. 
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700 1 |a Gehrke, Charles W. 
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776 0 8 |i Print version:  |t Chromatography and modification of nucleosides. Part A, Analytical methods for major and modified nucleosides, HPLC, GC, MS, NMR, UV, and FT-IR.  |d Amsterdam ; New York : Elsevier ; New York, NY, U.S.A. : Distributors for the U.S. and Canada Elsevier Science Pub. Co., 1990  |z 0444885404  |z 9780444885401  |w (DLC) 89025973  |w (OCoLC)20595774 
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