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Advances in immunology. Volume 60
This volume highlights the latest reviews of mechanisms and actions of the immune system and the host response to infection and inflammation. Key Features * Covers cytokine functioning as influenced by the Janus protein tyrosine kinase family * Explores immunodeficiencies, including: * Immunoglobuli...
| Clasificación: | Libro Electrónico |
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| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
New York :
Academic Press,
�1995.
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| Colección: | Advances in immunology.
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| Temas: | |
| Acceso en línea: | Texto completo Texto completo |
Tabla de Contenidos:
- Front Cover; Advances in Immunology, Volume 60; Copyright Page; Contents; Contributors; Chapter 1. The Janus Protein Tyrosine Kinase Family and Its Role in Cytokine Signaling; I. Introduction; II. Origins and Structure of the Janus Kinases; III. Janus Kinases Couple Cytokine Binding to Induction of Tyrosine Phosphorylation; IV. The Role of Receptor Dimerization/Oligomerization in Activation of Janus Kinases; V. Association of Jaks with Cytokine Receptors Occurs through the Membrane Proximal Domains; VI. Activation of the ras Signaling Pathway by Cytokine Receptors.
- VII. Cytokines Induce Increases in Phosphatidylinositol (PI)-3 Kinase ActivityVIII. Insulin-Receptor Substitute 1 (IRS-1) and 4PS: Signal Transducers Phosphorylated in Response to Cytokines; IX. Vav: A Common Substrate of Cytokine-Induced Tyrosine Phosphorylation; X. Signal Transducers and Activators of Transcription Stats: A Novel Family of Transcription Factors Identified in Interferon Signaling; XI. Stats: A Common Theme in Cytokine Signding; XII. Mechanisms of Stat Recruitment to Cytokine Receptor Complexes; XIII. Stat Proteins Regulate a Variety of Genes in Hematopietic Cells.
- XIV. Negative Regulation of Cytokine Signaling by Tyrosine PhosphatasesXV. Jaks and Stats in Other Receptor Systems; XVI. Summary and Conclusions; References; Chapter 2. X-Linked Agammaglobulinemia and Immunoglobulin Deficiency with Normal or Elevated IgM: Immunodeficiencies of B Cell Development and Differentiation; I. Introduction; II. B Cell Development and Differentiation; III. XLA: A Defect of B Cell Development; IV. HIGMX-1: A Defect of B Cell Differentiation; V. Conclusion and Future Prospects; References.
- Chapter 3. Defective Glycosyl Phosphatidylinositol Anchor Synthesis and Paroxysmal Nocturnal HemoglobinuriaI. Introduction; II. The GPI Anchor and the GPI-Anchored Proteins; III. Paroxysmal Nocturnal Hemoglobinuria (PNH); IV. Perspectives and Conclusions; References; Chapter 4. The Use of Multiple Antigen Peptides in the Analysis and Induction of Protective Immune Responses against Infectious Diseases; I. Multiple Antigen Peptides; II. MAPs as Immunogens in Protozoan Diseases; III. MAPS as Immunogens in Helminthic Diseases; IV. MAPS as Immunogens in Viral and Bacterial Diseases.
- V. MAPs as AntigensVI. Conclusions; References; Chapter 5. Eosinophils: Biology and Role in Disease; I. Biology of the Eosinophil; II. Eosinophils and Parasites; III. Eosinophils and Disease; IV. Final Conclusions; References; Chapter 6. In Situ Studies of the Germinal Center Reaction; I. Introduction; II. Histology of the Spleen; III. The Germinal Center Reaction; IV. Somatic Hypermutation, Selection, and the Generation of Immunological Memory; V. Germinal Centers and Other Microenvironments for Diversification; VI. Conclusions; References.