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Gap junctions : molecular basis of cell communication in health and disease /
Since the first gap junction protein (connexin) was cloned over a decade ago, more than a dozen connexin genes have been cloned. Consequently, a wealth of information on the molecular basis of gap junctional communication has been accumulated. This book pays tribute to this exciting era in the histo...
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
San Diego :
Academic Press,
�2000.
|
| Colección: | Current topics in membranes ;
v. 49. |
| Temas: | |
| Acceso en línea: | Texto completo Texto completo |
MARC
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| 050 | 4 | |a QH601 |b .C84eb vol. 49 | |
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| 245 | 0 | 0 | |a Gap junctions : |b molecular basis of cell communication in health and disease / |c edited by Camillo Peracchia. |
| 260 | |a San Diego : |b Academic Press, |c �2000. | ||
| 300 | |a 1 online resource (xxvii, 648 pages) : |b illustrations | ||
| 336 | |a text |b txt |2 rdacontent | ||
| 337 | |a computer |b c |2 rdamedia | ||
| 338 | |a online resource |b cr |2 rdacarrier | ||
| 490 | 1 | |a Current topics in membranes ; |v v. 49 | |
| 504 | |a Includes bibliographical references and index. | ||
| 588 | 0 | |a Print version record. | |
| 520 | |a Since the first gap junction protein (connexin) was cloned over a decade ago, more than a dozen connexin genes have been cloned. Consequently, a wealth of information on the molecular basis of gap junctional communication has been accumulated. This book pays tribute to this exciting era in the history of cell communication research by documenting the great strides made in this field as a result of the merging of biophysics and molecular biology, two of the most powerful approaches to studying the molecular basis of membrane channel behavior. Twenty-eight comprehensive chapters, authored by internationally recognized leaders in the field, discuss the biophysical, physiological, and molecular characteristics of cell-to-cell communication via gap junctions. Key aspects of molecular structure, formation, gating, conductance, and permeability of vertebrate and invertebrate gap junction channels are highlighted. In addition, a number of chapters focus on recent discoveries that implicate connexin mutations and alterations of gap junctional communication in the pathogenesis of several diseases, including the X-linked Charcot Marie Tooth demyelinating disease, some forms of inherited sensorineural deafness, malignant transformation, cardiac malformations and arrhythmia, eye lens cataract, and Chagas' disease. | ||
| 505 | 0 | |a Front Cover; Gap Junctions: Molecular Basis of Cell Communication in Health and Disease; Copyright Page; Contents; Contributors; Preface; Previous Volumes in Series; Part I: Channel Structure, Assembly, and Degradation; Chapter 1. Gap Junction Structure: New Structures and New Insights; I. Overview of Gap Junction Structure; II. The Constituent Proteins of Gap Junctions: Size and Topology Models of the Connexin Family; III. Isolation and Purification of Gap Junctions; IV. Molecular Structure of Gap Junctions Determined by X-Ray Diffraction and Electron Microscopy; V. Concluding Remarks. | |
| 505 | 8 | |a II. Homotypic hCx37 and rCx43 Gap Junction ChannelsIII. Hetcrotypic hCx37-rCx43 Gap Junction Channels; IV. Co-transfection of hCx37 and rCx43: Heteromcric Gap Junction Channels; V. Why Would a Cell Bother with Heteromeric Gap Junction Channels?; References; Chapter 4. Heteromultimeric Gap Junction Channels and Cardiac Disease; I. Introduction; II. Gap Junctions: Structure and Nomenclature; III. Endogenous Expression of Multiple Connexins in Various Tissues; IV. Experimental Formation of Heteromultimeric Channels in Exogenous Systems; V. Molecular Regions Involved in Assembly. | |
| 505 | 8 | |a VI. Physiological Implications of Heteromultimeric Channel FormationVII. Conclusions and Future Directions; Rcferences; Chapter 5. Ion Permeation through Connexin Gap Junction Channels: Effects on Conductance and Selectivity; I. Introduction; II. Theories of Electrodiffusion; III. Gap Junction Channel Conductance and Permeability; IV. Summary; References; Chapter 6. Phosphorylation of Connexins: Consequences for Permeability, Conductance, and Kinetics of Gap Junction Channels; I. Introduction; II. Connexin43; III. Connexin40 and -45; IV. Connexin26 and -32; V. Concluding Remarks; References. | |
| 505 | 8 | |a Chapter 7. Intercellular Calcium Wave Communication via Gap Junction-Dependent and -Independent MechanismsI. Introduction; II. Two Routes for Intercellular Calcium Wave Propagation; III. Some Features of Intercellular Ca2+ Waves Depend upon the Initiating Stimulus; IV. Mechanisms for Intercellular Ca2+ Wave Propagation; V. How Connexins Can Potentially Influence and Modulate the Propagation of Intercellular Ca2+ Waves; VI. How the Extracellular Space May Influence Calcium Wave Propagation; VII. Functional Roles of Intercellular Calcium Waves; VIII. Prospects; References. | |
| 546 | |a English. | ||
| 650 | 0 | |a Gap junctions (Cell biology) | |
| 650 | 0 | |a Cell interaction. | |
| 650 | 0 | |a Connexins. | |
| 650 | 1 | 2 | |a Gap Junctions |x physiology |0 (DNLM)D017629Q000502 |
| 650 | 2 | |a Gap Junctions |0 (DNLM)D017629 | |
| 650 | 2 | |a Cell Communication |0 (DNLM)D002450 | |
| 650 | 2 | 2 | |a Connexins |0 (DNLM)D017630 |
| 650 | 6 | |a Jonctions communicantes (Biologie cellulaire) |0 (CaQQLa)201-0221274 | |
| 650 | 6 | |a Cellules |x Interaction. |0 (CaQQLa)201-0005047 | |
| 650 | 6 | |a Connexines. |0 (CaQQLa)201-0287006 | |
| 650 | 7 | |a SCIENCE |x Life Sciences |x Cell Biology. |2 bisacsh | |
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| 650 | 7 | |a Connexins |2 fast |0 (OCoLC)fst00875361 | |
| 650 | 7 | |a Gap junctions (Cell biology) |2 fast |0 (OCoLC)fst00937740 | |
| 650 | 1 | 7 | |a Celbiologie. |2 gtt |
| 650 | 1 | 7 | |a Interactie. |2 gtt |
| 650 | 1 | 7 | |a Ziekten. |2 gtt |
| 700 | 1 | |a Peracchia, Camillo. | |
| 776 | 0 | 8 | |i Print version: |t Gap junctions. |d San Diego : Academic Press, �2000 |z 0121533492 |z 9780121533496 |w (DLC) 2001278560 |w (OCoLC)43311416 |
| 830 | 0 | |a Current topics in membranes ; |v v. 49. | |
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