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Nitric oxide : biochemistry, molecular biology, and therapeutic implications /
Each volume of Advances in Pharmacology provides a rich collection of reviews on timely topics. Emphasis is placed on the molecular bases of drug action, both applied and experimental. This volume contains chapters that address diverse but interrelated areas pertaining to the chemistry, biochemistry...
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | , |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
San Diego :
Academic Press,
�1995.
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| Colección: | Advances in pharmacology (San Diego, Calif.) ;
vol. 34. |
| Temas: | |
| Acceso en línea: | Texto completo Texto completo Texto completo |
Tabla de Contenidos:
- Front Cover; Nitric Oxide: Biochemistry, Molecular Biology, and Therapeutic Implications; Copyright Page; Contents; Contributors; Chapter 1. Chemistry of Nitric Oxide: Biologically Relevant Aspects; I. Introduction; II. Physical and Chemical Properties of NO; III. Reaction of NO with Oxygen; IV. Reaction of NO with Superoxide; V. Chemistry of NO-Derived Nitrogen Oxides; VI. Reactions of NO and NO2 with Thiols; VII. Reaction of NO with Amines; VIII. Reaction of NO with Heme Proteins and Metals; IX. Reaction of NO with Oxyhemoglobin and Oxymyoglobin; X. Summary; References.
- Chapter 2. Reactions between Nitric Oxide, Superoxide, and Peroxynitrite: Footprints of Peroxynitrite in VivoI. Introduction; II. Target Areas for Reactive Species; III. Reactions of Nitric Oxide and Rationale for Product Analysis in Vivo; IV. Oxidative Pathology and the Search for Footprints; V. Phenolic Reaction Products in Vivo: Stable and Specific Footprints of ONOO-; Chapter 3. Oxygen Radical-Nitric Oxide Reactions in Vascular Diseases; I. Introduction; II. Prooxidant versus Tissue-Protective Reactions of .NO; II. NO-Oxygen Radical Interactions in Atherosclerosis.
- III. NO-Oxygen Radical Interactions in Transplant Vasculopathy and RestenosisIV. NO-Oxygen Radical Interactions in Reperfusion Injury; V. Conclusions; References; Chapter 4. Nitric Oxide Synthases: Gene Structure and Regulation; I. Overview; II. nNOS; III. iNOS; IV. ecNOS; V. Summary; References; Chapter 5. Transcription of the Human Neuronal Nitric Oxide Synthase Gene in the Central Nervous System Is Mediated by Multiple Promoters'; I. Perspective: Relationship of NOS1 Gene Expression Studies to Other Aspects of Nitric Oxide Biochemistry, Molecular Biology, and Physiology.
- II. An Interesting Genomic Structure Underpins Expression of NOS1 in the CNSIII. Expression of NOS2 -Reporter Gene Constructs in Transfection Systems; lV. Discussion; References; Chapter 6. Regulation of the Expression of the Inducible lsoform of Nitric Oxide Synthase; l. Nitric Oxide; II. NOSs; III. Regulation of iNOS Induction by Endogenous Glucocorticoids; IV. Polyamines as Inhibitors of the Induction of iNOS: Role of Oxidized Aldehyde Metabolites; V. Regulation of iNOS Induction by Cytokines; VI. Cellular Mechanisms of the Induction of iNOS; VII. Therapeutic Implications; References.
- Chapter 7. Regulation and Function of Inducible Nitric Oxide Synthase during Sepsis and Acute InflammationI. Introduction; II. Regulation of iNOS Gene Expression; III. Posttranslational Regulation of Induced NO Synthesis; IV. Cellular Actions of NO; V. Role of NO in Acute Sepsis and Inflammation; VI. NO in Chronic Inflammation; VII. NOS Inhibitors and Therapeutic Implications; VIII. Summary; References; Chapter 8. Expression and Expressional Control of Nitric Oxide Synthases in Various Cell Types; I. Introduction; II. NOS Nomenclatures; III. Cellular Distribution of NOS Isoforms.