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Conjugation-dependent carcinogenicity and toxicity of foreign compounds /
Each volume of Advances in Pharmacology provides a rich collection of reviews on timely topics. Emphasis is placed on the molecular basis of drug action, both applied and experimental. Conjugation reactions have long been associated with the detoxification of xenobiotics. Recent studies suggest that...
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | , |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
San Diego :
Academic Press,
�1994.
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| Colección: | Advances in pharmacology ;
v. 27. |
| Temas: | |
| Acceso en línea: | Texto completo Texto completo |
Tabla de Contenidos:
- Front Cover; Conjugation-Dependent Carcinogenicity and Toxicity of Foreign Compounds; Copyright Page; Contents; Contributors; Chapter 1. Historical Perspectives on Conjugation-Dependent Bioactivation of Foreign Compounds; I. Metabolic Research Leading to Conjugation-Dependent Bioactivation of 4-Dimethylaminoazobenzene and 2-Acetylaminofluorene; II. Important Observations Leading to Bioactivation of Foreign Compounds via Glutathione Conjugation, Methylation, and Epoxide Formation and Hydrolysis; References; Part I: Glutathione-Dependent Toxicity.
- Chapter 1. Enzymology of Microsomal Glutathione S-TransferaseI. Introduction; II. Catalysis; III. Activation; IV. The Activated Enzyme; V. Thiol Substrates; VI. Concluding Remarks; References; Chapter 2. Enzymology of Cytosolic Glutathione S-Transferases; I. Introduction; II. The GST Supergene Family; III. Structure of GSTs Including Their Active Sites; IV. Enzyme Kinetics; V. Gene Structure and Gene Regulation; VI. Specific Examples Illustrating the Properties of GSTs; VII. Conclusions; References; Chapter 3. Enzymology of Cysteine S-Conjugate �-Lyases; I. Introduction.
- II. Enzymes That Cleave the Thioether Bond of S-Substituted CysteinesIII. Bacterial Cysteine S-Conjugate �-Lyases; IV. Mammalian Cysteine S-Conjugate �-Lyases; V. Design of Prodrugs Directed toward Glutamine K/Cysteine S-Conjugate �-Lyase in the Kidney; Vl. Conclusions; Note Added in Proof; References; Chapter 4. Formation and Fate of Nephrotoxic and Cytotoxic Glutathione S-Conjugates: Cysteine Conjugate �-Lyase Pathway; I. Introduction; II. Biosynthesis of Toxic Glutathione S-Conjugates; III. Fate of S-Conjugates; IV. Bioactivation of Cytotoxic and Nephrotoxic Cysteine S-Conjugates.
- v. Cellular Effects of Cytotoxic and Nephrotoxic Cysteine S-ConjugatesReferences; Chapter 5. Reversibility in Glutathione-Conjugate Formation; I. Introduction; II. Classes of Compounds That Undergo Reversible Conjugation; III. Conclusions; References; Chapter 6. Glutathione Conjugation as a Mechanism for the Transport of Reactive Metabolites; I. Introduction; II. Glutathione Conjugation as a Mechanism for the Transport of Redox Active Compounds; III. Transport of Glutathione-Conjugated Redox Compounds to the Kidney as a Common Factor in Chemical-Induced Nephrocarcinogenicity.
- IV.?-Glutamyltranspeptidase and the Toxicity of Glutathione-Conjugated Redox CompoundsV. Targeting of Glutathione Conjugates to Neoplastic Tissues Expressing g-Glutamyltranspeptidase; VI. Developmental Toxicity o f Glutathione-Conjugated Redox Compounds; VII. Transport of Reversible Glutathione Conjugates; VIII. Glutathione, Nitric Oxide, and Endothelial-Derived Relaxing Compounds; IX. Summary; References; Chapter 7. Metabolism and Genotoxicity of Dihaloalkanes; I. Introduction; II. Adducts Derived from 1,2-Dihaloethanes; III. Other Dihaloalkanes.