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Advances in cancer research. Volume 62. /
This latest volume of the biannual serial continues rapid, current coverage of all aspects of the molecular basis of human cancer, functions of oncogenes, and research strategies for cancer drug development and treatment. Topics reviewed in Volume 62 include chromosomes and cancer; pathways in Ras f...
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | , |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
San Diego :
Academic Press,
�1993.
|
| Colección: | Advances in cancer research ;
v. 62 |
| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Cover; Contents; Contributors to Volume 62; Chapter 1. Foundations in Cancer Research-Chromosomes and Cancer: The Evolution of an Idea; I. Introduction; II. Boveri and Early Studies (Before 1950); III. The Stemline Concept and Modern Cytogenetics (the 1950s); IV. Early Findings in the Pre-banding Era (the 1960s); V. Chromosome Banding and Clonal Evolution (the 1970s); VI. Molecular Cytogenetics (the 1980s); VlI. Conclusions; References; Chapter 2. Pathways of Ras Function: Connections to the Actin Cytoskeleton; I. Introduction; II. Ras Guanine Nucleotide Exchange Factors
- III. GAP and GAP-Associated ProteinsIV. Signal Transduction Pathways Downstream of Ras; V. Perspectives on Ras Function; References; Note Added in Proof; Chapter 3. The Role of the Adenomatous Polyposis Coli (APC) Gene in Human Cancers; I. Identification of the APC Gene; II. Germline Mutations of the APC Gene in Familial Adenomatous Polyposis Patients; III. Somatic Mutations of the APC Gene in Colorectal Tumors; IV. Somatic Mutations of the APC Gene in Other Human Cancers; References; Chapter 4. Molecular Cytogenetics of Renal Cell Tumors; I. Introduction
- II. Differential Genetics of Renal Cell TumorsIII. Genetics of Nonpapillary Renal Cell Carcinomas; IV. Genetics of Papillary Renal Cell Tumors; V. Renal Oncocytoma; VI. Chromophobe Renal Cell Carcinoma; VII. Conclusions; References; Chapter 5. Reverse Transformation, Genome Exposure, and Cancer; I. Introduction; II. Review of Reverse Transformation (Redifferentiation); III. The Genome Exposure Defect in Cancer; IV. Restoration of Genome Exposure in Transformed Cells; V. Differentiation Induction in Malignant Cells as Reverse Transformation
- VI. Relationship to Other Work on DNase I SensitivityVII. Theoretical Formulation about Signal Transduction Mechanisms Governing Genome Exposure; VIII. Further Unsolved Problems and Some Experimental Predictions of the Model; IX. Therapeutic and Preventative Significance; X. Summary; References; Chapter 6. Peptide-Binding Heat Shock Proteins in the Endoplasmic Reticulum: Role in Immune Response to Cancer and in Antigen Presentation; I. The Curious Paradox of Heat Shock Proteins as Tumor-Specific Antigens; II. Hypothesis That HSPs Chaperone Antigenic Peptides
- III. Evidence in Support of the HypothesisIV. Mechanisms by Which HSPs Elicit Specific Immunity; V. Implications for Immunity to Cancer; VI. Implications for Antigen Presentation; References; Chapter 7. The Association of Epstein-Barr Virus (EBV) with T Cell Lymphoproliferations and Hodgkin's Disease: Two New Developments in the EBV Field; I. Introduction; II. Biology of EBV; III. Detection of EBV Markers in Tissues; IV. EBV and T Cell Lymphoproliferations; V. EBV and Hodgkin's Disease; References