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Eukaryotic transcription factors /
Transcription, or the process by which DNA produces RNA, is a central aspect of gene expression. Transcription factors regulate transcription during development and in disease states. As such, it is critical for researchers to gain a good understanding of the relationship between the structure of va...
| Clasificación: | Libro Electrónico |
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| Autor principal: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Amsterdam ; Boston :
Elsevier/Academic Press,
2008.
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| Edición: | 5th ed. |
| Temas: | |
| Acceso en línea: | Texto completo |
| Sumario: | Transcription, or the process by which DNA produces RNA, is a central aspect of gene expression. Transcription factors regulate transcription during development and in disease states. As such, it is critical for researchers to gain a good understanding of the relationship between the structure of various families of transcription factors and their function, as well as roles in human disease. Since publication of the Fourth Edition, there have been major advances, notably in the areas of chromatin remodeling and genome-scale analyses. This complete update includes all new coverage of the latest developments, from enabling genomic technologies to studies on the importance of post-translational modifications beyond phosphorylation events. Brand new coverage in this edition includes: * Potential of transcription factors as therapeutic targets in human disease * Importance of histone modifications * Use of genome-based sequence analysis and high-throughput methods * Applications of the chromatin immunoprecipitation (ChIP) assay * Transcriptional elongation * Regulation by post-translational modifications * Regulatory networks and bioinformatics. |
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| Descripción Física: | 1 online resource (xxviii, 471 pages) : illustrations (some color) |
| Bibliografía: | Includes bibliographical references and index. |
| ISBN: | 9780123739834 0123739837 9780080561035 0080561039 1281189022 9781281189028 9786611189020 6611189025 |