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Advances in cancer research. Volume 91 /
The Advances in Cancer Research series provides invaluable information on the exciting and fast-moving field of cancer research. This volume presents outstanding and original reviews on a variety of topics including.
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | , |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Amsterdam ; Boston :
Elsevier/Academic Press,
�2004.
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| Colección: | Advances in cancer research ;
91 |
| Temas: | |
| Acceso en línea: | Texto completo Texto completo |
Tabla de Contenidos:
- Front Cover; Advances in Cancer Reasearch; Copyright Page; Contents; Contributors to Volume 91; Chapter 1. Imatinib as a Paradigm of Targeted Therapies; I. Introduction; II. Identification of the BCR-ABL Tyrosine Kinase as a Therapeutic Target; III. Development of an ABL-Specific Tyrosine Kinase Inhibitor; IV. Clinical Trials in CML; V. Mechanisms of Relapse; VI. Structural Basis of ABL Inhibition by Imatinib; VII. Activity of Imatinib in Other Indications; VIII. Lessons Learned from the Clinical Trials of Imatinib; IX. Translating the Success of Imatinib to Other Malignancies; References
- Chapter 2. Prostate Cancer and the Met Hepatocyte Growth Factor ReceptorI. Hepatocyte Growth Factor/Scatter Factor-Met and Stromal-Epithelial Interactions in the Prostate; II. Met in Localized Prostate Cancer; III. Met in Prostate Cancer Metastasis; IV. Therapeutic Implications of Met Expression in Prostate Cancer; References; Chapter 3. Keratinocyte Growth Factor/Fibroblast Growth Factor 7, a Homeostatic Factor with Therapeutic Potential for Epithelial Protection and Repair; I. Introduction; II. Molecular Biology of KGF; III. Cellular and Molecular Responses to KGF; IV. Signal Transduction
- v. Transgenic and Knockout ModelsVI. Regenerative and Protective Effects; VII. Clinical Trials. Amelioration of Severe Oral Mucositis; VIII. Concluding Remarks; References; Chapter 4. Histone Deacetylase Inhibitors; I. Chromatin Structure; II. Histone Deacetylases and Histone Acetyltransferases; III. Histone Deacetylases/Histone Acetyltransferases and Human Cancers; IV. Histone Deacetylase Inhibitors; V. Activity of Histone Deacetylase Inhibitors; VI. Clinical Trials with Histone Deacetylase Inhibitors; VII. Conclusions and Perspectives; References
- Chapter 5. Raf-1 Kinase Inhibitor Protein. Structure, Function, Regulation of Cell Signaling, and Pivotal Role in ApoptosisI. Introduction. The Phosphatidylethanolamine-Binding Protein Family; II. Raf-1 Kinase Inhibitor Protein; III. Sigficance of rkip in Cancer; IV. Concluding Remarks; References; Index