Separation methods in drug synthesis and purification /

Mostrar otras versiones (1)

Separation Methods in Drug Synthesis and Purification.

Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Valk�o, Kl�ara
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Amsterdam ; New York : Elsevier, 2000.
Colección:Handbook of analytical separations ; v. 1.
Temas:
Drugs > Analysis.
Drug development.
Separation (Technology)
Pharmaceutical chemistry.
Chemistry, Pharmaceutical > methods
Chemistry, Analytical > methods
Pharmaceutical Preparations > isolation & purification
Chemistry, Pharmaceutical
M�edicaments > Analyse.
M�edicaments > D�eveloppement.
S�eparation (Technologie)
Chimie pharmaceutique.
MEDICAL > Drug Guides.
MEDICAL > Pharmacology.
MEDICAL > Pharmacy.
MEDICAL > Nursing > Pharmacology.
Drug development
Drugs > Analysis
Pharmaceutical chemistry
Internet Resources.
Acceso en línea:Texto completo
Texto completo
Texto completo
Tabla de Contenidos:
  • Front Cover
  • Separation Methods in Drug Synthesis and Purification
  • Copyright Page
  • Contents
  • Editor's Preface
  • Series Editor's Preface
  • List of Contributors
  • Chapter 1. Comparison of various modes and phase systems for analytical HPLC
  • 1.1 Fundamentals of HPLC
  • 1.2 Chromatographic column and column packing particles
  • 1.3 Separation modes in HPLC
  • 1.4 Method development and optimisation of conditions in isocratic HPLC
  • 1.5 Development of gradient-elution separations
  • 1.6 Acknowledgements
  • 1.7 References
  • Chapter 2. Fast generic HPLC methods
  • 2.1 Introduction.
  • 2.2 Theory
  • 2.3 Strategy for production of fast gradients
  • 2.4 Fast gradients in practice
  • 2.5 References
  • Chapter 3. Application of standard methods in capillary electrophoresis for drug analysis
  • 3.1 Introduction to capillary electrophoresis
  • 3.2 Analysis of pharmaceuticals by CE
  • 3.3 Low-pH buffer for analysis of basic drugs
  • 3.4 High-pH buffer for analysis of acidic drugs
  • 3.5 Micellar electrokinetic chromatography (MEKC) for neutral and/or charged drugs
  • 3.6 Microemulsion electrokinetic chromatography (MEEKC) for neutral and/or charged drugs.
  • 3.7 Indirect UV detection method for analysis of inorganic anions
  • 3.8 Indirect UV detection method for analysis of simple organic acids
  • 3.9 Indirect UV detection method for analysis of metal ions
  • 3.10 Non-aqueous CE for analysis of acidic and basic drugs
  • 3.11 Benefits of adopting standard CE methods
  • 3.12 References
  • Chapter 4. Capillary electrochromatography (CEC)
  • 4.1 Introduction
  • 4.2 Basic principles of capillary electrochromatography
  • 4.3 Mobile phase composition
  • 4.4 Stationary phases used in CEC
  • 4.5 Operational characteristics of CEC.
  • 4.6 Gradient and pressure-assisted (pseudo) CEC
  • 4.7 Conclusions
  • 4.8 Glossary of symbols
  • 4.9 References
  • Chapter 5. Coupled chromatography-mass spectrometry techniques for the analysis of combinatorial libraries
  • 5.1 Introduction
  • 5.2 LC/MS analysis of high-throughput parallel synthesis libraries
  • 5.3 Example for monitoring the rehearsal phase of the synthesis of a solid-phase library
  • 5.4 LC/UV/MS as a pre-screen for autoprep-solution phase
  • 5.5 Assisted automated LC/MS analysis
  • 5.6 The analysis of split-pool combinatorial libraries
  • 5.7 Conclusions and future.
  • 5.8 References
  • Chapter 6. Optimization strategies for HPLC and CZE
  • 6.1 Introduction
  • 6.2 Responses and response functions
  • 6.3 Univariate optimization strategies
  • 6.4 Factorial methods
  • 6.5 Mixture designs
  • 6.6 Robustness/ruggedness
  • 6.7 The simplex sequential approach
  • 6.8 Automating the whole process: expert systems and knowledge based systems
  • 6.9 References
  • Chapter 7. Strategies for the development of process chromatography as a unit operation for the pharmaceutical industry
  • 7.1 Introduction
  • 7.2 The process development cycle.

Ejemplares similares