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Adenosine receptors and Parkinson's disease /
This book is the first definitive overview on adenosine receptor antagonists and their application to the treatment of Parkinson's Disease. The effect of these novel non-dopamine drugs on vitro and in vivo systems clearly shows their potential for the treatment of this debilitating disease. Thi...
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | , , |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
San Diego, CA :
Academic Press,
�2000.
|
| Colección: | Pure and applied mathematics (Academic Press) ;
60. |
| Temas: | |
| Acceso en línea: | Texto completo |
MARC
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| 245 | 0 | 0 | |a Adenosine receptors and Parkinson's disease / |c edited by Hiroshi Kase, Peter J. Richardson, Peter Jenner. |
| 260 | |a San Diego, CA : |b Academic Press, |c �2000. | ||
| 300 | |a 1 online resource (xviii, 275 pages [1] color plate) : |b illustrations | ||
| 336 | |a text |b txt |2 rdacontent | ||
| 337 | |a computer |b c |2 rdamedia | ||
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| 490 | 1 | |a Pure and applied mathematics series ; |v v. 90 | |
| 520 | |a This book is the first definitive overview on adenosine receptor antagonists and their application to the treatment of Parkinson's Disease. The effect of these novel non-dopamine drugs on vitro and in vivo systems clearly shows their potential for the treatment of this debilitating disease. This book covers how the Parkinson's disease antagonist drug, A2A, has been researched, developed, and tested. It is an essential book for researchers interested in the basal ganglia, purine biology, and Parkinson's Disease. Key Features * Discusses the discovery and development of a novel non-dopaminomimetic agent for Parkinson's disease * Provides the first definitive overview of adenosine antagonists and their role in the treatment of Parkinson's disease * Presents a new mechanism of action of adenosine A2A receptor antagonists in motor function Proposes a hypothesis of adenosine A2A receptor function in the striatum * Comprehensive overview of adenosine, its receptor subtypes, their antagonists/agonists from biochemistry, molecular biology, medicinal chemistry, physiology, pharmacology, and neurochemistry viewpoints. | ||
| 505 | 0 | 0 | |t Introductory Remarks: Adenosine A2A Receptor Antagonists: A Novel Approach to the Treatment of Parkinson's Disease. / |r H. Kase -- |t Localisation of Adenosine Receptors in Brain and Periphery. / |r S.J. Augood, P.C. Emsom, and D.G. Standaert -- |t Medicinal Chemistry of Adenosine Receptors in Brain and Periphery. / |r J. Shimada and F. Suzuki -- |t Overview of the Physiology and Pharmacology of Adenosine in the Peripheral System. / |r A. Karasawa -- |t Biochemical Characterization of Adenosine Agonists and Antagonists. / |r H. Nonaka and M. Ichimura -- |t Physiology of Adenosine Receptors in the Striatum: Regulation of Striatal Projection Neurons. / |r A. Mori and T. Shindou -- |t The Regulation of Neurotransmitter Release in Basal Ganglia by Adenosine Receptor Agonists and Antagonists in Vitro and in Vivo. / |r P. Richardson and M. Kurokawa -- |t Control of Gene Expression in the Basal Ganglia Induced by Adenosine Receptors. / |r A. Dixon and P. Richardson -- |t Knockout Mice in the Study of Dopaminergic Diseases. / |r S. Aoyama, J.-H. Baik, H. Kase, and E. Borrelli -- |t Effects of Adenosine Receptors Experimental Models of Cognition and Motor Behaviour. / |r S. Shiozaki, S. Ichikawa, J. Nakamura, and Y. Kuwana -- |t Actions of Adenosine Antagonists in a Primate Model of Parkinson's Disease. / |r T. Kanda and P. Jenner -- |t Selective Adenosine A2A Receptor Antagonism as an Alternative Therapy for Parkinson's Disease: A Study in Nonhuman Primates. / |r A. Tahar, R. Grondin, L. Gregoire, A. Mori, H. Kase, and P.J. Bedard -- |t Neurobiology of Adenosine Receptors: Adenosine and its Metabolites in Movement Disorders. / |r M. Nomoto. |
| 504 | |a Includes bibliographical references and index. | ||
| 588 | 0 | |a Print version record. | |
| 506 | |3 Use copy |f Restrictions unspecified |2 star |5 MiAaHDL | ||
| 533 | |a Electronic reproduction. |b [Place of publication not identified] : |c HathiTrust Digital Library, |d 2010. |5 MiAaHDL | ||
| 538 | |a Master and use copy. Digital master created according to Benchmark for Faithful Digital Reproductions of Monographs and Serials, Version 1. Digital Library Federation, December 2002. |u http://purl.oclc.org/DLF/benchrepro0212 |5 MiAaHDL | ||
| 583 | 1 | |a digitized |c 2010 |h HathiTrust Digital Library |l committed to preserve |2 pda |5 MiAaHDL | |
| 546 | |a English. | ||
| 650 | 0 | |a Parkinson's disease. | |
| 650 | 0 | |a Adenosine |x Receptors. | |
| 650 | 0 | |a Adenosine |x Antagonists |x Therapeutic use. | |
| 650 | 1 | 2 | |a Parkinson Disease |x drug therapy |0 (DNLM)D010300Q000188 |
| 650 | 2 | 2 | |a Purinergic P1 Receptor Antagonists |0 (DNLM)D058915 |
| 650 | 6 | |a Maladie de Parkinson. |0 (CaQQLa)201-0016037 | |
| 650 | 6 | |a Ad�enosine |0 (CaQQLa)201-0007623 |x R�ecepteurs. |0 (CaQQLa)201-0375415 | |
| 650 | 6 | |a Ad�enosine |0 (CaQQLa)201-0007623 |x Antagonistes |0 (CaQQLa)201-0374866 |x Emploi en th�erapeutique. |0 (CaQQLa)201-0373975 | |
| 650 | 7 | |a HEALTH & FITNESS |x Diseases |x Alzheimer's & Dementia. |2 bisacsh | |
| 650 | 7 | |a MEDICAL |x Neurology. |2 bisacsh | |
| 650 | 7 | |a Adenosine |x Receptors. |2 fast |0 (OCoLC)fst00796565 | |
| 650 | 7 | |a Parkinson's disease. |2 fast |0 (OCoLC)fst01053693 | |
| 655 | 4 | |a Electronic books. | |
| 700 | 1 | |a Kase, Hiroshi. | |
| 700 | 1 | |a Richardson, Peter J. | |
| 700 | 1 | |a Jenner, Peter, |d 1946- | |
| 776 | 0 | 8 | |i Print version: |t Adenosine receptors and Parkinson's disease. |d San Diego, CA : Academic Press, �2000 |z 0124004059 |z 9780124004054 |w (DLC) 99062783 |w (OCoLC)42214737 |
| 830 | 0 | |a Pure and applied mathematics (Academic Press) ; |v 60. | |
| 856 | 4 | 0 | |u https://sciencedirect.uam.elogim.com/science/book/9780124004054 |z Texto completo |