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Foundations of comparative genomics /

This book provides an overview of computational analysis of genes and genomes, and of some most notable findings that come out of this work. Foundations of Comparative Genomics presents a historical perspective, beginning with early analysis of individual gene sequences, to present day comparison of...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Autor principal: Mushegian, Arcady R.
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Amsterdam ; Boston : Academic Press, �2007.
Temas:
Acceso en línea:Texto completo

MARC

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245 1 0 |a Foundations of comparative genomics /  |c Arcady R. Mushegian. 
260 |a Amsterdam ;  |a Boston :  |b Academic Press,  |c �2007. 
300 |a 1 online resource (ix, 265 pages) :  |b illustrations 
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520 |a This book provides an overview of computational analysis of genes and genomes, and of some most notable findings that come out of this work. Foundations of Comparative Genomics presents a historical perspective, beginning with early analysis of individual gene sequences, to present day comparison of gene repertoires encoded by completely sequenced genomes. The author discusses the underlying scientific principles of comparative genomics, argues that completion of many genome sequences started a new era in biology, and provides a personal view on several state-of-the-art issues, such as systems biology and whole-genome phylogenetic reconstructions. This book is an essential reference for researchers and students in computational biology, evolutionary biology, and genetics. * Presents an historic overview of genome biology and its achievements * Includes topics not covered in other books such as minimal and ancestral genomes * Discusses the evolutionary resilience of protein-coding genes and frequent functional convergence at the molecular level * Critically reviews horizontal gene transfer and other contentious issues * Covers comparative virology as a somewhat overlooked foundation of modern genome science. 
504 |a Includes bibliographical references (pages 238-257) and index. 
505 0 |a The beginning of computational genomics -- Finding sequence similarities -- Homology: can we get it right? -- Getting ready for the era of comparative genomics: the importance of viruses -- The first fact of comparative genomics: protein sequences are remarkably resilient in evolution -- The second fact of comparative genomics: functional convergence at the molecular level -- Prediction of function and reconstruction of metabolism from genomic data: homology-based approaches -- Prediction of function and reconstruction of metabolism: post-homology approaches -- Structural genomics: what does it tell us about life? -- How many protein families are there? -- Phylogenetic inference and the era of complete genomes -- Two stories about evolution -- Minimal and ancestral genomes -- Comparative genomics and systems biology. 
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546 |a English. 
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650 0 |a Gene mapping. 
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650 2 2 |a Sequence Analysis  |x methods  |0 (DNLM)D017421Q000379 
650 2 |a Genomics  |0 (DNLM)D023281 
650 2 |a Chromosome Mapping  |0 (DNLM)D002874 
650 2 |a Physiology, Comparative  |0 (DNLM)D010828 
650 6 |a G�enomique.  |0 (CaQQLa)201-0363181 
650 6 |a Cartes chromosomiques.  |0 (CaQQLa)201-0060339 
650 6 |a Physiologie compar�ee.  |0 (CaQQLa)201-0040075 
650 6 |a G�en�etique  |x Technique.  |0 (CaQQLa)201-0068339 
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650 7 |a Genomics.  |2 fast  |0 (OCoLC)fst00940228 
650 7 |a Physiology, Comparative.  |2 fast  |0 (OCoLC)fst01063206 
776 0 8 |i Print version:  |a Mushegian, Arcady R.  |t Foundations of comparative genomics.  |d Amsterdam ; Boston : Academic Press, �2007  |z 9780120887941  |z 0120887940  |w (DLC) 2007003418  |w (OCoLC)81252684 
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