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Models of seizures and epilepsy /
An understanding of mechanisms underlying seizure disorders depends critically on the insights provided by model systems. In particular with the development of cellular, molecular, and genetic investigative tools, there has been an explosion of basic epilepsy research. Models of Seizures and Epileps...
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | , , |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Amsterdam ; Boston :
Elsevier Academic,
�2006.
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| Temas: | |
| Acceso en línea: | Texto completo |
MARC
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| 245 | 0 | 0 | |a Models of seizures and epilepsy / |c editors, Asla Pitk�anen, Philip A. Schwartzkroin, Solomon L. Mosh�e. |
| 260 | |a Amsterdam ; |a Boston : |b Elsevier Academic, |c �2006. | ||
| 300 | |a 1 online resource (xvii, 687) : |b illustrations (some color) | ||
| 336 | |a text |b txt |2 rdacontent | ||
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| 520 | |a An understanding of mechanisms underlying seizure disorders depends critically on the insights provided by model systems. In particular with the development of cellular, molecular, and genetic investigative tools, there has been an explosion of basic epilepsy research. Models of Seizures and Epilepsy brings together, for the first time in 30 years, an overview of the most widely-used models of seizures and epilepsy. Chapters cover a broad range of experimental approaches (from in vitro to whole animal preparations), a variety of epileptiform phenomenology (including burst discharges and seizures), and suggestions for model characterization and validation, such as electrographic, morphologic, pharmacologic, and behavioral features. Experts in the field provide not only technical reviews of these models but also conceptual critiques - commenting on the strengths and limitations of these models, their relationship to clinical phenomenology, and their value in developing a better understanding and treatments. Models of Seizures and Epilepsy is a valuable, practical reference for investigators who are searching for the most appropriate laboratory models for addressing key questions in the field. It also provides an important background for physicians, fellows, and students, offering insight into the potential for advances in epilepsy research. The first comprehensive description of animal models of epilepsy since the early 1970's. Comprehensive analysis of "What the models model" to guide the selection of each model, and what specific questions it will answer. Elegant examples of the use of novel technologies that can be applied in experimental epilepsy research. World expert opinions on the clinical relevance of each model | ||
| 504 | |a Includes bibliographical references and index. | ||
| 505 | 0 | |a What Should Be Modeled? -- Single Nerve Cells Acutely Dissociated from Animal and Human Brains for Studies of Epilepsy -- Cell Culture Models for Studying Epilepsy -- An Overview of In Vitro Seizure Models in Acute and Organotypic Slices -- The Use of Brain Slice Cultures for the Study of Epilepsy -- Hippocampal Slices: Designing and Interpreting Studies in Epilepsy Research -- Thalamic, Thalamocortical, and Corticocortical Models of Epilepsy with an Emphasis on Absence Seizures -- Studying Epilepsy in the Human Brain In Vitro -- In Vitro Isolated Guinea Pig Brain -- Pharmacologic Models of Generalized Absence Seizures in Rodents -- Models of Chemically-Induced Acute Seizures -- Electrical Stimulation-Induced Models of Seizures -- Alcohol Withdrawal Seizures -- Alumina Gel Injection Models of Epilepsy in Monkeys -- Modeling Epilepsy and Seizures in Developing Zebrafish Larvae -- Transgenic and Gene Replacement Models of Epilepsy: Targeting Ion Channel and Neurotransmission Pathways in Mice -- Spontaneous Epileptic Mutations in the Mouse -- Genetic Models of Absence Epilepsy in the Rat -- Models with Spontaneous Seizures and Developmental Disruption of Genetic Etiology -- Mammalian Models of Genetic Epilepsy Characterized by Sensory-Evoked Seizures and Generalized Seizure Susceptibil -- Inherited Epilepsy in Mongolian Gerbils -- The Cortical Freeze Lesion Model -- MAM and Other "Lesion" Models of Developmental Epilepsy -- In Utero Irradiation as a Model of Cortical Dysplasia -- Modeling Hypoxia-Induced Seizures and Hypoxic Encephalopathy in the Neonatal Period -- Complex Febrile Seizures-An Experimental Model in Immature Rodents -- Repetitive Seizures in the Immature Brain* -- The Kindling Phenomenon -- Kindling Kittens and Cats -- Electrical Kindling in Developing Rats -- Chemical Kindling -- Kindling, Spontaneous Seizures, and the Consequences of Epilepsy: More Than a Model -- Tetanus Toxin Model of Focal Epilepsy -- Kainate-Induced Status Epilepticus: A Chronic Model of Acquired Epilepsy -- The Pilocarpine Model of Seizures -- Status Epilepticus: Electrical Stimulation Models -- Posttraumatic Epilepsy Induced by Lateral Fluid-Percussion Brain Injury in Rats -- Chronic Partial Cortical Isolation -- Head Trauma: Hemorrhage-Iron Deposition -- Stroke -- Models Available for Infection-Induced Seizures -- Brain Tumor and Epilepsy: A New Neurophysiologic and Neuropathologic Ex Vivo In Vitro Model -- An Animal Model of Rasmussen's Encephalitis -- Therapeutic Assays for the Identification and Characterization of Antiepileptic and Antiepileptogenic Drugs -- Animal Models of Drug-Refracgtory Epilepsy -- Monitoring for Seizures in Rodents -- Imaging Approahes in Small Animal Models -- Behavioral Characterization of Seizures in Rats -- Behavioral andn Cognitive Testing Procedures in Animal Models of Epilepsy -- Morphologic Approaches to the Characterization of Epilepsy Models -- Animal Model Development Based on the Human Epilepsies: Which Causes and Syndromes Should Be Modeled? -- What Good Are Animal Models? | |
| 588 | 0 | |a Print version record. | |
| 650 | 0 | |a Epilepsy. | |
| 650 | 0 | |a Spasms. | |
| 650 | 0 | |a Epilepsy |x Animal models. | |
| 650 | 2 | |a Epilepsy |0 (DNLM)D004827 | |
| 650 | 2 | |a Spasm |0 (DNLM)D013035 | |
| 650 | 6 | |a Spasmes. |0 (CaQQLa)201-0025795 | |
| 650 | 6 | |a �Epilepsie. |0 (CaQQLa)201-0050894 | |
| 650 | 7 | |a PSYCHOLOGY |x Neuropsychology. |2 bisacsh | |
| 650 | 7 | |a Epilepsy |2 fast |0 (OCoLC)fst00914183 | |
| 650 | 7 | |a Epilepsy |x Animal models |2 fast |0 (OCoLC)fst00914185 | |
| 650 | 7 | |a Spasms |2 fast |0 (OCoLC)fst01128762 | |
| 700 | 1 | |a Pitk�anen, Asla. | |
| 700 | 1 | |a Schwartzkroin, P. A. |q (Philip A.) | |
| 700 | 1 | |a Mosh�e, Solomon L. | |
| 776 | 0 | 8 | |i Print version: |t Models of seizures and epilepsy. |d Amsterdam ; Boston : Elsevier Academic, �2006 |z 0120885549 |z 9780120885541 |w (OCoLC)62176884 |
| 856 | 4 | 0 | |u https://sciencedirect.uam.elogim.com/science/book/9780120885541 |z Texto completo |