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The comprehensive sourcebook of bacterial protein toxins /
Bacterial toxins play an important role in infectious diseases. Several are amongst the most potent biological agents known to man. Cholera, pertussis, botulinum, clostridium and tetanus toxins are all produced by bacteria. In many cases, it is the toxin produced and not the infectious agent itself...
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | , |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Amsterdam ; Boston :
Elsevier,
�2006.
|
| Edición: | 3rd ed. |
| Temas: | |
| Acceso en línea: | Texto completo |
MARC
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| 245 | 0 | 4 | |a The comprehensive sourcebook of bacterial protein toxins / |c editors, Joseph E. Alouf and Michel R. Popoff. |
| 246 | 3 | 0 | |a Bacterial protein toxins |
| 250 | |a 3rd ed. | ||
| 260 | |a Amsterdam ; |a Boston : |b Elsevier, |c �2006. | ||
| 300 | |a 1 online resource (xxiii, 1047 pages) : |b illustrations | ||
| 336 | |a text |b txt |2 rdacontent | ||
| 337 | |a computer |b c |2 rdamedia | ||
| 338 | |a online resource |b cr |2 rdacarrier | ||
| 520 | |a Bacterial toxins play an important role in infectious diseases. Several are amongst the most potent biological agents known to man. Cholera, pertussis, botulinum, clostridium and tetanus toxins are all produced by bacteria. In many cases, it is the toxin produced and not the infectious agent itself that causes pathology. Botulinum toxin has now of course found clinical application as botox, and anthrax, and other toxins, have potentially devastating effects if misused as an agent of biological terror. This book describes the major achievements and discoveries relevant to bacterial protein toxins since the turn of the new century, illustrated by the discovery of more than fifty novel toxins (many of them identified through genome screening). The establishment of the three-dimensional crystal structure of more than 20 toxins during the same period offers deeper knowledge of structure-activity relationships and provides a framework to understand how toxins recognize receptors, penetrate membranes and interact with and modify intracellular substrates. * Edited by two of the most highly regarded experts in the field from the Institut Pasteur, France * 14 brand new chapters dedicated to coverage of historical and general aspects of toxinology * Includes the major toxins of both basic and clinical interest are described in depth * Details applied aspects of toxins such as therapy, vaccinology, and toolkits in cell biology * Evolutionary and functional aspects of bacterial toxins evaluated and summarized * Toxin applications in cell biology presented * Therapy (cancer therapy, dystonias) discussed * Vaccines (native and genetically engineered vaccines) featured * Toxins discussed as biological weapons, comprising chapters on anthrax, diphtheria, ricin etc. | ||
| 505 | 0 | |a Introduction -- A 116-year story of bacterial protein toxins (1888-2004): From diphtheritic poison to molecular toxinology -- Evolutionary aspects of toxin-producing bacteria -- Mobile genetic elements and pathogenicity islands encoding bacterial toxins -- Regulation systems of toxin expression -- Toxin secretion systems -- Intracellular trafficking of bacterial protein toxins -- Translocation of bacterial protein toxin into the cytosol -- Bacterial toxins and virulence factors targeting the actin cytoskeleton and -- intracellular junctions -- Bacterial toxins and mitochondria -- Toxins activating RHO GTPases and exploiting the cellular ubiquitin/proteasome -- machineries -- Toxin receptors -- Molecular, functional and evolutionary aspects of ADP-ribosylating toxins -- Diphtheria toxin -- Attack of the nervous system by clostridial toxins: Physical findings, cellular and -- molecular actions -- Uptake and transport of clostridial neurotoxins -- Bacillus anthracis toxins -- Large clostridial cytotoxins modifying small GTPases -- Bordetella protein toxins -- Vibrio Cholerae and Escherichia Coli thermolabile enterotoxin -- The Shiga toxins: Properties and action on cells -- Helicobacter pylori vacuolating toxin -- Pasteurella multocida toxin -- Cytolethal distending toxins -- Pseudomonas aeruginosa toxins -- Escherichia coli heat- stable enterotoxin b -- Paradigms and classification of bacterial membrane -damaging toxins -- Membrane damaging and cytotoxic phospholipases -- Bacteroides fragilis toxins -- Structure and mode of action of RTX cytolysins -- Genetics and phylogeny of RTX cytolysins -- The family of two-component cytolysins of Serratia and other -- bacteria -- Alpha-helix and Beta-barrel pore-forming toxins (leucocidins, alpha-, gamma- and -- delta-cytolysins) of Staphylococcus aureus -- Aerolysin and related Aeromonas toxins -- Clostridium septicum pore-forming alpha-toxin -- Clostridium perfringens epsilon toxin -- Repertoire and general features of the family of cholesteroldependent cytolysins -- Comparative three-dimensional structure of cholesterol-dependent cytolysins -- Perfringolysin O and Intermedilysin: mechanisms of pore formation by the -- cholesterol-dependent cytolysins -- Pneumolysin: structure, function and role in disease -- Listeriolysin -- Enterococcus faecalis cytolysin toxin -- Streptolysin S: one of the most potent and elusive of all bacterial toxins -- The group B streptococcal beta-haemolysin/cytolysin -- Haemolysins of Vibrio cholerae and other Vibrio species -- Clostridium perfringens enterotoxin -- Bacillus cereus enterotoxins, bi- and tri-component cytolysins and other -- haemolysins -- Uropathogenic Escherichia coli cytolysins -- Escherichia coli, Vibrio and Yersinia species heat-stable enterotoxins -- What are superantigens? -- Staphylococcal superantigens and the diseases they cause -- Streptococcal superantigenic toxins -- Superantigenic toxin of Yersinia pseudotuberculosis -- Comparative three-dimensional structure of bacterial superantigenic toxins -- Induction and modulation of inflammatory networks by bacterial protein toxins -- Clostridial toxins in the pathogenesis of gas gangrene -- Staphylococcal exfoliative toxins -- Medical applications of botulinum neurotoxins -- Bacterial protein toxins as food poisons -- Engineering of bacterial toxins for research and medicine -- Engineered bacterial toxin vaccines and adjuvants -- Toxins as tools -- Bacterial protein toxins as biological weapons. | |
| 504 | |a Includes bibliographical references and index. | ||
| 588 | 0 | |a Print version record. | |
| 650 | 0 | |a Bacterial toxins. | |
| 650 | 0 | |a Bacterial proteins. | |
| 650 | 1 | 2 | |a Bacterial Toxins |0 (DNLM)D001427 |
| 650 | 2 | 2 | |a Bacterial Proteins |0 (DNLM)D001426 |
| 650 | 6 | |a Toxines bact�eriennes. |0 (CaQQLa)201-0030653 | |
| 650 | 6 | |a Prot�eines bact�eriennes. |0 (CaQQLa)201-0059876 | |
| 650 | 7 | |a MEDICAL |x Toxicology. |2 bisacsh | |
| 650 | 7 | |a Bacterial proteins |2 fast |0 (OCoLC)fst00825235 | |
| 650 | 7 | |a Bacterial toxins |2 fast |0 (OCoLC)fst00825240 | |
| 655 | 0 | |a Electronic books. | |
| 655 | 4 | |a Electronic books. | |
| 700 | 1 | |a Alouf, J. E. |q (Joseph E.) | |
| 700 | 1 | |a Popoff, Michel R. | |
| 776 | 0 | 8 | |i Print version: |t Comprehensive sourcebook of bacterial protein toxins. |b 3rd ed. |d Amsterdam ; Boston : Elsevier, �2006 |z 0120884453 |z 9780120884452 |w (DLC) 2006271885 |w (OCoLC)63177428 |
| 856 | 4 | 0 | |u https://sciencedirect.uam.elogim.com/science/book/9780120884452 |z Texto completo |
| 856 | 4 | 0 | |u https://sciencedirect.uam.elogim.com/science/book/9780120884452 |z Texto completo |