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The comprehensive sourcebook of bacterial protein toxins /
Bacterial toxins play an important role in infectious diseases. Several are amongst the most potent biological agents known to man. Cholera, pertussis, botulinum, clostridium and tetanus toxins are all produced by bacteria. In many cases, it is the toxin produced and not the infectious agent itself...
| Clasificación: | Libro Electrónico |
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| Otros Autores: | , |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Amsterdam ; Boston :
Elsevier,
�2006.
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| Edición: | 3rd ed. |
| Temas: | |
| Acceso en línea: | Texto completo |
| Sumario: | Bacterial toxins play an important role in infectious diseases. Several are amongst the most potent biological agents known to man. Cholera, pertussis, botulinum, clostridium and tetanus toxins are all produced by bacteria. In many cases, it is the toxin produced and not the infectious agent itself that causes pathology. Botulinum toxin has now of course found clinical application as botox, and anthrax, and other toxins, have potentially devastating effects if misused as an agent of biological terror. This book describes the major achievements and discoveries relevant to bacterial protein toxins since the turn of the new century, illustrated by the discovery of more than fifty novel toxins (many of them identified through genome screening). The establishment of the three-dimensional crystal structure of more than 20 toxins during the same period offers deeper knowledge of structure-activity relationships and provides a framework to understand how toxins recognize receptors, penetrate membranes and interact with and modify intracellular substrates. * Edited by two of the most highly regarded experts in the field from the Institut Pasteur, France * 14 brand new chapters dedicated to coverage of historical and general aspects of toxinology * Includes the major toxins of both basic and clinical interest are described in depth * Details applied aspects of toxins such as therapy, vaccinology, and toolkits in cell biology * Evolutionary and functional aspects of bacterial toxins evaluated and summarized * Toxin applications in cell biology presented * Therapy (cancer therapy, dystonias) discussed * Vaccines (native and genetically engineered vaccines) featured * Toxins discussed as biological weapons, comprising chapters on anthrax, diphtheria, ricin etc. |
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| Descripción Física: | 1 online resource (xxiii, 1047 pages) : illustrations |
| Bibliografía: | Includes bibliographical references and index. |
| ISBN: | 9780120884452 0120884453 0080456987 9780080456980 |