Molecular biology of B cells /

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Molecular Biology of B Cells is a comprehensive reference to how B cells are generated, selected, activated and engaged in antibody production. All these developmental and stimulatory processes are described in molecular and genetic terms to give a clear understanding of complex phenotyes. The molec...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Honjo, T. (Tasuku), 1942-, Alt, Frederick W., Neuberger, M. S. (Michael S.)
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Amsterdam ; Boston : Elsevier, 2004.
Temas:
Molecular immunology.
B cells.
Immunoglobulins.
Immunoglobulin genes.
B-Lymphocytes > immunology
B-Lymphocytes
Genes, Immunoglobulin
Genetic Phenomena
Immunologie mol�eculaire.
Lymphocytes B.
Immunoglobulines.
G�enes de l'immunoglobuline.
B-Lymphozyt
Molekularbiologie
Linf�ocitos b.
Imunologia celular.
Imunoglobulinas.
Biologia molecular.
Internet Resources.
Illustrations.
Acceso en línea:Texto completo
Tabla de Contenidos:
  • ORGANIZATION, REARRANGEMENT AND TRANSCRIPTION OF IMMUNOGLOBULIN GENES
  • Human Immunoglobulin heavy chains locus
  • Immunoglobulin heavy chain genes of mouse
  • Immunoglobulin? genes of human and mouse
  • Immunoglobulin lambdav (IGL) genes of human and mouse
  • The Mechanism of V(D) J Recombination
  • Transcription of Immunoglobulin genes
  • B CELLS AND THEIR DEVELOPMENT
  • Early B cell development to a mature, antigen-sensitive cell
  • cellular stages and molecular decisions
  • Allelic exclusion, Isotypic exclusion and the Developmental Regulation of V(D)J Recombination
  • The Development of Human B Lymphocytes
  • Development and function of B cell subsets
  • B CELL DIFFERENTIATION INDUCED BY Ag STIMULATION
  • Structure and function of B cells antigen receptor complexes
  • Regulation of antigen receptor signaling by the co-receptors, CD19 and CD22
  • The dynamic structure of antibody responses
  • Dynamics of B cell migration to and within secondary lymphoid organs
  • Characteristics of mucosal B cells with emphasis on the human secretory immune system
  • The Cellular Basis of B Cell Memory
  • Immunoglobulin assembly and secretion
  • Fc And Complement Receptors
  • Ig GENE ALTERATION IN PERIPHERY
  • Regulation of Class Switch Recombination
  • Molecular Mechanism of Class Switch Recombination
  • Molecular Mechanism of Hypermutation
  • Selection During Antigen-Driven B Cell Immune Responses: The Basis for High Affinity Antibody
  • DISEASES OF B CELLS
  • Chromosomal Translocations in B-cell Leukemias and Lymphomas
  • Classification and Characteristics of Mouse B Cell-Lineage Lymphomas
  • B cells producing pathogenic autoantibodies
  • Immunodeficiencies Caused by B Cell Defects
  • EVOLUTION OF Ig GENES
  • Diverse forms of Immunoglobulin Genes in Lower Vertebrates
  • Immunoglobulin Genes and Generation of Antibody Repertoires in Higher Vertebrates: A Key Role for GALT
  • The zebrafish immune system
  • The Origin of V(D)J Diversification
  • FUNCTION AND APPLICATION OF IMMUNOGLOBULINS
  • Antibody Structure and Recognition of Antigen
  • Monoclonal antibodies from display libraries
  • Humanization of Monoclonal Antibodies
  • Human monoclonal antibodies from translocus mice.

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