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Histopathology of preclinical toxicity studies : interpretation and relevance in drug safety evaluation /
This book describes histopathological assessment of preclinical toxicology studies that are conducted to assess the safety of novel drugs. It discusses the implications of drug-induced changes that may be relevant to the critical early stages of the development of new therapeutic agents, notably pri...
| Clasificación: | Libro Electrónico |
|---|---|
| Autor principal: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Amsterdam ; New York :
Elsevier Science B.V.,
�2000.
|
| Edición: | 2nd ed. |
| Temas: | |
| Acceso en línea: | Texto completo |
MARC
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| 100 | 1 | |a Greaves, P. |q (Peter) | |
| 245 | 1 | 0 | |a Histopathology of preclinical toxicity studies : |b interpretation and relevance in drug safety evaluation / |c Peter Greaves. |
| 250 | |a 2nd ed. | ||
| 260 | |a Amsterdam ; |a New York : |b Elsevier Science B.V., |c �2000. | ||
| 300 | |a 1 online resource (viii, 900 pages) : |b illustrations (some color) | ||
| 336 | |a text |b txt |2 rdacontent | ||
| 337 | |a computer |b c |2 rdamedia | ||
| 338 | |a online resource |b cr |2 rdacarrier | ||
| 520 | |a This book describes histopathological assessment of preclinical toxicology studies that are conducted to assess the safety of novel drugs. It discusses the implications of drug-induced changes that may be relevant to the critical early stages of the development of new therapeutic agents, notably prior to their first administration to humans and during early clinical trials. Covering virtually all aspects of drug-induced pathology in preclinical toxicity studies, the book is termed the 'gold standard' in the illustration of histopathology. This second revised edition continues to fill the gap for pathology literature relating to the development of new medicines and assessment of their safety based on preclinical studies. In addition to the updated references this edition contains many older references, some out of reach of modern computer based search tools. | ||
| 505 | 0 | |a Preface to second edition. -- Chapter I. Integumentary System. -- Skin and subcutaneous tissue. -- Chapter II. Mammary Gland. -- Chapter III. Haemopoietic and Lymphatic Systems. -- Blood/bone marrow. -- Lymphoid system. -- Lymph nodes. -- Spleen. -- Thymus. -- Lymphoreticular neoplasms. -- Chapter IV. Musculoskeletal System. -- Bone. -- Joints. -- Skeletal muscle. -- Chapter V. Respiratory Tract. -- Nose, nasal sinuses, nasopharynx and pharynx. -- Larynx and trachea. -- Bronchi and lungs. -- Chapter VI. Cardiovascular System. -- Heart and pericardium -- Systemic blood vessels -- Pulmonary blood vessels -- Chapter VII. Digestive System 1. -- Forestomach. -- Stomach (glandular). -- Small intestine. -- Large intestine. -- Chapter VIII. Digestive System 2. -- Liver. -- Bile ducts, biliary system . -- Pancreas. -- Chapter IX. Urinary System. -- Kidney. -- Urinary bladder. -- Chapter X. Male Genital Tract. -- Prostate gland. -- Epididymis. -- Testis. -- Chapter XI. Female Genital Tract. -- Vagina. -- Cervix. -- Uterus. -- Ovary. -- Chapter XII. Endocrine System. -- Pituitary gland. -- Adrenal gland. -- Thyroid gland. -- Parathyroid gland. -- Chapter XIII. Nervous System and Special Sense Organs. -- Brain. -- Spinal cord, spinal nerve roots, peripheral nerves. -- Eye. -- Ear. -- Subject index. | |
| 504 | |a Includes bibliographical references and index. | ||
| 588 | 0 | |a Print version record. | |
| 650 | 0 | |a Drugs |x Toxicity testing. | |
| 650 | 0 | |a Laboratory animals |x Histopathology. | |
| 650 | 1 | 2 | |a Drug Evaluation, Preclinical |0 (DNLM)D004353 |
| 650 | 2 | 2 | |a Animals, Laboratory |0 (DNLM)D000830 |
| 650 | 2 | 2 | |a Histology |0 (DNLM)D006653 |
| 650 | 2 | 2 | |a Pathology |0 (DNLM)D010336 |
| 650 | 6 | |a M�edicaments |0 (CaQQLa)201-0002990 |x Toxicit�e. |0 (CaQQLa)201-0381005 | |
| 650 | 6 | |a Animaux de laboratoire |0 (CaQQLa)201-0001371 |x Histopathologie. |0 (CaQQLa)201-0379026 | |
| 650 | 6 | |a Animaux de laboratoire. |0 (CaQQLa)201-0001371 | |
| 650 | 6 | |a Histologie. |0 (CaQQLa)201-0006148 | |
| 650 | 7 | |a Drugs |x Toxicity testing |2 fast |0 (OCoLC)fst00898957 | |
| 655 | 0 | |a Electronic books. | |
| 655 | 4 | |a Electronic books. | |
| 776 | 0 | 8 | |i Print version: |a Greaves, P. (Peter). |t Histopathology of preclinical toxicity studies. |b 2nd ed. |d Amsterdam ; New York : Elsevier Science B.V., �2000 |z 0444505148 |z 9780444505149 |w (DLC) 00066293 |w (OCoLC)45419002 |
| 856 | 4 | 0 | |u https://sciencedirect.uam.elogim.com/science/book/9780444505149 |z Texto completo |
| 856 | 4 | 0 | |u https://sciencedirect.uam.elogim.com/science/book/9780444505149 |z Texto completo |