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Trends in drug research II : proceedings of the 11th Noordwijkerhout-Camerino Symposium, 11-15 May 1997, Noordwijkerhout /
This volume of Pharmacochemistry Library comprises the text of invited lectures presented at the 11th Noordwijkerhout-Camerino Symposium <IT>Trends in Drug Research</IT>, held in Noordwijkerhout, The Netherlands, from 11-15 May 1997. In the programme attention has been given to the gener...
| Clasificación: | Libro Electrónico |
|---|---|
| Autor Corporativo: | |
| Otros Autores: | |
| Formato: | Electrónico Congresos, conferencias eBook |
| Idioma: | Inglés |
| Publicado: |
Amsterdam ; New York :
Elsevier,
1998.
|
| Colección: | Pharmacochemistry library ;
v. 29. |
| Temas: | |
| Acceso en línea: | Texto completo Texto completo Texto completo |
MARC
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| 111 | 2 | |a Noordwijkerhout-Camerino Symposium |n (11th : |d 1997 : |c Noordwijkerhout, Netherlands) | |
| 245 | 1 | 0 | |a Trends in drug research II : |b proceedings of the 11th Noordwijkerhout-Camerino Symposium, 11-15 May 1997, Noordwijkerhout / |c edited by Henk van der Goot. |
| 246 | 3 | |a Trends in drug research 2 | |
| 246 | 3 | |a Trends in drug research two | |
| 260 | |a Amsterdam ; |a New York : |b Elsevier, |c 1998. | ||
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| 490 | 1 | |a Pharmacochemistry library ; |v v. 29 | |
| 520 | |a This volume of Pharmacochemistry Library comprises the text of invited lectures presented at the 11th Noordwijkerhout-Camerino Symposium <IT>Trends in Drug Research</IT>, held in Noordwijkerhout, The Netherlands, from 11-15 May 1997. In the programme attention has been given to the generation of new biological target systems and the generation of new lead molecules, with presentations on e.g. combinatorial chemistry, compound libraries, database search, high throughput screening and molecular biology. Other topics discussed were the perspectives for new medicines for the gastro-intestinal tract, the major developments in the search for effective anti-HIV drugs and new aspects in synthetic approaches. In a special session three topics which currently draw much attention were discussed: How to deal with the major problem of resistance against antimirobial agents? Can the apoptosis mechanism be used as a drug target? Is the newly observed phenomenon of inverse agonism a general principle and has it consequences for drug development (and use?). | ||
| 505 | 0 | |a Selected papers: Preface. Insights into the structure and function of genetic disease genes from genome research and clues for drug therapy (P.L. Pearson). New Developments in synthetic medicinal chemistry (F. Gaultieri). New biocatalytic approaches for the synthesis of chiral drugs, intermediates, and substrates (K. Laumen <IT>et al</IT>.). Ligands for the 5-HT <INF>2C</INF> receptor as potential antidepressents and anxiolytics (D. Leysen, J. Kelder). 5-HT <INF>1A</INF>-affinity, activity and selectivity <IT>versus</IT> D<INF>2</INF>-receptors of flesinoxan and analogous (W. Kuipers). Pharmacokinetics and metabolism in drug development: current and future strategies (D.D. Breimer). Novel approaches towards anti-HIV chemotherapy (E. De Clercq). HBY 097 -- a second-generation nonnucleoside inhibitor of the HIV-1 reverse transcriptase (J-P. Kleim). The HIV tat-TAR interaction, a novel target for drug discovery (J. Karn <IT>et al</IT>.). Diverse approaches to combinatorial library design (E.J. Martin <IT>et al</IT>.). Heterocyclic mixture- based combinatorial libraries: synthesis and analysis of composition (J.S. Kiely, Y. Pei). Chemistry and SAR of prokinetic motilides: non peptidic motilin receptor agonists (P.A. Lartey). Modulators of 5-HT functions in the treatment of gastrointestinal disorders (F.D. King <IT>et al</IT>.). The impact of robotics and novel assay technologies on lead discovery processes (J.G. Houston). Hot topics (P. Angeli). Inverse agonism at G protein-coupled receptors. Studies with wild type and mutated adrenergic and opioid receptors (G. Milligan). Antibiotic resistance -- a view from the pharmaceutical industry (R. Bax). | |
| 504 | |a Includes bibliographical references and index. | ||
| 588 | 0 | |a Print version record. | |
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