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Advances in DNA sequence specific agents : a research annual. Volume 3 /
In this volume the entire focus is devoted to the macromolecule target specificity of DNA interactive developmental therapeutic agents of current interest. A brief introduction to DNA interactive anticancer agents is included for readers who may benefit from an overview surrounding the developments...
| Clasificación: | Libro Electrónico |
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| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Greenwich (Connecticut) ; London :
Jai Press,
1998.
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| Temas: | |
| Acceso en línea: | Texto completo Texto completo |
Tabla de Contenidos:
- Preface. Introduction to DNA Sequence-specific agents . Sequence-specific poisons of type II DNA topoisomerases. Topoisomerase I-targeting drugs: new developments in cancer pharmacology. DNA sequence recognition altered BIS-benzimidazole minor-groove binders. Sequence-specific recognition and modification of double-helical DNA by minor-groove binding conjugates structurally related to netropsin and distamycin. New developments in the use of nitrogen mustard alkylating agents as anticancer drugs. DNA binding of nonclassical platinum antitumor complexes. Kedarcidin and maduropeptin: two novel antitumor chromoproteins with selective protease activity and DNA cleaving properties. Antisense- and antigene-based drug design strategies in oncology. Sequence-specific recognition of double-stranded DNA by peptide nucleic acids.