Cargando…

Advances in DNA sequence specific agents : a research annual. Volume 3 /

In this volume the entire focus is devoted to the macromolecule target specificity of DNA interactive developmental therapeutic agents of current interest. A brief introduction to DNA interactive anticancer agents is included for readers who may benefit from an overview surrounding the developments...

Descripción completa

Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Hurley, Laurence H. (�ed.)
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Greenwich (Connecticut) ; London : Jai Press, 1998.
Temas:
Acceso en línea:Texto completo
Texto completo

MARC

LEADER 00000cam a2200000 a 4500
001 SCIDIR_ocn162130678
003 OCoLC
005 20231117014838.0
006 m o d
007 cr cn|||||||||
008 070802s1998 ctua ob 000 0 eng d
040 |a OPELS  |b eng  |e pn  |c OPELS  |d OPELS  |d OCLCQ  |d OCLCE  |d OCLCQ  |d GBVCP  |d OCLCF  |d UIU  |d YDXCP  |d OCLCQ  |d DEBSZ  |d LEAUB  |d S2H  |d OCLCO  |d OCLCQ  |d OCLCO 
019 |a 760073434 
020 |z 9780762302031 
020 |z 0762302038 
035 |a (OCoLC)162130678  |z (OCoLC)760073434 
050 4 |a QP625.N89  |b A38 1998 
060 4 |a QH 431 
082 0 4 |a 572.8/633  |2 22 
245 0 0 |a Advances in DNA sequence specific agents :  |b a research annual.  |n Volume 3 /  |c editor Laurence H. Hurley. 
260 |a Greenwich (Connecticut) ;  |a London :  |b Jai Press,  |c 1998. 
300 |a 1 online resource (x, 283 pages) :  |b illustrations 
336 |a text  |b txt  |2 rdacontent 
337 |a computer  |b c  |2 rdamedia 
338 |a online resource  |b cr  |2 rdacarrier 
520 |a In this volume the entire focus is devoted to the macromolecule target specificity of DNA interactive developmental therapeutic agents of current interest. A brief introduction to DNA interactive anticancer agents is included for readers who may benefit from an overview surrounding the developments that have contributed to our general understanding of this field. The following nine chapters have been carefully chosen so that they describe topics which are at the forefront of development in DNA-targeted cancer chemotherapy. Issues that have been addressed include the mechanisms of selective DNA topoisomerase I and II poisoning by antitumor agents (Chapters 1 and 2), sequence-specific recognition of DNA by groove-binding drugs and drug-conjugates (Chapters 3 and 4), recent developments in nitrogen mustard alkylating agents and their potential use for antibody-directed enzyme-prodrug therapy (Chapter 5), nonclassical platinum anticancer complexes, including dinuclear and trans-platinum derivatives (Chapter 6), DNA cleaving antitumor chromoproteins containing reactive enediyne moieties, which exhibit interesting free-radical chemistry along with selective targeting (Chapter 7), the potential of new sequence-specific antisense and antigene therapy in oncology (Chapter 8), and finally the conceivable chemotherapeutic use of mimetics of the DNA structure, obtained by substitution of the sugar-phosphate natural chain with a peptide backbone, the so-called peptide nucleic acids (Chapter 9). Important approaches being currently investigated for selective cancer treatment, such as gene therapy and immunochemotherapy, are not discussed in this volume since they fall beyond its scope. 
505 0 |a Preface. Introduction to DNA Sequence-specific agents . Sequence-specific poisons of type II DNA topoisomerases. Topoisomerase I-targeting drugs: new developments in cancer pharmacology. DNA sequence recognition altered BIS-benzimidazole minor-groove binders. Sequence-specific recognition and modification of double-helical DNA by minor-groove binding conjugates structurally related to netropsin and distamycin. New developments in the use of nitrogen mustard alkylating agents as anticancer drugs. DNA binding of nonclassical platinum antitumor complexes. Kedarcidin and maduropeptin: two novel antitumor chromoproteins with selective protease activity and DNA cleaving properties. Antisense- and antigene-based drug design strategies in oncology. Sequence-specific recognition of double-stranded DNA by peptide nucleic acids. 
504 |a Bibliogr. Index. 
588 0 |a Print version record. 
650 0 |a Nucleotide sequence. 
650 0 |a Molecular biology. 
650 2 |a Molecular Biology  |0 (DNLM)D008967 
650 6 |a Biologie mol�eculaire.  |0 (CaQQLa)201-0064024 
650 7 |a molecular biology.  |2 aat  |0 (CStmoGRI)aat300054470 
650 7 |a Molecular biology  |2 fast  |0 (OCoLC)fst01024734 
650 7 |a Nucleotide sequence  |2 fast  |0 (OCoLC)fst01041106 
650 7 |a ADN.  |2 fmesh 
650 7 |a G�en�etique biochimique.  |2 fmesh 
650 7 |a G�enie g�en�etique.  |2 fmesh 
700 1 |a Hurley, Laurence H.,  |e �ed. 
776 0 8 |i Print version:  |t Advances in DNA sequence specific agents.  |d Greenwich (Connecticut) ; London : Jai Press, 1998  |z 0762302038  |z 9780762302031  |w (OCoLC)40941431 
856 4 0 |u https://sciencedirect.uam.elogim.com/science/book/9780762302031  |z Texto completo 
856 4 0 |u https://sciencedirect.uam.elogim.com/science/bookseries/1067568X/3  |z Texto completo