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Target validation in drug discovery /
This work presents a comprehensive contemporary framework for approaching target validation in drug discovery. It begins with a detailed description of new enabling technologies, including aptamers, RNA interference, functional genomics, and proteomics. The next section looks at biologic drug develo...
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | , |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Amsterdam ; Boston :
Academic Press,
�2007.
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| Temas: | |
| Acceso en línea: | Texto completo |
MARC
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| 245 | 0 | 0 | |a Target validation in drug discovery / |c editors, Brian W. Metcalf and Susan Dillon. |
| 260 | |a Amsterdam ; |a Boston : |b Academic Press, |c �2007. | ||
| 300 | |a 1 online resource (xii, 279 pages) : |b illustrations | ||
| 336 | |a text |b txt |2 rdacontent | ||
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| 520 | |a This work presents a comprehensive contemporary framework for approaching target validation in drug discovery. It begins with a detailed description of new enabling technologies, including aptamers, RNA interference, functional genomics, and proteomics. The next section looks at biologic drug development with in-depth discussion of lessons learned from such well-known cases as Erbitux, Herceptin, and Avastin. Additional targets known as "second generation" drugs, which can be identified when disease pathways are validated by biologics, present new possible small molecule therapeutics and serve as the focus of the final section of the book | ||
| 505 | 0 | |a Section Contents -- I. Pharmaceutical Biotechnology for Target Validation -- II. Target Validation for Biopharmaceutical Drug Discovery -- III. Validating Targets of Small Molecule Approaches. | |
| 504 | |a Includes bibliographical references and index. | ||
| 588 | 0 | |a Print version record. | |
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| 650 | 0 | |a High throughput screening (Drug development) | |
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| 700 | 1 | |a Metcalf, Brian W. | |
| 700 | 1 | |a Dillon, Susan, |d 1952- | |
| 776 | 0 | 8 | |i Print version: |t Target validation in drug discovery. |d Amsterdam ; Boston : Academic Press, �2007 |z 0123693934 |z 9780123693938 |w (DLC) 2006049868 |w (OCoLC)70823305 |
| 856 | 4 | 0 | |u https://sciencedirect.uam.elogim.com/science/book/9780123693938 |z Texto completo |