Chemistry and biology of heparin and heparan sulfate /

The chemistry, biochemistry and pharmacology of heparin and heparan sulfate have been and continue to be a major scientific undertaking - heparin and its derivative remain important drugs in clinical practice. Chemistry and Biology of Heparin and Heparan Sulfate provides readers with an insight into...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Garg, Hari G., 1931-, Linhardt, Robert J., Hales, Charles A., 1941-
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Amsterdam ; Boston ; London : Elsevier, 2005.
Edición:1st ed.
Temas:
Heparin.
Heparin > physiology
Heparin > therapeutic use
Heparin
Heparitin Sulfate > physiology
Heparitin Sulfate > therapeutic use
H�eparine.
MEDICAL > Physiology.
SCIENCE > Life Sciences > Human Anatomy & Physiology.
heparine
heparin
chemische eigenschappen
chemical properties
moleculaire structuur
molecular conformation
proteoglycanen
proteoglycans
biosynthese
biosynthesis
biodegradatie
biodegradation
biologische eigenschappen
biological properties
Biochemistry
Biochemie
Internet Resources.
Acceso en línea:Texto completo
Tabla de Contenidos:
  • 1. Structure and Active Domains of Heparin.
  • 2. Structure and Function of Cell Associated and Pericellular Heparan Sulfate.
  • 3. Methods for Structural Analysis of Heparin and Heparan Sulfate.
  • 4. Synthetic Approach to Define Structure-Activity Relationship of Heparin and Heparan Sulfate.
  • 5. Biochemical and Pharmacological Rationale for Synthetic Heparin Polysaccharides.
  • 6. Seperation and Sequencing of Heparin and Heparan Sulfate Saccharides.
  • 7. Biosynthesis of Heparin and Heparan Sulfate.
  • 8. Remodeling of Heparan Sulfate by Extracellular Endosulfatases.
  • 9. Heparan Sulfate Degradation by Heparanases.
  • 10. Lysosomal Degradation of Heparin and Heparan Sulfate.
  • 11. Heparin Regulation of the Complement System.
  • 12. Surface-Based Studies of Heparin/Heparan Sulfate-Protein Interactions: Consideartions for Surface Immobilisation of HS/Heparin Saccharides and Monitoring their Interactions with Binding Proteins.
  • 13. Heparin Activation of Serpins.
  • 14. Role of Heparin in Fibroblast Signalling.
  • 15. Role of Anticoagulant Heparan Sulfate in Mammalian Reproduction.
  • 16. Glycol-Splitting as a Device for Modulating Inhibition of Growth Factors and Heparanase by Heparin and Heparin Derivatives.
  • 17. Antithrombin Activation and Designing Novel Heparin Mimics.
  • 18. Influence of Heparin Chemical Modifications on Its Antiproliferative Properties.
  • 19. Mechanisms of Cell Growth Regulation by Heparin and Heparan Sulfate.
  • 20. Heparin and Low Molecular Weight Heparin in Thrombosis and Inflammation: Emerging Link.
  • 21. Basic and Clinical Differences of Heparin and Low Molecular Weight Heparin.
  • 22. Perlecan: An Extracellular Matrix Heparan Sulfate Proteoglycan that Regulates Key Events in Vascular Development and Disease.
  • 23. Heparin and Low Molecular Weight Heparins in Clinical Cardiology.
  • 24. Heparin-Induced Thrombocytopenia.
  • 25. Role of Heparan Sulfate in Cancer.
  • 26. Use of Heparin Preparations in Older Patients.
  • 27. Advances in Low Molecular Weight Heparin Use in Pregnancy.

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