Gene therapy of the central nervous system : from bench to bedside /

Few areas of biomedical research provide greater opportunities for radically new therapies for devastating diseases that have evaded treatment so far than gene therapy. This is particularly true for the brain and nervous system, where gene transfer has become a key technology for basic research and...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Kaplitt, Michael G., During, Matthew J.
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Amsterdam ; Boston : Academic Press, 2006.
Temas:
Nervous system > Diseases > Gene therapy.
Gene therapy.
Central Nervous System Diseases > therapy
Genetic Therapy
Syst�eme nerveux > Maladies > Th�erapie g�enique.
Th�erapie g�enique.
HEALTH & FITNESS > Diseases > Nervous System (incl. Brain)
MEDICAL > Neurology.
Gene therapy
Acceso en línea:Texto completo
Tabla de Contenidos:
  • SECTION I. GENE TRANSFER TECHNOLOGY AND REGULATORY ISSUES
  • 1. Design and optimization of expression cassettes including promoter choice and regulatory lements
  • 2. Identification of Novel AAV Serotypes for Use as Vectors
  • 3. HSV amplicon vectors for gene delivery to the nervous system
  • 4. Influence of the immune system on CNS gene transfer
  • 5. Targeted induction of endogenous neural stem and progenitor cells: A new strategy for gene therapy of neurological disease
  • 6. Neurosurgical Targeting, Delivery and Infusion of Gene Therapy Agents in the Brain
  • 7. Gene Transfer for Neurological Disease: Agencies, Policies and Process
  • SECTION II. GENE THERAPY FOR DEGENERATIVE AND FUNCTIONAL DISORDERS
  • 8. Gene therapy for Parkinsons disease
  • 9. Non human primate models for testing gene therapy for neurodegenerative disorders
  • 10. Delivery of Molecular Therapeutics into the CNS and their Distribution within the Brain
  • 11. Gene therapy for CNS diseases using intrabodies
  • 12. Gene therapy for epilepsy
  • SECTION IIII. PSYCHIATRIC AND BEHAVIORAL GENE THERAPY
  • 13. Genetic manipulation of learning and memory
  • 14. Psychiatric applications of viral vectors
  • 15. Use of viral vectors to influencebehavior
  • SECTION IV. GENE THERAPY FOR PAIN AND SPINAL CORD DISEASES
  • 16. Herpes simplex vector mediated gene transfer to the peripheralnervous system for the treatment of polyneuropathy and chronic pain
  • 17. Characterization of pain receptors in the spinal cord using a viral vector for spatial-temportal gene targeting
  • 18. Viral vector mediated gene therapy of pain
  • 19. VEGF, an angiogenic factor with neurotrophic activity, useful for treatment of ALS?
  • 20. Viral Vector Axonal Uptake and Retrograde Transport: Mechanisms and Applications
  • 21. Gene therapy for spinal cord injury
  • V. GENE THERAPY FOR BRAIN TUMORS AND NEUROGENETIC DISEASES
  • 22. Prodrug-Activation Gene Therapy
  • 23. Clinical trials of gene therapy for Canavan Disease
  • 24. Gene therapy for the late infantile form of Batten disease
  • 25. Molecular Imaging of Gene Therapy for Neurogenetic Diseases.

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