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Myelin biology and disorders /

With the completion of the "Human Genome Project" and the cloning and complete molecular description of the known myelin genes, the stage has been set for a detailed understanding of the biology of myelin, the disease processes affecting myelin and the potential for myelin repair and regen...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Autor principal: Lazzarini, Robert A.
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Sand Diego, Calif. : Elsevier Academic Press, �2004.
Temas:
Acceso en línea:Texto completo

MARC

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100 1 |a Lazzarini, Robert A. 
245 1 0 |a Myelin biology and disorders /  |c Robert A. Lazzarini. 
260 |a Sand Diego, Calif. :  |b Elsevier Academic Press,  |c �2004. 
300 |a 1 online resource (2 volumes) :  |b illustrations (some color) 
336 |a text  |b txt  |2 rdacontent 
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520 |a With the completion of the "Human Genome Project" and the cloning and complete molecular description of the known myelin genes, the stage has been set for a detailed understanding of the biology of myelin, the disease processes affecting myelin and the potential for myelin repair and regeneration. Myelin Biology and Disorders brings together in one place, the recent advances in molecular and cellular biology along with visual data from MRI, confocal microscopy and high voltage EM techniques to provide new insights into disease mechanisms. This book represents a unique research reference on myelin biology and will serve as the definitive resource for both the professional clinical and basic scientist. * Critically reviews and evaluates all the important genetic and molecular and cellular biological data on the individual myelin genes/proteins * Details the structural and functional biology of myelin, including a look at the relationship between neuronal damage and myelin damage as seen in multiple sclerosis * Includes forward-looking section on potential therapeutic interventions in myelin diseases 
505 0 |a Section I: Diseases of Myelin -- Leukodystrophies: Overview and Classification -- Multiple Sclerosis: Classification and Overview -- Genetic Susceptibility and Epidemiology -- Cellular Damage and Repair in MS -- MRI Visualization of MS -- Multiple Sclerosis (General Clinical and Trials) -- Adrenoleukodystrophies -- Krabbe's Disease -- Alexander's Disease -- Pelizeaus-Merzbacher Disease -- Guillain Barre Syndrome -- Charcot-Marie-Tooth Disease -- Infectious Demyelinating Diseases -- Ischemic White Matter Damage -- Protein Misfolding as a Disease Determinant -- Section II: Animals Models of Human Disease -- Experimental Allergic Encephalomyelitis -- Experimental Models of Virus Induced Demyelination -- Model's of Krabbe's Disease -- Model's of Alexander's Disease -- Model's of Pelizeaus Merzbacher Disease -- Models of Charcot-Marie-Tooth Disease -- Section III: The Myelin Genes and Products -- Myelin Basic Protein Gene -- Proteolipid Protein Gene -- Myelin Associated Glycoprotein Gene -- Myelin Oligodendrocyte Glycoprotein Gene -- Cyclic Nucleotide Phosophohydrolase Gene -- P0 Protein Gene -- PMP 22 Gene -- The Claudin 11 Gene -- The Neurexin Gene -- The Connexin 32 Gene -- The Integrin Genes -- The Periaxin Gene -- The QK1 Gene -- Section IV: Glial Cell Development -- Invertebrate Glia -- Neural Cell Specification During Development -- Progenitor Cells of the Adult Human White Matter -- Oligodendrocyte Lineage -- Astrocyte Lineage -- Schwann Cell Development -- Olfactory Ensheathing Cells -- Section V: Glial Cell and Myelin Functional Biology -- Structure of the Myelinated Axon -- Cell Biology of Myelin Assembly -- The Transport and Assembly of Myelin Lipids -- Functional Organization of the Nodes of Ranvier -- Electrophysiologic Consequences of Myelination -- Remyelination Through Engraftment -- Remyelination by Endogenous Glia. 
504 |a Includes bibliographical references and index. 
505 0 |a v. 1. Biology -- v. 2. Disorders. 
588 0 |a Print version record. 
650 0 |a Myelin sheath. 
650 0 |a Myelin sheath  |x Pathophysiology. 
650 0 |a Myelin sheath  |x Diseases  |x Animal models. 
650 0 |a Demyelination. 
650 0 |a Myelin proteins. 
650 0 |a Myelin genes. 
650 0 |a Myelin sheath  |x Diseases. 
650 0 |a Diseases  |x Animal models. 
650 1 2 |a Myelin Sheath  |x physiology  |0 (DNLM)D009186Q000502 
650 2 |a Myelin Sheath  |0 (DNLM)D009186 
650 2 |a Myelin Proteins  |0 (DNLM)D009185 
650 2 2 |a Demyelinating Diseases  |0 (DNLM)D003711 
650 2 2 |a Disease Models, Animal  |0 (DNLM)D004195 
650 2 2 |a Myelin Proteins  |x genetics  |0 (DNLM)D009185Q000235 
650 6 |a Gaine de my�eline.  |0 (CaQQLa)201-0130874 
650 6 |a Prot�eines my�eliniques.  |0 (CaQQLa)201-0217104 
650 6 |a G�enes my�eliniques.  |0 (CaQQLa)201-0217063 
650 6 |a Gaine de my�eline  |x Maladies.  |0 (CaQQLa)201-0007360 
650 6 |a Gaine de my�eline  |0 (CaQQLa)201-0130874  |x Physiopathologie.  |0 (CaQQLa)201-0379296 
650 6 |a Gaine de my�eline  |0 (CaQQLa)201-0007360  |x Maladies  |0 (CaQQLa)201-0007360  |x Mod�eles animaux.  |0 (CaQQLa)201-0375873 
650 6 |a D�emy�elinisation.  |0 (CaQQLa)201-0007358 
650 6 |a Maladies  |x Mod�eles animaux.  |0 (CaQQLa)201-0067878 
650 7 |a Myelin sheath  |x Diseases  |2 fast  |0 (OCoLC)fst01031386 
650 7 |a Myelin proteins  |2 fast  |0 (OCoLC)fst01031384 
650 7 |a Myelin genes  |2 fast  |0 (OCoLC)fst01031382 
650 7 |a Diseases  |x Animal models  |2 fast  |0 (OCoLC)fst00895160 
650 7 |a Demyelination  |2 fast  |0 (OCoLC)fst00890241 
650 7 |a Myelin sheath  |2 fast  |0 (OCoLC)fst01031385 
650 7 |a Myelin sheath  |x Pathophysiology  |2 fast  |0 (OCoLC)fst01031387 
650 7 |a Neur�onios.  |2 larpcal 
650 7 |a Fibras nervosas.  |2 larpcal 
650 7 |a Mielina de animal.  |2 larpcal 
776 0 8 |i Print version:  |a Lazzarini, Robert A.  |t Myelin biology and disorders.  |d Sand Diego, Calif. : Elsevier Academic Press, �2004  |z 0124395104  |z 9780124395107  |w (DLC) 2003062808  |w (OCoLC)53076190 
856 4 0 |u https://sciencedirect.uam.elogim.com/science/book/9780124395107  |z Texto completo