The practice of medicinal chemistry /

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Most medicinal chemists working in the pharmaceutical industry are organic synthetic chemists with little or no background in medicinal chemistry. These chemists must acquire a good knowledge of medicinal chemistry during their first years in the pharmaceutical/drug discovery industry. This book aim...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Wermuth, C. G.
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Amsterdam ; Boston : Academic Press, 2003.
Edición:2nd ed.
Temas:
Pharmaceutical chemistry.
Drugs > Design.
Chemical models.
Chemistry, Pharmaceutical
Drug Design
Models, Chemical
Pharmaceutical Preparations > chemistry
Chimie pharmaceutique.
M�edicaments > Conception.
Mod�eles chimiques.
MEDICAL > Drug Guides.
MEDICAL > Pharmacology.
MEDICAL > Pharmacy.
MEDICAL > Nursing > Pharmacology.
Medische chemie.
Drug targeting.
Structuur-activiteit-relatie.
Receptoren.
Farmacokinetica.
Farmacochemie.
Qu�imica farmac�eutica.
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Foreward.
  • Preface.
  • A Brief History Of Drugs
  • From Plant Extracts To DNA Technology
  • Medicinal Chemistry: Definition And Objectives, The Three Main Phases Of Drug Activity, Drug And Diseases Classifications
  • Measurement And Expression Of Drug Effects
  • Drug Targets: Molecular Mechanisms Of Drug Action
  • Strategies In The Search For New Lead Compounds Or Original Working Hypotheses
  • Natural Products As Pharmaceuticals And Sources For Lead Structures
  • Basics Of Combinatorial Chemistry
  • The Contribution Of Molecular Biology To Drug Discovery
  • Electronic Screening: Lead Finding From Database Mining
  • High-Speed Chemistry Libraries: Assessment Of Drug-Likeness
  • Web Alert Using The Internet For Medicinal Chemistry
  • Molecular Variations In Homologous Series: Vinylogues And Benzologues
  • Molecular Variations Based On Isosteric Replacements
  • Ring Transformations
  • Introduction Of Conformational Restriction And/Or Steric Hindrance
  • Identical And Non Identical Twin Drugs
  • Optical Isomerism In Drugs
  • Application Strategies For The Primary Structure-Activity Relationship Exploration
  • Specific Substituent Groups
  • The Role Of Functional Groups In Drug-Receptor Interactions
  • Compound Properties And Drug Quality
  • Quantitative Approaches To Structure-Activity Relationships
  • Structural Aspects Of Drug Action I
  • Pharmacophore Identification And Receptor Mapping
  • Three-Dimentional Quantitative Structure-Property Relationships
  • Protein Crystallography And Drug Discovery
  • Protein Comparative Modelling And Drug Discovery
  • The Transition From Agonist To Antagonist Activity: Symmetry And Other Considerations
  • Design Of Peptidomimetics
  • The Fate Of Xenobiotics In Living Organisms
  • Biotransformation Reactions
  • Chemical Mechanisms Of Toxicity
  • Basic Knowledge For Designing Safer Drugs
  • Designing Prodrugs And Bioprecursors
  • Macromolecular Carriers For Drug Targeting
  • Preparation Of Water Soluble Compounds Through Salt Formation
  • Preparation Of Water-Soluble Compounds By Covalent Attachment Of Solubilizing Moieties
  • Drug Solubilization With Organic Solvents, Surfactants And Lipids
  • Improvement Of Drug Properties By Cyclodextrins
  • Chemical And Physicochemical Solutions To Formulation Problems
  • Discover A Drug Substance, Formulate And Develop It To A Product
  • Drug Nomenclature
  • Legal Aspects Of Product Protection
  • The Consumption And Production Of Pharmaceuticals.

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