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Adenoviral vectors for gene therapy /
Adenoviral Vectors for Gene Therapy provides detailed and comprehensive coverage of these important therapeutic agents. The topics covered in this book range from the basic biology of adenoviruses, through the construction and purification of adenoviral vectors, cutting-edge vectorology and the use...
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | , |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Amsterdam ; Boston :
Academic Press,
�2002.
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| Temas: | |
| Acceso en línea: | Texto completo |
MARC
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| 245 | 0 | 0 | |a Adenoviral vectors for gene therapy / |c edited by David T. Curiel, Joanne T. Douglas. |
| 260 | |a Amsterdam ; |a Boston : |b Academic Press, |c �2002. | ||
| 300 | |a 1 online resource (xxviii, 677 pages) : |b illustrations | ||
| 336 | |a text |b txt |2 rdacontent | ||
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| 520 | |a Adenoviral Vectors for Gene Therapy provides detailed and comprehensive coverage of these important therapeutic agents. The topics covered in this book range from the basic biology of adenoviruses, through the construction and purification of adenoviral vectors, cutting-edge vectorology and the use of adenoviral vectors in preclinical animal models, to regulatory issues which must be considered prior to the initiation of human clinical gene therapy trials. The broad scope of this unique volume provides the reader with a complete understanding of the development and use of adenoviral vectors. Key Features * Provides complete coverage of basic biology of adenoviruses, as well as the construction, propagation and purification of adenoviral vectors * Introduces common strategies for the development of adenoviral vectors along with cutting-edge methods for their improvement * Demonstrates noninvasive imaging of adenovirus-mediated gene transfer * Discusses utility of adenoviral vectors in animal disease models * Considers Federal Drug Administration regulations for human clinical trials. | ||
| 505 | 0 | |a Adenovirus Structure -- Biology of Adenovirus Cell Entry -- Adenovirus Replication -- Adenoviral Vector Construction I: Mammalian Systems -- Adenoviral Vector Construction II: Bacterial Systems -- Propagation of Adenoviral Vectors: Use of PER. C6 Cells -- Purification of Adenovirus -- Targeted Adenoviral Vectors I: Transductional Targeting -- Targeted Adenoviral Vectors II: Transcriptional Targeting -- Development of Attenuated Replication Competent Adenoviruses ARCAs) for the treatment of Prostate Cancer -- Replication-Selective Oncolytic Adenovirus EI-Region Mutants: Virotherapy for Cancer -- Innate Immune Responses to in Vivo Adenovirus Infection -- Humoral Immune Response -- Novel Methods to Eliminate the Immune Response to Adenovirus Gene Therapy -- High-Capacity "Gutless" Adenoviral Vectors: Technical Aspects and Applications -- Xenogenic Adenoviral Vectors -- Hybrid Adenoviral Vectors -- Utility of Adenoviral Vectors in Animal Models of Human Disease I: Cancer -- Utiltity of Adenoviral Vectors in Animal Models of Human Disease II: Genetic Disease -- Utility of Adenoviral Vectors in Animal Models of Human Disease III: Acquired Diseases -- Testing of Adenoviral Vector Gene Transfer Products: FDA Expectations -- Imaging Adenovirus-Medicated Gene Transfer. | |
| 504 | |a Includes bibliographical references. | ||
| 588 | 0 | |a Print version record. | |
| 546 | |a English. | ||
| 650 | 0 | |a Gene therapy. | |
| 650 | 0 | |a Adenoviruses. | |
| 650 | 1 | 2 | |a Genetic Therapy |x methods |0 (DNLM)D015316Q000379 |
| 650 | 2 | |a Genetic Therapy |0 (DNLM)D015316 | |
| 650 | 2 | 2 | |a Adenoviridae |0 (DNLM)D000256 |
| 650 | 2 | 2 | |a Genetic Vectors |x therapeutic use |0 (DNLM)D005822Q000627 |
| 650 | 6 | |a Th�erapie g�enique. |0 (CaQQLa)201-0193146 | |
| 650 | 6 | |a Ad�enovirus. |0 (CaQQLa)201-0061725 | |
| 650 | 7 | |a HEALTH & FITNESS |x Diseases |x Genetic. |2 bisacsh | |
| 650 | 7 | |a MEDICAL |x Genetics. |2 bisacsh | |
| 650 | 7 | |a Adenoviruses |2 fast |0 (OCoLC)fst00796586 | |
| 650 | 7 | |a Gene therapy |2 fast |0 (OCoLC)fst00939638 | |
| 650 | 7 | |a Adenov�irus. |2 larpcal | |
| 650 | 7 | |a Genes virais. |2 larpcal | |
| 650 | 7 | |a V�irus de dna. |2 larpcal | |
| 700 | 1 | |a Curiel, David. | |
| 700 | 1 | |a Douglas, Joanne T. | |
| 776 | 0 | 8 | |i Print version: |t Adenoviral vectors for gene therapy. |d Amsterdam ; Boston : Academic Press, �2002 |z 0121995046 |z 9780121995041 |w (DLC) 2001098272 |w (OCoLC)49780706 |
| 856 | 4 | 0 | |u https://sciencedirect.uam.elogim.com/science/book/9780121995041 |z Texto completo |