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Anticancer drug development /
Here in a single source is a complete spectrum of ideas on the development of new anticancer drugs. Containing concise reviews of multidisciplinary fields of research, this book offers a wealth of ideas on current and future molecular targets for drug design, including signal transduction, the cell...
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | , |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
San Diego :
Academic Press,
�2002.
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| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- A brief history of cancer chemotherapy
- Novel targets in the cell cycle and cell cycle checkpoints
- Growth factor and signal transduction targets for cancer therapy
- Cell death pathways as targets for anticancer drugs
- Drug resistance pathways as targets
- Role of matrix metalloproteinases and plasminogen activators in cancer invasion and metastasis: therapeutic strategies
- Tumor vasculature as a target
- Gene-directed enzyme prodrug therapy
- Tumor antigens as targets for anticancer drug development
- Structure-based drug design and its contributions to cancer chemotherapy
- The contribution of synthetic organic chemistry to anticancer drug development
- Biosynthetic products for anticancer drug design and treatment: the bryostatins
- DNA-encoded peptide libraries and drug discovery
- Mechanism-based high-throughput screening for novel anticancer drug discovery
- Tumor cell cultures in drug development
- Screening using animal systems
- Relevance of preclinical pharmacology and toxicology to Phase I trial extrapolation techniques: relevance of animal toxicity
- Clinical trial design: incorporation of pharmacokinetic, pharmacodynamic, and pharmacogenetic principle
- Tumor imaging applications in the testing of new drugs
- Mechanistic approaches to Phase I clinical trials.