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Advances in cancer research. Volume 77 /
Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. Here once again, outstanding and original reviews are presented. Key Features * The Yin Yang of TCF/b-Catenin Signalling * Biochemical and Clinical Implications of the Erb/HER Signal...
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | , |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
San Diego :
Academic Press,
�2000.
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| Temas: | |
| Acceso en línea: | Texto completo Texto completo |
Tabla de Contenidos:
- Front Cover; Advances in Cancer Research, Volume 77; Copyright Page; Contents; Contributors to Volume 77; Chapter 1. The Yin-Yang of TCF/�-Catenin Signaling; I. An Introduction to the Tcf Family; II. The HMG Box: DNA Binding and Bending; III. Context-Dependent Transactivation; IV. Functions of the Tcfs in Mammalian Development; V. Wingless/Wnt Signaling Pathways; VI. Tcf/�-Catenin Complexes: Bipartite Transcription Factors Involved in Wingless/Wnt Signaling; VII. Regulation of Tcf/�-Catenin Signaling; VIII. Regulation of Wingless/Wnt Target Genes by Tcfs: Activation versus Repression
- IX. Tcf/�-Catenin Signaling and CancerReferences; Chapter 2. Biochemical and Clinical Implications of the ErbB/HER Signaling Network of Growth Factor Receptors; I. Introduction; II. Clinical Aspects of ErbB Receptors; III. How Does ErbB-2 Induce Cancer?; IV. Evolutionary and Developmental Aspects of the Multiplicity of ErbB Proteins; V. The ErbB Signaling Network; VI. ErbB-Directed Cancer Therapy; VII. Conclusions; References; Chapter 3. p53 and Human Cancer: The First Ten Thousand Mutations; I. Introduction; II. Biology of the p53 Protein; III. Mutations and Variations in the p53 Gene
- IV. p53 Mutations in Sporadic Cancers: Host-Environment InteractionsV. Clinical Relevance of p53 Mutations; References; Chapter 4. Macrophage Stimulating Protein; I. Introduction; II. Structural Aspects of Native and Recombinant pro-MSP; III. Binding of MSP to Its Receptor; IV. A Model of MSP-Induced Receptor Dimerization; V. Regulation of MSP Activity: Pathways for pro-MSP Cleavage; VI. MSP-Ron Signaling; VII. Modes of MSP Receptor Regulation or Activation; VIII. Target Cells for Macrophage Stimulating Protein; IX. Perspective; References
- Chapter 5. CD44 Glycoproteins in Colorectal Cancer: Expression, Function, and Prognostic ValueI. Introduction; II. Structure and Function of CD44; III. CD44 in Tumor Progression and Metastasis; IV. Conclusions; References; Chapter 6. A Simple Model for Carcinogenesis of Colorectal Cancers with Microsatellite Instability; I. Introduction; II. A Simple Model of RER+ Tumor Carcinogenesis; III. Evidence to Support the Model; IV. Discussion; V. Conclusion; References; Index