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Advances in cancer research. Volume 77 /

Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. Here once again, outstanding and original reviews are presented. Key Features * The Yin Yang of TCF/b-Catenin Signalling * Biochemical and Clinical Implications of the Erb/HER Signal...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Vande Woude, George F., Klein, George, 1925-2016
Formato: Electrónico eBook
Idioma:Inglés
Publicado: San Diego : Academic Press, �2000.
Temas:
Acceso en línea:Texto completo
Texto completo

MARC

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245 0 0 |a Advances in cancer research.  |n Volume 77 /  |c edited by George F. Vande Woude, George Klein. 
260 |a San Diego :  |b Academic Press,  |c �2000. 
300 |a 1 online resource (vii, 229 pages) :  |b illustrations 
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504 |a Includes bibliographical references and index. 
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520 |a Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. Here once again, outstanding and original reviews are presented. Key Features * The Yin Yang of TCF/b-Catenin Signalling * Biochemical and Clinical Implications of the Erb/HER Signaling Network of Growth Factor Receptors * p53 and Human Cancer: The First Ten Thousand Mutations * Macrophage Stimulating Protein * CD44 Glycoproteins in Colorectal Cancer; Expression; Function; and Prognostic Value * A Simple Modes for Carcinogenesis of Colorectal Cancer with Microsatellite Instability. 
505 0 |a Front Cover; Advances in Cancer Research, Volume 77; Copyright Page; Contents; Contributors to Volume 77; Chapter 1. The Yin-Yang of TCF/�-Catenin Signaling; I. An Introduction to the Tcf Family; II. The HMG Box: DNA Binding and Bending; III. Context-Dependent Transactivation; IV. Functions of the Tcfs in Mammalian Development; V. Wingless/Wnt Signaling Pathways; VI. Tcf/�-Catenin Complexes: Bipartite Transcription Factors Involved in Wingless/Wnt Signaling; VII. Regulation of Tcf/�-Catenin Signaling; VIII. Regulation of Wingless/Wnt Target Genes by Tcfs: Activation versus Repression 
505 8 |a IX. Tcf/�-Catenin Signaling and CancerReferences; Chapter 2. Biochemical and Clinical Implications of the ErbB/HER Signaling Network of Growth Factor Receptors; I. Introduction; II. Clinical Aspects of ErbB Receptors; III. How Does ErbB-2 Induce Cancer?; IV. Evolutionary and Developmental Aspects of the Multiplicity of ErbB Proteins; V. The ErbB Signaling Network; VI. ErbB-Directed Cancer Therapy; VII. Conclusions; References; Chapter 3. p53 and Human Cancer: The First Ten Thousand Mutations; I. Introduction; II. Biology of the p53 Protein; III. Mutations and Variations in the p53 Gene 
505 8 |a IV. p53 Mutations in Sporadic Cancers: Host-Environment InteractionsV. Clinical Relevance of p53 Mutations; References; Chapter 4. Macrophage Stimulating Protein; I. Introduction; II. Structural Aspects of Native and Recombinant pro-MSP; III. Binding of MSP to Its Receptor; IV. A Model of MSP-Induced Receptor Dimerization; V. Regulation of MSP Activity: Pathways for pro-MSP Cleavage; VI. MSP-Ron Signaling; VII. Modes of MSP Receptor Regulation or Activation; VIII. Target Cells for Macrophage Stimulating Protein; IX. Perspective; References 
505 8 |a Chapter 5. CD44 Glycoproteins in Colorectal Cancer: Expression, Function, and Prognostic ValueI. Introduction; II. Structure and Function of CD44; III. CD44 in Tumor Progression and Metastasis; IV. Conclusions; References; Chapter 6. A Simple Model for Carcinogenesis of Colorectal Cancers with Microsatellite Instability; I. Introduction; II. A Simple Model of RER+ Tumor Carcinogenesis; III. Evidence to Support the Model; IV. Discussion; V. Conclusion; References; Index 
546 |a English. 
650 0 |a Cancer  |x Research. 
650 6 |a Cancer  |x Recherche.  |0 (CaQQLa)201-0004697 
650 7 |a MEDICAL  |x Oncology.  |2 bisacsh 
650 7 |a HEALTH & FITNESS  |x Diseases  |x Cancer.  |2 bisacsh 
650 7 |a Cancer  |x Research.  |2 fast  |0 (OCoLC)fst00845497 
655 4 |a Electronic books. 
700 1 |a Vande Woude, George F. 
700 1 |a Klein, George,  |d 1925-2016. 
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