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020 |a 0123737370  |q (electronic bk.) 
020 |a 9780123737373  |q (electronic bk.) 
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082 0 4 |a 616.898  |2 22 
245 0 0 |a Integrating the Neurobiology of Schizophrenia /  |c edited by Anissa Abi-Dargham, Olivier Guillin. 
264 1 |a Amsterdam ;  |a Boston :  |b Elsevier,  |c 2007. 
300 |a 1 online resource (xvi, 459 pages) :  |b illustrations (some color) 
336 |a text  |b txt  |2 rdacontent 
337 |a computer  |b c  |2 rdamedia 
338 |a online resource  |b cr  |2 rdacarrier 
490 1 |a International review of neurobiology ;  |v v. 78 
546 |a Text in English. 
504 |a Includes bibliographical references and index. 
505 0 |a Cover -- Copyright Page -- Contents -- Contributors -- Preface -- References -- Chapter 1: Neurobiology of Dopamine in Schizophrenia -- I. Introduction -- II. Dopaminergic System in the Brain -- A. Dopaminergic Projections -- B. Dopaminergic Receptors -- III. Evidence Supporting Alterations of DA Systems in Schizophrenia -- A. Pharmacological Evidence -- B. Postmortem Studies -- C. Imaging Studies -- IV. Conclusions -- References -- Chapter 2: The Dopamine System and the Pathophysiology of Schizophrenia: A Basic Science Perspective -- I. Introduction -- II. Neuroanatomy of DA Systems -- III. DA Neuron Activity and Release -- IV. Cellular Actions of DA -- V. Roles of DA on Cognitive and Affective Functions -- VI. Development and Maturation of the DA System -- VII. DA Deficits in Schizophrenia -- VIII. Conclusions -- References -- Chapter 3: Glutamate and Schizophrenia: Phencyclidine, N-Methyl-D-Aspartate Receptors, and Dopamine-Glutamate Interactions -- I. Introduction -- II. Glutamatergic Physiology -- A. Glutamate-Dopamine Comparisons -- B. Glutamate Receptors -- C. NMDA Receptors -- D. AMPA/Kainate Receptors -- E. Metabotropic Receptors -- III. Glutamatergic Models of Schizophrenia -- A. Symptom Patterns Following NMDA Antagonist Administration -- B. Cognitive Deficits Following NMDA Antagonist Treatment -- C. In Vivo Findings in Schizophrenia Based on Dopamine Receptor Occupancy -- D. Postmortem Findings -- IV. Clinical Studies with NMDA Agonists -- A. NMDA Receptor Glycine-Site Agonists -- B. Glycine Transport Inhibitors -- C. Other Ionotropic Targets -- D. Metabotropic Receptors -- E. Group I Receptors -- F. Group II Metabotropic Agonists -- V. Potential Causes of Glutamatergic Dysfunction in Schizophrenia -- A. Dopamine-Glutamate Interactions -- B. Linkage-Association Studies in Schizophrenia -- C. Environmental and Neurochemical Factors -- VI. Future Research and Treatment Implications -- Acknowledgments -- References -- Chapter 4: Deciphering the Disease Process of Schizophrenia: the. Contribution of Cortical Gaba Neurons -- I. Working Memory Impairments: A Core Feature of Schizophrenia -- II. Working Memory Impairments and Altered GABA Neurotransmission in the DLPFC -- III. Potential Pathogenetic Mechanisms for Cell Type-Specific Alterations in GABA Neurons -- A. Reduced Excitatory Drive via NMDA Receptors -- B. Reduced Neurotrophin Signaling -- IV. Connecting Alterations in PV-Positive Neurons to Working Memory Impairments: Decreased Gamma Band Synchrony in Schizophrenia -- V. Treatment Implications -- Acknowledgments -- References -- Chapter 5: Alterations of Serotonin Transmission in Schizophrenia -- I. Introduction -- II. Alteration of 5-HT Receptors in Schizophrenia -- A. 5-HT Transporters -- B. 5-HT1A Receptors -- C. 5-HT2 Receptors -- D. Other Receptors -- III. Pharmacological Manipulation of 5-HT Transmission in Schizophrenia -- A. 5-HT Precursors -- B. 5-HT Depleting Agents -- C. 5-HT2A Agonism: LSD and "Model&#3. 
520 |a A thorough overview of all neurotransmitters involved in schizophrenia. 
588 0 |a Print version record. 
650 0 |a Schizophrenia  |x Physiological aspects. 
650 0 |a Schizophrenia  |x Chemotherapy. 
650 2 |a Schizophrenia  |x drug therapy  |0 (DNLM)D012559Q000188 
650 2 |a Schizophrenia  |x physiopathology  |0 (DNLM)D012559Q000503 
650 6 |a Schizophr�enie  |x Chimioth�erapie.  |0 (CaQQLa)201-0020954 
650 7 |a PSYCHOLOGY  |x Psychopathology  |x Schizophrenia.  |2 bisacsh 
650 7 |a Schizophrenia  |x Chemotherapy  |2 fast  |0 (OCoLC)fst01106753 
650 7 |a Schizophrenia  |x Physiological aspects  |2 fast  |0 (OCoLC)fst01106768 
653 0 0 |a schizofrenie 
653 0 0 |a schizophrenia 
653 0 0 |a geestelijke stoornissen 
653 0 0 |a mental disorders 
653 0 0 |a neurofysiologie 
653 0 0 |a neurophysiology 
653 0 0 |a neurologie 
653 0 0 |a neurology 
653 0 0 |a neurotransmitters 
653 0 0 |a cannabinoids 
653 0 0 |a neurobiologie 
653 0 0 |a neurobiology 
653 1 0 |a Human Pathology 
653 2 0 |a Neurophysiology 
653 1 0 |a Humane pathologie 
653 2 0 |a Neurofysiologie 
700 1 |a Abi-Dargham, Anissa,  |e editor. 
700 1 |a Guillin, Olivier,  |e editor. 
776 0 8 |i Print version:  |t Integrating the neurobiology of schizophrenia.  |d Amsterdam ; Boston : Elsevier, �2007  |z 0123737370  |z 9780123737373  |w (OCoLC)122378591 
830 0 |a International review of neurobiology ;  |v v. 78. 
856 4 0 |u https://sciencedirect.uam.elogim.com/science/book/9780123737373  |z Texto completo 
856 4 0 |u https://sciencedirect.uam.elogim.com/science/bookseries/00747742/78  |z Texto completo 
856 4 0 |u https://sciencedirect.uam.elogim.com/science/bookseries/00747742  |z Texto completo