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Respiratory syncytial virus /
Respiratory syncytial virus (RSV) was first identified half a century ago in 1956. Following its discovery, the virus soon became recognised as a major viral pathogen causing extensive outbreaks of respiratory tract infections in both the very young and in vulnerable adults. It is an unusual virus i...
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Amsterdam ; London :
Elsevier,
2007.
|
| Edición: | 1st ed. |
| Colección: | Perspectives in medical virology ;
v. 14. |
| Temas: | |
| Acceso en línea: | Texto completo Texto completo Texto completo Texto completo |
Tabla de Contenidos:
- Cover
- Respiratory Syncytial Virus
- Copyright Page
- Contents
- Preface
- Molecular Biology of Human Respiratory Syncytial Virus
- Introduction
- The virion
- The infectious cycle
- Experimental systems to study the replicative cycle of HRSV
- Virus entry
- Transcription and replication of the viral genome
- Virus assembly
- Virus-host cell interactions
- Acknowledgements
- References
- Immunology of RSV
- The innate immune response
- The adaptive immune response
- Conclusions
- References
- Molecular Epidemiology and Evolution of RSV
- Introduction
- RSV groups and genotypes
- Structure of epidemics
- Geographic distribution of RSV strains
- The G protein
- Evolution of RSV
- Emergence of new lineages
- Disappearance of lineages
- Mechanism of selection of new strains
- Paradox
- Reinfection with RSV
- Conclusions
- References
- Genetic Susceptibility to RSV Disease
- Epidemiological evidence of genetic susceptibility to RSV infection in infancy
- Evidence that the host response rather than the virus is responsible for disease
- Requirements for effective genetic association studies
- Genetic association studies of RSV bronchiolitis
- Other studies
- General comments
- The future
- References
- Pathogenesis of RSV in Children
- Introduction
- Viral infection and cytotoxicity
- The immune response to infection
- Conclusion
- References
- RSV Infection in Elderly Adults
- Introduction
- Epidemiology
- Clinical manifestations and complications of RSV infection in elderly adults
- Diagnosis of RSV infection
- Treatment of RSV infection
- Prevention of RSV infection
- Conclusions
- References
- Respiratory Syncytial Virus Disease Burden in the Developing World
- Introduction
- Methods, definitions, limitations
- Denominator-based data on incidence
- Associated mortality
- Disease-causing agent or benign co-infection
- Risk factors for RSV infection
- Additional burdens of disease
- Temporal dynamics of RSV: Where and how does it persist
- Conclusions and future research needs
- Abbreviations
- References
- Vaccines against Human Respiratory Syncytial Virus
- Introduction: the burden of disease and the need for a vaccine
- Considerations in developing an RSV vaccine
- Formalin-inactivated RSV (FI-RSV)
- Subunit vaccines
- Live-attenuated RSV strains
- Live-vectored RSV vaccines
- DNA vaccines
- Perspective
- Acknowledgment
- References
- Development of Antivirals against Respiratory Syncytial Virus
- Introduction
- Slow progress
- Vaccines versus antivirals
- Brief history of RSV antiviral development
- Modern approaches to antiviral discovery
- Models of RSV disease
- Alternative model of human RSV in tissue culture
- Clinical trials of RSV agents
- Drugs in development
- Miscellaneous (unknown) mechanisms
- Inhibiting host cell functions
- Antisense compounds and siRNA
- Future prospects
- Acknowledgements
- References
- Pneumonia Virus of Mice
- The natural history of PVM
- Characteristics of the PVM virion
- The molecular biology of PVM
- PVM proteins
- Pathogenesis of PVM infection in inbred strains of mice: basic biology
- Explorations with the PVM infection model: therapeutic directions
- References.