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The neurobiology of epilepsy and aging /
Discusses all aspects of epilepsy in aging patients.
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Amsterdam ; Boston :
Academic Press,
�2007.
|
| Colección: | International review of neurobiology ;
v. 81. |
| Temas: | |
| Acceso en línea: | Texto completo Texto completo Texto completo |
Tabla de Contenidos:
- Cover
- Copyright Page
- Dedication Page
- Contents
- Contributors
- Acknowledgment
- Chapter 1: Epilepsy in the Elderly: Scope of the Problem
- I. Introduction
- II. Known Knowns
- A. Incidence and Prevalence of Epilepsy Is Higher in the Community-Dwelling Elderly Than in Younger Adults or Children
- B. Prevalence and Incidence of Epilepsy Is Higher Among Nursing Home Residents Than Community-Dwelling Elderly
- C. Retirement Age of 65 Is a Political Decision, Not Related to Medical Condition
- D. The Elderly Are Not a Homogeneous Group
- E. Patterns of AED Use Differ Markedly Between Countries and Between Community-Dwelling and Nursing Home Elderly
- F. In Nursing Homes, the Young-Old are More Likely to Use an AED than the Old-Old
- G. Causes of Epilepsy in the Elderly
- H. Many Seizures in the Elderly are not Epileptic
- I. AED Pharmacology Is Different in the Elderly
- J. Choosing AEDs for an Elderly Person Is Difficult
- K. Drug Interactions With Non-AEDs Are a Major Problem
- III. Known Unknowns
- IV. Unknown Unknowns
- V. Unknown Knowns
- A. The "Therapeutic" Range of Total Phenytoin is 10-20 mg/liter
- B. AED Levels Are Stable Over Time With Constant Doses
- VI. Conclusion
- References
- Chapter 2: Animal Models in Gerontology Research
- I. Animal Models in Aging Research: Considerations for Experimental Design
- II. The Age Factor
- III. Genetic Background
- IV. Choice of Strain
- V. Environmental Influences
- VI. Genomic Manipulations
- VII. Resources
- References
- Chapter 3: Animal Models of Geriatric Epilepsy
- I. Introduction
- II. Mouse Models
- A. Senescence-Accelerated Mouse
- B. Cacnb4 (lh) Mouse
- C. MTIII( -/- ) Mouse
- D. El Mouse
- E. DBA Mouse
- F. Acute Seizure Models in Common Strains
- III. Gerbil Model
- IV. Rat Models
- A. Acute Seizure Models
- B. Lesion Models
- C. Chronic Epilepsy Models
- V. Conclusions
- References
- Chapter 4: Life and Death of Neurons in The Aging Cerebral Cortex
- I. Introduction
- II. Cortical Circuitry and Alzheimer's Disease
- A. Overview
- B. Hippocampal Pathology in AD
- C. Neocortical Pathology in AD
- D. Neurofilament Protein Is a Marker of Neuronal Vulnerability in AD
- E. Summary: AD and Cortical Circuitry
- III. AAMI: Functional Decline Without Neuron Loss
- A. Introduction
- B. The Aging Cerebral Cortex: Nonhuman Primate Studies
- IV. Interactions Between Neural and Endocrine Senescence
- V. Conclusions
- Acknowledgments
- References
- Chapter 5: An In Vitro model of Stroke-Induced Epilepsy: Elucidation of the Roles of Glutamate and Calcium in the Induction and Maintenance of Stroke-Induced Epileptogenesis
- I. Introduction
- II. Role of Glutamate in the Pathophysiology of Stroke
- III. Developing an In Vitro Model of Glutamate Injury That Causes a Mixed Population of Injured and Dead Neurons in Preparations of Hippocampal Neurons in Culture
- IV. Development of SREDs in Neurons Surviving Injury
- V. Neuronal Networks Di.