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DNA repair. Part A /
This volume provides detailed coverage of modern methods for molecular analysis of enzymes and enzyme systems that function in the maintenance of genome integrity. Coverage areas include base excision repair, nucleotide excision repair, translesion DNA polymerases, mismatch repair, genetic recombina...
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | , |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Amsterdam ; Boston :
Elsevier/Academic Press,
�2006.
|
| Colección: | Methods in enzymology ;
v. 408. |
| Temas: | |
| Acceso en línea: | Texto completo Texto completo |
MARC
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| 245 | 0 | 0 | |a DNA repair. |n Part A / |c edited by Judith Campbell, Paul Modrich. |
| 260 | |a Amsterdam ; |a Boston : |b Elsevier/Academic Press, |c �2006. | ||
| 300 | |a 1 online resource (xxxv, 582 pages) : |b illustrations | ||
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| 490 | 1 | |a Methods in enzymology ; |v v. 408 | |
| 504 | |a Includes bibliographical references and indexes. | ||
| 588 | 0 | |a Print version record. | |
| 520 | |a This volume provides detailed coverage of modern methods for molecular analysis of enzymes and enzyme systems that function in the maintenance of genome integrity. Coverage areas include base excision repair, nucleotide excision repair, translesion DNA polymerases, mismatch repair, genetic recombination, and double strand break repair. *A laboratory standard for more than 40 years *Over 400 volumes strong *Also available on <a href="http://www.sciencedirect.com">ScienceDirect</a> *Part A of a 2-part series | ||
| 505 | 8 | |6 880-01 |a 5. The LXRs are anti-atherosclerotic and anti-inflammatory factors6. Cross-talk between the LXRs and other NRs regulates overall body homeostasis; 7. Perspectives; References; Chapter 5. SREBP-1c regulation of nutrient homeostasis and lipid accumulation; 1. Introduction; 2. Structure, genes and tissue distribution of SREBP isoforms; 3. Regulation of SREBP-1c transcriptional activity; 4. SREBP target genes; 5. Mechanisms involved in glucose action: involvement of the ''Carbohydrate Response Element Binding Protein'' transcription factor; 6. SREBPs and physiopathology; 7. Conclusion. | |
| 505 | 8 | |a AcknowledgmentsReferences; Chapter 6. The adipocyte and adipose tissue as endocrine organs: Impact on the insulin resistance phenotype; 1. Embryonic development of adipose tissue and the role of angiogenesis; 2. Expansion of adiose tissue mass: hypertrophy versus hyperplasia and impact on adipocyte function; 3. Adipose tissue distribution and its relation to metabolism-depot specificity; 4. Impact of PPAR agonists on adipokines in disease states; References; Chapter 7. FOXC2 in the adipocyte; 1. Introduction; 2. The gene and its expression profile; 3. Function in metabolism. | |
| 505 | 8 | |a 4. Regulation of FOXC25. WAT versus BAT; 6. Protection against diet-induced insulin resistance; 7. Human data; 8. The autonomic nervous system; 9. Future; Acknowledgment; References; Chapter 8. Regulation of adipocyte differentiation and metabolism by Wnt signaling and C/EBP transcription factors; 1. Introduction; 2. Roles for Wnt signaling in adipogenesis and glucose homeostasis; 3. Role of C/EBPS in hepatocyte differentiation and liver metabolism; 4. Roles for C/EBPs in adipocyte differentiation and metabolism; Acknowledgments; References. | |
| 650 | 0 | |a Enzymology. | |
| 650 | 0 | |a DNA repair. | |
| 650 | 2 | |a DNA Repair |0 (DNLM)D004260 | |
| 650 | 6 | |a ADN |x R�eparation. |0 (CaQQLa)201-0047976 | |
| 650 | 6 | |a Enzymologie. |0 (CaQQLa)201-0269407 | |
| 650 | 7 | |a SCIENCE |x Life Sciences |x Biochemistry. |2 bisacsh | |
| 650 | 7 | |a DNA repair |2 fast |0 (OCoLC)fst00886599 | |
| 650 | 7 | |a Enzymology |2 fast |0 (OCoLC)fst00913635 | |
| 700 | 1 | |a Campbell, Judith L. | |
| 700 | 1 | |a Modrich, Paul. | |
| 776 | 0 | 8 | |i Print version: |t DNA repair. Part A. |d Amsterdam ; Boston : Elsevier/Academic Press, �2006 |z 0121828131 |z 9780121828134 |w (OCoLC)68810474 |
| 830 | 0 | |a Methods in enzymology ; |v v. 408. | |
| 856 | 4 | 0 | |u https://sciencedirect.uam.elogim.com/science/book/9780121828134 |z Texto completo |
| 856 | 4 | 0 | |u https://sciencedirect.uam.elogim.com/science/bookseries/00766879/408 |z Texto completo |
| 880 | 0 | |6 505-00/(S |a Cover; Contents; Preface; List of contributors; Chapter 1. Transcription factor genes in type 2 diabetes; 1. Introduction; 2. The PPARG gene; 3. Maturity onset diabetes of the young (MODY); 4. Transcription factor MODY genes; 5. Conclusion; Acknowledgements; References; Chapter 2. PPARγ, a key therapeutic target in the metabolic syndrome -- unique insights derived from the study of human genetic variants; 1. Introduction; 2. PPARγ -- a 'metabolic' nuclear receptor; 3. PPARγ -- human genetic variants; 4. PPARγ -- a rational therapeutic target in the human metabolic syndrome. | |
| 880 | 8 | |6 505-01/(S |a 5. Conclusions and future directionsReferences; Chapter 3. PPARδ: Emerging therapeutic potential of novel agonists in lipid and glucose homeostasis; 1. Introduction; 2. PPARδ: the rise of an abandoned orphan; 3. PPARδ in lipid and carbohydrate metabolism: a potential phoenix from the ashes; Acknowledgements; References; Chapter 4. Liver X receptors as potential drug targets for diabetes and its disorders; 1. Introduction to LXR; 2. LXR signaling in carbohydrate metabolism; 3. LXR signaling in lipid and cholesterol metabolism; 4. The LXRs control energy homeostasis. | |