GTPases regulating membrane targeting and fusion /

Rab GTPases now comprise a family of>63 members. They are emerging as the key hub element controlling the membrane architecture of eukaryotic cells. They are intimately involved in vesicle targeting and fusion in both the endocytic and exocytic pathways and direct the assembly and disassembly of...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Balch, William Edward, 1949- (Editor ), Der, Channing J. (Editor ), Hall, A. (Alan) (Editor )
Formato: Electrónico eBook
Idioma:Inglés
Publicado: San Diego, California : Elsevier Academic Press, �2005.
Colección:Methods in enzymology ; v. 403.
Temas:
Cellular control mechanisms.
Enzymes.
Membrane fusion.
Membranes (Biology)
GTP Phosphohydrolases > metabolism
Cell Membrane > metabolism
Membrane Fusion
Enzymes
Membranes
R�egulation cellulaire.
Fusion membranaire.
Membranes (Biologie)
enzyme.
Cellular control mechanisms
Membrane fusion
Biologie
Regulation
Membranfusion
Guanosintriphosphatasen
GTPasen.
Regelmechanismen.
Membranen.
fosfoglyceraat kinase (gtp)
phosphoglycerate kinase (gtp)
celmembranen
cell membranes
Proteins and Enzymes
Eiwitten en enzymen
Periodicals
Acceso en línea:Texto completo
Texto completo
Texto completo
Descripción
Sumario:Rab GTPases now comprise a family of>63 members. They are emerging as the key hub element controlling the membrane architecture of eukaryotic cells. They are intimately involved in vesicle targeting and fusion in both the endocytic and exocytic pathways and direct the assembly and disassembly of protein complexes that include regulators (GEFs and GAPs), effectors (tethers/motors) and fusion components (SNAREs) that control membrane targeting and fusion. During the last 3 years the field has virtually exploded with the identification and characterization of many new Rab proteins and their effectors. Our understanding of how Rab GTPases control membrane function remains at its infancy. This volume of MIE provides a wealth of new concepts, approaches and tools to study Rab proteins in the test tube and in living cells that will be of strong benefit to both established laboratories and new investigators in the field to elucidate Rab GTPase function in cellular development, differentiation and proliferation. * Comprehensive overview of Rab GTPase phylogeny and systems biology * Identification and characterization of Rab GEFs, GAPs and effectors * General methodologies to study Rab GTPase function in vitro and in vivo using biochemical, molecular and microscopy approaches.
Descripción Física:1 online resource (xliii, 863 pages, 28 unnumbered pages of plates) : illustrations (some color)
Bibliografía:Includes bibliographical references and index.
ISBN:0121828085
9780121828080
ISSN:0076-6879 ;

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