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Developments in tissue engineered and regenerative medicine products : a practical approach /
Developments in tissue engineered and regenerative medicine products summarizes recent developments in tissue engineering and regenerative medicine with an emphasis on commercialization and product development. Features of current cell therapy and tissue engineered products which have facilitated su...
| Clasificación: | Libro Electrónico |
|---|---|
| Autores principales: | , |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Cambridge :
Woodhead Pub.,
2012.
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| Colección: | Woodhead Publishing series in biomaterials ;
no. 48. |
| Temas: | |
| Acceso en línea: | Texto completo (Requiere registro previo con correo institucional) |
Tabla de Contenidos:
- Cover; Dedication; Developments in tissue engineered and regenerative medicine products: A practical approach; Copyright; Contents; List of figures, tables and boxes; About the authors; Woodhead Publishing Series in Biomaterials; Preface; Acknowledgements; 1 Overview of tissue engineering/ regenerative medicine; 1.1 Introduction; 1.2 Cells; 1.3 Biomaterials; 1.4 Therapeutic product delivery; References; 2 Cells; 2.1 Introduction; 2.2 Mechanism of action of cell-based therapeutics; 2.3 Other stem cell-based therapeutics currently under development.
- 2.4 Development of genome modification technologies: gene-based cell therapies2.5 Committed cell types: ideal candidates for TE/RM product development; 2.6 Summary: key features favoring commercial development of cellular ABIs; References; 3 Biomaterials for TE/RM products; 3.1 Introduction; 3.2 The ECM: comparator for biomaterials; 3.3 Decell/recell: the ultimate biomaterial platform?; 3.4 Selection of biomaterials for tissue engineering: illustrative example
- kidney; 3.5 Biomaterials candidates for renal tissue engineering.
- 3.6 Selection of biomaterials for tubular organs: bladder, esophagus and small intestineReferences; 4 Neo-Bladder: a foundational technology platform for tubular organ regeneration; 4.1 The need for urinary neo-organs; 4.2 TE/RM methodologies for bladder replacement and augmentation; 4.3 Demonstration of Neo-Bladder formation in large animals; 4.4 Can neo-bladder constructs be made from cells sourced from diseased patients?; 4.5 Neo-bladder replacement in human pediatric patients
- first clinical trials of a neo-organ; 4.6 Making the product: cell sourcing.
- 4.7 Definition of the cell source used for seeding neo-bladders: adipose4.8 Other approaches to tissue engineering neo-bladders; 4.9 Key results from development of the Neo-Bladder: factors facilitating commercial viability of an organ regeneration platform; References; 5 Neo-Urinary ConduitTM; 5.1 Introduction; 5.2 Assembly of the NUC; 5.3 Preclinical evaluation of the NUC; 5.4 Assembly of an NUC cell/scaffold composite; 5.5 GLP preclinical analysis of de novo NUC formation in a porcine cystectomy model; 5.6 Alternate cell sourcing of SMC for seeding of the NUC; 5.7 Clinical trials of the NUC.
- 5.8 Regeneration of muco-cutaneous region at the skin/conduit junction5.9 Speculations for the future; References; 6 Tissue engineering of non-bladder tubular organs; 6.1 Introduction; 6.2 Vasculature; 6.3 Lung; 6.4 Gastrointestinal tract; 6.5 Genito-urinary system; References; 7 Tissue engineering of solid organs; 7.1 Introduction; 7.2 Kidney; 7.3 Heart; 7.4 Liver; 7.5 Pancreas; 7.6 Spleen; 7.7 Central nervous system; 7.8 Summary; References; 8 Regulatory and quality control; 8.1 Good manufacturing practice; 8.2 Good tissue practices.