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Genetics for nurses /
Genetics for Nurses has been designed considering the syllabi requirements laid down by the Indian Nursing Council and the leading nursing colleges. The book has a variety of case studies and review questions to support the theoretical concepts and is an unique offering to the undergraduate students...
| Clasificación: | Libro Electrónico |
|---|---|
| Autor principal: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
New Delhi :
Dorling Kindersley (India)/Pearson,
©2013.
|
| Colección: | Always learning.
|
| Temas: | |
| Acceso en línea: | Texto completo (Requiere registro previo con correo institucional) |
Tabla de Contenidos:
- Cover
- Contents
- Foreword
- Preface
- Acknowledgements
- About the Author
- Chapter 1: Practical Application of Genetics in Nursing and Roles of a Nurse
- Roles of a Nurse
- Career Focus
- Review Question
- Chapter 2: Review of Cellular Division: Mitosis and Meiosis
- Introduction to Prokaryotic and Eukaryotic Cell
- Shape
- Size
- Number
- Cell wall
- Plasma membrane
- Cytoplasm
- Nucleus
- Cell Division
- An Overview of the Cell Cycle
- The Mechanics of Cell Division
- An overview of the M phase
- Cytoskeletal machines perform both mitosis and cytokinesis
- Two mechanisms help ensure that mitosis always precedes cytokinesis
- Mitosis in Detail
- Prophase
- Prometaphase
- Metaphase
- Anaphase
- Telophase
- Cytokinesis
- Meiosis
- Introduction
- Meiosis I
- Interphase I
- Prophase I
- Leptotene
- Zygotene
- Pachytene
- Diplotene
- Diakinesis
- Metaphase I
- Anaphase I
- Telophase I
- Meiosis II
- Interphase II
- Prophase II
- Metaphase II
- Anaphase II
- Review Questions
- Chapter 3: Structure and Organization of Genetic Material
- Characteristics and Structure of DNA and Chromosomes-DNA Packaging and Chromosome Condensation
- Structure of chromosomes
- Chromosomal DNA and its packaging in the chromatin fibre
- Eukaryotic DNA is packaged into a set of chromosomes
- Nucleosomes are the basic unit of eukaryotic chromosome structure
- Forms of chromosomes-metacentric, submetacentric, and acrocentric
- Chromosomes and Sex Determination
- XX-XY sex determination in humans
- The role of sex chromosomes in phenotype and fertility
- Review Questions
- Chapter 4: Errors in Transmission
- Overview of Chromosome Morphology
- Types of chromosome mutations
- Structural chromosomal abnormalities
- Chromosome rearrangements
- Duplications
- Deletions
- Inversions
- Translocations.
- Numerical chromosomal abnormalities
- Aneuploidy
- Types of Aneuploidy
- Aneuploidy in humans
- Polyploidy
- Chromosome mutations and cancer
- Review Questions
- Chapter 5: Classical Genetics: Mendelian Theory of Inheritance
- Principles of Genetics: Mendelian Principles
- Early life of Johann Gregor Mendel (1822-1884)
- Mendel's Experimental Organism: the Pea Plant
- Mendel's Experiment: Monohybrid and Dihybrid Crosses
- Monohybrid cross
- Mendel's conclusions from the monohybrid cross
- Dihybrid cross and the principle of independent assortment
- Review Questions
- Chapter 6: Patterns and Mechanisms of Inheritance in Humans
- Pedigree
- Patterns of Inheritance in Humans
- Autosomal dominant inheritance
- Autosomal recessive inheritance
- X-linked dominant inheritance
- X-linked recessive inheritance
- Y-linked inheritance
- Mitochondrial inheritance
- Multifactorial inheritance
- Review Questions
- Chapter 7: Multiple Alleles and Blood Groups
- The ABO Blood Group
- Function of IA, IB and i Alleles of the ABO Gene
- Other Genetic Systems that Exhibit Multiple Allelism
- Review Questions
- Chapter 8: Prenatal Nutrition
- Maternal Nutritional Status
- Nutritional supplementation during pregnancy
- Physiological changes during pregnancy
- Nutritional requirements during pregnancy
- Food Allergies
- Symptoms
- Some common food allergies
- Diagnostic test available for food allergies
- Review Questions
- Chapter 9: Conditions Affecting the Mother
- Infections During Pregnancy
- Bacterial infections
- Group B beta-hemolytic streptococci (GBS)
- Group A beta-hemolytic streptococcus
- (Streptococcus pyogenes)
- Listeria monocytogenes
- Haemophilus influenzae
- Escherichia coli
- Viral infections
- Rubella
- Cytomegalovirus
- Herpes simplex virus
- Effect of Drugs, Chemicals and Radiation.
- Effect of drugs
- Anticonvulsant drugs
- Phenytoin
- Carbamazepine
- Valproic acid
- Antidepressants
- Lithium
- Isotretinoin
- Coumarin derivatives
- Effects of alcohol
- Spontaneous abortion and stillbirths
- Low birth weight
- Neurobehavioural and neural abnormality
- Neural development
- Prevention
- Effect of chemicals
- Effects of radiation
- Radiobiology
- Effects of ionizing radiation in pregnancy
- Maternal Drug Therapy
- Review Questions
- Chapter 10: Genetic Testing and Diagnosis
- Newborn Screening
- Heterozygote Screening
- Presymptomatic Testing
- Prenatal Genetic Testing and Diagnosis
- Indications for Prenatal Diagnosis (PND)
- Methods of Prenatal Diagnosis
- Principles of Screening Tests
- Non-invasive Testing
- Ultrasound diagnosis of foetal anomalies
- Maternal serum screening
- Triple screening
- Foetal cell sorting
- Invasive Testing
- Amniocentesis
- Chorionic villus sampling
- Cordocentesis
- Preimplantation genetic diagnosis
- Review Questions
- Chapter 11: Impact of Genetic Condition on Families and Genetic Counselling
- Impact of Genetic Condition on Families
- Genetic Counselling
- Genetic services (Counselling and genetic diagnostic testing)
- Presymptomatic testing
- Carrier testing
- Prenatal testing
- Review Questions
- Chapter 12: Consanguinity
- Consanguineous Marriage and Risk of Inheriting Genetic Disorder
- Review Questions
- Chapter 13: Advanced Maternal Age
- Aneuploidies and Advanced Maternal Age
- Older egg model: In advanced maternal age
- Trisomy
- Monosomy
- Mosaicism
- Autosomal Aneuploidies
- Trisomy 21 (Down syndrome)
- Trisomy 18 (Edwards syndrome)
- Trisomy 13 (Patau syndrome)
- Sex Chromosome Aneuploidies
- Monosomy X (Turner syndrome)
- 47,XXY (Klinefelter syndrome)
- Review Questions
- Chapter 14: Down Syndrome (Trisomy 21)
- Overview.
- Genetics of Down Syndrome
- Advanced Maternal Age in Down Syndrome
- Characteristic Features/Phenotype of Down Syndrome
- Medical Conditions Associated with Down Syndrome
- Down Syndrome Management
- Down Syndrome Diagnosis
- Prenatal screening and diagnosis
- Review Questions
- Chapter 15: Infertility
- Factors Affecting Fertility
- Causes of Subfertility-Male and Female Subfertility
- Male Subfertility
- Clinical assessment
- Treatment options for subfertile men
- Female Subfertility
- Chromosomal
- Diagnosis of anovulatory subfertility
- Management of anovulation
- Tubal subfertility
- Causes of tubal damage
- Diagnosis of tubal subfertility
- Endometriosis
- Fibroids
- Assisted Reproductive Techniques
- Review Questions
- Chapter 16: Spontaneous Abortion
- Definition
- Pathophysiology
- Potential causes of spontaneous pregnancy loss
- Mechanism of Abortion
- Incidence
- Clinical Types of Abortion
- Threatened abortion
- Inevitable abortion
- Treatment
- Incomplete abortion
- Treatment
- Complete abortion
- Treatment
- Missed abortion
- Treatment
- Septic abortion
- Treatment
- Risk of Recurrent Pregnancy Loss
- Factors Involved in Recurrent Early Pregnancy Loss
- Foetal death or disease
- Genetic Factors
- Skewed X chromosome inactivation (XCI)
- Premature centromeric division
- Non-genetic Factors
- Anatomical factors
- Endocrine factors
- Infectious factors
- Nutritional causes
- Immunological factors
- Miscellaneous Factors
- Maternal factors
- Male factors
- Indian Scenario
- Detection of recurrent abortions
- Investigation for recurrent pregnancy loss
- Review Questions
- Chapter 17: Congenital Abnormalities, Dysmorphism, and Developmental Delay
- Congenital Abnormalities (Birth Defects) and Dysmorphology
- Clinical Dysmorphology-Classification of Foetal and Birth Defects.
- Malformation
- Deformation
- Disruption
- Dysplasia
- Diagnostic Approach to the Dysmorphic Foetus
- Single-system defect
- Syndrome
- Sequence/cascade
- Teratology
- Environmental risk parameters or modifiers
- Basic Principles of Teratology
- Developmental Milestones
- Normal development
- Developmental delay
- Diagnosis
- Identification
- Developmental disorders
- Learning disability (LD)
- Attention deficit hyperactivity disorder (ADHD)-Behavioural disorder
- Review Questions
- Chapter 18: Neural Tube Defects
- Screening of NTD with Maternal Serum Alpha-Fetoprotein (AFP)
- Ultrasound Evaluation of NTDS
- Prevention of NTD
- Genetic Susceptibility for NTD and Folic Acid Intake
- Fortification During Pregnancy
- Review Questions
- Chapter 19: The Nature of Cancer
- Cancer as a Genetic Disease
- The clonal evolution of tumours
- The role of environment in cancer
- Genes that contribute to cancer
- DNA Repair Genes
- Genes affecting chromosome segregation
- Sequences that regulate telomerase
- Genes that promote vascularization and the spread of tumours
- Chromosome Mutations and Cancer
- The Molecular Genetics of Colorectal Cancer
- Review Questions
- Chapter 20: Inborn Errors of Metabolism
- Classification of Inherited Metabolic Diseases
- Enzyme Defects (Aminoacidopathies)
- Defects in Purine Metabolism (Lesch Nyhan Syndrome)
- Lysosomal Storage Diseases
- Tay Sach's disease
- Mucopolysaccharidoses
- Chapter 21: Haematological Disorders and Genetic Haemochromatosis
- Haemoglobinopathies
- Haemolytic anemias-Sickle cell disease
- Thalassemia
- Alpha thalassemias
- Beta thalassemias
- Genetic Haemochromatosis (GH)
- Review Questions
- Chapter 22: Mental Illness/Mental Disorder
- Normal Mental Health
- Diagnosis
- Management options
- Review Questions
- Chapter 23: The Human Genome Project.