Applied biocatalysis : the chemist's enzyme toolbox /

"Biocatalysis has had a significant impact on the synthesis of active pharmaceutical ingredients (APIs) in recent years. The main driver for this is the ability to harness the regio- and stereoselectivity of enzymes to improve the efficiency of synthetic routes. For example, enzymes can offer d...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Whittall, John (Editor ), Sutton, Peter (Peter W.) (Editor )
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Hoboken, NJ : John Wiley & Sons, Inc., 2021.
Temas:
Biocatalysis.
Biocatalysis
Biocatalyse.
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Cover
  • Title Page
  • Copyright
  • Contents
  • Abbreviations
  • Chapter 1 Directed Evolution of Enzymes Driving Innovation in API Manufacturing at GSK
  • 1.1 Introduction
  • 1.2 Drug Development Stages
  • 1.3 Enzyme Panels
  • 1.4 Enzyme Engineering
  • 1.5 Case Studies
  • 1.6 Outlook
  • Chapter 2 Survey of Current Commercial Enzyme and Bioprocess Service Providers
  • 2.1 Commercial Enzyme Suppliers/Distributors
  • 2.2 Bioprocess Service Providers
  • 2.3 Chemical Transformations of Selected Commercially Available Enzymes
  • Chapter 3 Imine Reductases
  • 3.1 Imine Reductase-Catalysed Enantioselective Reductive Amination for the Preparation of a Key Intermediate to Lysine-Specific Histone Demethylase 1 (LSD1) Inhibitor GSK2879552
  • 3.2 Expanding the Collection of Imine Reductases Towards a Stereoselective Reductive Amination
  • 3.3 Asymmetric Synthesis of the Key Intermediate of Dextromethorphan Catalysed by an Imine Reductase
  • 3.4 Identification of Imine Reductases for Asymmetric Synthesis of 1-Aryl-tetrahydroisoquinolines
  • 3.5 Preparation of Imine Reductases at 15 L Scale and Their Application in Asymmetric Piperazine Synthesis
  • 5.4 Convenient Approach to the Biosynthesis of C2,C6-Disubstituted Purine Nucleosides Using E. coli Purine Nucleoside Phosphorylase and Arsenolysis
  • 5.5 Production of L- and D-Phenylalanine Analogues Using Tailored Phenylalanine Ammonia-Lyases
  • 5.6 Asymmetric Reductive Amination of Ketones Catalysed by Amine Dehydrogenases
  • 5.7 Utilisation of Adenylating Enzymes for the Formation of N-Acyl Amides
  • Chapter 6 Carbon-Carbon Bond Formation or Cleavage
  • 6.1 An Improved Enzymatic Method for the Synthesis of (R)-Phenylacetyl Carbinol

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