Organometallic chemistry in industry : a practical approach /

"Showcases the important role of organometallic chemistry in industrial applications and includes practical examples and case studies This comprehensive book takes a practical approach to how organometallic chemistry is being used in industrial applications. It uniquely offers numerous, real-wo...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Colacot, Thomas (Editor ), Seechurn, Carin C. C. Johansson (Editor ), Grubbs, Robert H. (writer of foreword.)
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Weinheim : Wiley-VCH, [2020]
Temas:
Organometallic chemistry.
Chimie organométallique.
SCIENCE > Chemistry > Organic.
Organometallic chemistry
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Cover
  • Title Page
  • Copyright
  • Contents
  • Foreword
  • Preface
  • Chapter 1 Industrial Milestones in Organometallic Chemistry
  • 1.1 Definition of Organometallic and Metal-Organic Compounds
  • 1.1.1 Applications and Key Reactivity
  • 1.1.1.1 Electronic Applications
  • 1.1.1.2 Polymers
  • 1.1.1.3 Organic Synthesis
  • 1.2 Industrial Process Considerations
  • 1.3 Brief Notes on the Historical Development of Organometallic Chemistry for Organic Synthesis Applications Pertaining to the Contents of this Book
  • 1.3.1 Synthesis of Stoichiometric Organometallic Reagents
  • 1.3.1.1 Conventional Batch Synthesis
  • 1.3.1.2 Organometallics in Flow
  • 1.3.2 Cross-coupling Reactions
  • 1.3.2.1 C-HBond Activation
  • 1.3.2.2 Carbonylation
  • 1.3.2.3 Catalysis in Water
  • Micellar Catalysis
  • 1.3.3 Hydrogenation Reactions
  • 1.3.4 Olefin Formation Reactions
  • 1.3.4.1 Wittig Reaction
  • 1.3.4.2 Metathesis Reactions
  • 1.3.4.3 Dehydrative Decarbonylation
  • 1.3.4.4 Olefins as Starting Materials
  • 1.3.5 Poly- or Oligomerization Processes
  • 1.3.6 Photoredox Catalysis for Organic Synthesis
  • 1.4 Conclusion and Outlook
  • Biography
  • References
  • Chapter 2 Design, Development, and Execution of a Continuous-flow-Enabled API Manufacturing Route
  • 2.1 Continuous-flow-Enabled Synthetic Strategy
  • 2.2 Design and Scale-up of Chan-Lam Coupling
  • 2.2.1 Development of Homogeneous Conditions
  • 2.2.2 Application of a Platform Technology to Aerobic Oxidation
  • 2.2.3 Optimization of Reaction and Workup Parameters
  • 2.2.4 Safety Considerations for Aerobic Oxidation on Scale
  • 2.2.5 Continuous Scale-up and Manufacturing
  • 2.3 Design and Scale-up of a Buchwald-Hartwig Cross-coupling
  • 2.3.1 Initial Screening
  • 2.3.2 Synthesis and Isolation of Pd(dba)DPEPhos Precatalyst
  • 2.3.3 Workup Procedure, Metal Removal, and Crystallization
  • 2.3.4 Scale-up and Manufacturing
  • 2.4 Impurity Control
  • 2.4.1 Solubility and Impurity Spiking Studies
  • 2.5 Conclusions
  • Biography
  • References
  • Chapter 3 Continuous Manufacturing as an Enabling Technology for Low-Temperature Organometallic Chemistry
  • 3.1 Introduction
  • 3.2 Organo-Li and Mg Processes in Flow Mode
  • 3.2.1 Technological Advantages of Flow Technology Compared to Traditional Batch Operation
  • 3.2.2 Temperature Profile of Continuous Flow Reactions
  • 3.2.3 Flash Chemistry: Functional Group Tolerance
  • 3.2.4 Flash Chemistry: Selectivity
  • 3.2.5 Flash Chemistry: Stoichiometry and Chemoselectivity
  • 3.3 Continuous Flow Technology
  • 3.3.1 Clogging as a Major Hurdle in Flow Chemistry
  • 3.3.2 Start-up and Shutdown Operation
  • 3.3.3 Material of Construction
  • 3.3.4 Safety Concept and Emergency Strategies
  • 3.4 Development of a Flow Process
  • 3.4.1 Screening Phase: Feasibility Study
  • 3.4.2 Process Development Phase: Extended Evaluations Including Technical Feasibility
  • 3.5 Literature Examples: Flow Processes on Multi 100 g Scale

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