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Organometallic chemistry in industry : a practical approach /
"Showcases the important role of organometallic chemistry in industrial applications and includes practical examples and case studies This comprehensive book takes a practical approach to how organometallic chemistry is being used in industrial applications. It uniquely offers numerous, real-wo...
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | , , |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Weinheim :
Wiley-VCH,
[2020]
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| Temas: | |
| Acceso en línea: | Texto completo |
MARC
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| 001 | KNOVEL_on1140787329 | ||
| 003 | OCoLC | ||
| 005 | 20231027140348.0 | ||
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| 008 | 200215t20202020gw a ob 001 0 eng d | ||
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| 019 | |a 1141025760 | ||
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| 035 | |a (OCoLC)1140787329 |z (OCoLC)1141025760 | ||
| 050 | 4 | |a QD411 | |
| 082 | 0 | 4 | |a 661/.895 |2 23 |
| 049 | |a UAMI | ||
| 245 | 0 | 0 | |a Organometallic chemistry in industry : |b a practical approach / |c edited by Thomas J. Colacot, Carin C.C. Johansson Seechurn ; with a foreword by Robert H. Grubbs. |
| 264 | 1 | |a Weinheim : |b Wiley-VCH, |c [2020] | |
| 264 | 4 | |c ©2020 | |
| 300 | |a 1 online resource (338 pages) : |b illustrations | ||
| 336 | |a text |b txt |2 rdacontent | ||
| 337 | |a computer |b c |2 rdamedia | ||
| 338 | |a online resource |b cr |2 rdacarrier | ||
| 588 | 0 | |a Print version record. | |
| 505 | 0 | |a Cover -- Title Page -- Copyright -- Contents -- Foreword -- Preface -- Chapter 1 Industrial Milestones in Organometallic Chemistry -- 1.1 Definition of Organometallic and Metal-Organic Compounds -- 1.1.1 Applications and Key Reactivity -- 1.1.1.1 Electronic Applications -- 1.1.1.2 Polymers -- 1.1.1.3 Organic Synthesis -- 1.2 Industrial Process Considerations -- 1.3 Brief Notes on the Historical Development of Organometallic Chemistry for Organic Synthesis Applications Pertaining to the Contents of this Book -- 1.3.1 Synthesis of Stoichiometric Organometallic Reagents | |
| 505 | 8 | |a 1.3.1.1 Conventional Batch Synthesis -- 1.3.1.2 Organometallics in Flow -- 1.3.2 Cross-coupling Reactions -- 1.3.2.1 C-HBond Activation -- 1.3.2.2 Carbonylation -- 1.3.2.3 Catalysis in Water -- Micellar Catalysis -- 1.3.3 Hydrogenation Reactions -- 1.3.4 Olefin Formation Reactions -- 1.3.4.1 Wittig Reaction -- 1.3.4.2 Metathesis Reactions -- 1.3.4.3 Dehydrative Decarbonylation -- 1.3.4.4 Olefins as Starting Materials -- 1.3.5 Poly- or Oligomerization Processes -- 1.3.6 Photoredox Catalysis for Organic Synthesis -- 1.4 Conclusion and Outlook -- Biography -- References | |
| 505 | 8 | |a Chapter 2 Design, Development, and Execution of a Continuous-flow-Enabled API Manufacturing Route -- 2.1 Continuous-flow-Enabled Synthetic Strategy -- 2.2 Design and Scale-up of Chan-Lam Coupling -- 2.2.1 Development of Homogeneous Conditions -- 2.2.2 Application of a Platform Technology to Aerobic Oxidation -- 2.2.3 Optimization of Reaction and Workup Parameters -- 2.2.4 Safety Considerations for Aerobic Oxidation on Scale -- 2.2.5 Continuous Scale-up and Manufacturing -- 2.3 Design and Scale-up of a Buchwald-Hartwig Cross-coupling -- 2.3.1 Initial Screening | |
| 505 | 8 | |a 2.3.2 Synthesis and Isolation of Pd(dba)DPEPhos Precatalyst -- 2.3.3 Workup Procedure, Metal Removal, and Crystallization -- 2.3.4 Scale-up and Manufacturing -- 2.4 Impurity Control -- 2.4.1 Solubility and Impurity Spiking Studies -- 2.5 Conclusions -- Biography -- References -- Chapter 3 Continuous Manufacturing as an Enabling Technology for Low-Temperature Organometallic Chemistry -- 3.1 Introduction -- 3.2 Organo-Li and Mg Processes in Flow Mode -- 3.2.1 Technological Advantages of Flow Technology Compared to Traditional Batch Operation -- 3.2.2 Temperature Profile of Continuous Flow Reactions | |
| 505 | 8 | |a 3.2.3 Flash Chemistry: Functional Group Tolerance -- 3.2.4 Flash Chemistry: Selectivity -- 3.2.5 Flash Chemistry: Stoichiometry and Chemoselectivity -- 3.3 Continuous Flow Technology -- 3.3.1 Clogging as a Major Hurdle in Flow Chemistry -- 3.3.2 Start-up and Shutdown Operation -- 3.3.3 Material of Construction -- 3.3.4 Safety Concept and Emergency Strategies -- 3.4 Development of a Flow Process -- 3.4.1 Screening Phase: Feasibility Study -- 3.4.2 Process Development Phase: Extended Evaluations Including Technical Feasibility -- 3.5 Literature Examples: Flow Processes on Multi 100 g Scale | |
| 500 | |a 3.5.1 Manufacture of Verubecestat (MK-8931) | ||
| 504 | |a Includes bibliographical references and index. | ||
| 520 | |a "Showcases the important role of organometallic chemistry in industrial applications and includes practical examples and case studies This comprehensive book takes a practical approach to how organometallic chemistry is being used in industrial applications. It uniquely offers numerous, real-world examples and case studies that aid working R & D researchers as well as Ph. D. and postdoc students preparing to ace interviews in order to enter the workforce. Edited by two world-leading and established industrial chemists, the book covers flow chemistry (catalytic and non-catalytic organometallic chemistry), various cross-coupling reactions (C-C, C-N, and C-B) in classical batch chemistry, conjugate addition reactions, metathesis, and C-H arylation and achiral hydrogenation reactions. Beginning with an overview of the many industrial milestones within the field over the years, Organometallic Chemistry in Industry: A Practical Approach provides chapters covering: the design, development, and execution of a continuous flow enabled API manufacturing route; continuous manufacturing as an enabling technology for low temperature organometallic chemistry; the development of a nickel-catalyzed enantioselective Mizoroki-Heck coupling; and the development of iron-catalyzed Kumada cross-coupling for the large scale production of Aliskiren intermediates."-- |c Provided by publisher. | ||
| 590 | |a Knovel |b ACADEMIC - Chemistry & Chemical Engineering | ||
| 650 | 0 | |a Organometallic chemistry. | |
| 650 | 6 | |a Chimie organométallique. | |
| 650 | 7 | |a SCIENCE |x Chemistry |x Organic. |2 bisacsh | |
| 650 | 7 | |a Organometallic chemistry |2 fast | |
| 700 | 1 | |a Colacot, Thomas, |e editor. | |
| 700 | 1 | |a Seechurn, Carin C. C. Johansson, |e editor. | |
| 700 | 1 | |a Grubbs, Robert H., |e writer of foreword. | |
| 776 | 0 | 8 | |i Print version: |a Grubbs, Robert H. |t Organometallic Chemistry in Industry : A Practical Approach. |d Newark : John Wiley & Sons, Incorporated, ©2020 |z 9783527345175 |
| 856 | 4 | 0 | |u https://appknovel.uam.elogim.com/kn/resources/kpOCIAPA05/toc |z Texto completo |
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