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How to optimize fluid bed processing technology : part of the expertise in pharmaceutical process technology series /
How to Optimize Fluid Bed Processing Technology: Part of the Expertise in Pharmaceutical Process Technology Series addresses the important components of fluid bed granulation, providing answers to problems that commonly arise and using numerous practical examples and case studies as reference. This...
| Clasificación: | Libro Electrónico |
|---|---|
| Autor principal: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
London :
Academic Press,
2017.
|
| Colección: | Expertise in pharmaceutical process technology series
|
| Temas: | |
| Acceso en línea: | Texto completo |
MARC
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| 100 | 1 | |a Parikh, Dilip M., |d 1945- |e author. | |
| 245 | 1 | 0 | |a How to optimize fluid bed processing technology : |b part of the expertise in pharmaceutical process technology series / |c Dilip M. Parikh. |
| 264 | 1 | |a London : |b Academic Press, |c 2017. | |
| 300 | |a 1 online resource : |b illustrations (some color) | ||
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| 490 | 0 | |a Expertise in pharmaceutical process technology series | |
| 504 | |a Includes bibliographical references and index. | ||
| 588 | 0 | |a Vendor-supplied metadata. | |
| 505 | 0 | |a Front Cover; How to Optimize Fluid Bed Processing Technology; Copyright Page; Dedication; Contents; About the Expertise in Pharmaceutical Process Technology Series; Format; Subject Matter; Target Audience; 1 Introduction; 1.1 Introduction; 1.2 Advantages and Challenges of Fluidized Bed Granulation; 1.2.1 Granulation; 1.2.2 Drying; 1.2.3 Coating; 1.2.4 Challenges; 2 Fluidization Theory; 2.1 How Does Fluidization Take Place?; 2.2 Understanding the Particles; 2.3 Types of Fluid Beds; 2.4 Controlling Gas Velocity; 2.5 Addressing Fluidization Challenges; 2.6 Summary; References. | |
| 505 | 8 | |a 3 Fluid Bed Processor Equipment and Its Functionality3.1 Introduction; 3.2 Questions Before Specifying the Equipment; 3.2.1 Granulating in Fluid Bed; 3.2.2 Drying in Fluid Bed; 3.2.3 Coating in Fluid Bed; 3.3 Fluid Bed Processor Components; 3.3.1 Machine Tower; 3.3.2 Air Handling Unit (AHU); 3.3.3 Fan; 3.3.4 Product Container; 3.3.5 Solution Delivery System; 3.3.6 Utilities; 3.3.7 Process Filters; 3.3.8 Control Panel; 3.4 Summary; 4 Process Development; 4.1 Process Selection; 4.2 Quality by Design; 4.3 Processing in Fluid Bed; 4.3.1 Establishing the Critical Process Parameters. | |
| 505 | 8 | |a 4.4 Risk Assessment and Management4.4.1 Risk Reduction and Control; 4.5 Process Control; 4.6 Case Study; 4.7 Summary; Reference; 5 Granulation; 5.1 Theory; 5.1.1 Process; 5.2 Binders; 5.2.1 How to Select the Proper Binder?; 5.3 Nozzles; 5.3.1 The Different Orientations of the Spray Nozzle; 5.3.2 Nozzle Blockage; 5.4 Process Parameters; 5.5 Challenges in Fluid Bed Granulation; 5.6 Granulation End Point; 5.6.1 Off-Line Methods; 5.6.2 Near Infrared (NIR); 5.6.3 Focused Beam Reflectance Measurement (FBRM); 5.6.4 Spatial Filtering Velocimetry (Parsum); 5.6.5 Imaging Methods. | |
| 505 | 8 | |a 5.7 Granulation Characterization5.8 Summary; References; 6 Drying; 6.1 Theory; 6.2 Drying Granulated Product; 6.2.1 Drying Challenges; 6.2.1.1 Loading the Wet Granulated Product in the Fluid Bed Bowl; 6.2.1.2 Effect of Particle Size on Drying End Point; 6.2.1.3 Minimizing Granule Breakage; 6.2.1.4 Fluidizing Heavy/Cohesive Product; 6.2.1.5 Minimizing Product Segregation; 6.2.1.6 Avoiding Uneven Drying of the Granulation; 6.2.1.7 Drying Nonaqueous Granulation; 6.2.1.8 Minimizing the Drying Time to Increase Optimizing the Drying Process; 6.2.1.9 Increasing Yield After Drying. | |
| 505 | 8 | |a 6.2.1.10 Determination of End Point6.2.1.10.1 Off-Line Methods; 6.2.1.10.2 Other Off-Line Methods; 6.2.1.10.3 On-Line/At-Line Methods; Near-Infrared (NIR); Effusivity; 6.3 Summary; References; 7 Coating; 7.1 Introduction; 7.2 Top-Spray Coating; 7.2.1 Hot Melt Coating in Fluid Bed; 7.3 Wurster Coating; 7.3.1 Operating a Wurster Coater; 7.4 Other Coating Modules; 7.4.1 Precision Coater; 7.4.2 FlexStream System for Coating; 7.4.3 Rotary or Tangential Fluid Bed Coating; 7.5 Dry Powder Coating; 7.6 Problems in Coating in Fluid Bed; 7.7 Case Studies; 7.7.1 Case Study 1; 7.7.2 Case Study 2. | |
| 520 | |a How to Optimize Fluid Bed Processing Technology: Part of the Expertise in Pharmaceutical Process Technology Series addresses the important components of fluid bed granulation, providing answers to problems that commonly arise and using numerous practical examples and case studies as reference. This book covers the theoretical concepts involved in fluidization, also providing a description of the choice and functionality of equipment. Additional chapters feature key aspects of the technology, including formulation requirements, process variables, process scale-up, troubleshooting, new development, safety, and process evaluation. Given its discussion of theoretical principles and practical solutions, this is a go-to resource for all those scientists and new researchers working with fluid bed granulation as a unit operation. | ||
| 590 | |a Knovel |b ACADEMIC - Pharmaceuticals, Cosmetics & Toiletries | ||
| 590 | |a Knovel |b ACADEMIC - Chemistry & Chemical Engineering | ||
| 650 | 0 | |a Fluidization. | |
| 650 | 0 | |a Granulation. | |
| 650 | 6 | |a Fluidisation. | |
| 650 | 6 | |a Granulation. | |
| 650 | 7 | |a SCIENCE |x Chemistry |x Industrial & Technical. |2 bisacsh | |
| 650 | 7 | |a TECHNOLOGY & ENGINEERING |x Chemical & Biochemical. |2 bisacsh | |
| 650 | 7 | |a Fluidization |2 fast | |
| 650 | 7 | |a Granulation |2 fast | |
| 776 | 0 | 8 | |i Print version: |a Parikh, Dilip M., 1945- |t How to optimize fluid bed processing technology. |d London : Academic Press, 2017 |z 0128047275 |z 9780128047279 |w (OCoLC)959885625 |
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