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KNOVEL_ocn922323918 |
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OCoLC |
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20231027140348.0 |
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m o d |
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cr cnu|||unuuu |
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150928s2016 ne ob 001 0 eng d |
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|z 2015939545
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|b eng
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|d OCLCO
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|d UIU
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|a 922918604
|a 929521751
|a 932328797
|a 951666431
|a 1066557439
|a 1235840032
|a 1340052637
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|a 9780081001141
|q (electronic bk.)
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|a 0081001142
|q (electronic bk.)
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|z 9780081000946
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|z 0081000944
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|b 45152960X
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|a (OCoLC)922323918
|z (OCoLC)922918604
|z (OCoLC)929521751
|z (OCoLC)932328797
|z (OCoLC)951666431
|z (OCoLC)1066557439
|z (OCoLC)1235840032
|z (OCoLC)1340052637
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| 050 |
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4 |
|a RM301.25
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| 060 |
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4 |
|a 2015 L-371
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| 060 |
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4 |
|a QV 38
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| 072 |
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|a MED
|x 071000
|2 bisacsh
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0 |
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|a 615/.1901
|2 23
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| 049 |
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|a UAMI
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| 245 |
0 |
0 |
|a Concepts and models for drug permeability studies :
|b cell and tissue based In vitro culture models /
|c edited by Bruno Sarmento.
|
| 264 |
|
1 |
|a Amsterdam :
|b Elsevier Ltd.,
|c 2016.
|
| 264 |
|
4 |
|c ©2016
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| 300 |
|
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|a 1 online resource
|
| 336 |
|
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|a text
|b txt
|2 rdacontent
|
| 337 |
|
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|a computer
|b c
|2 rdamedia
|
| 338 |
|
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|a online resource
|b cr
|2 rdacarrier
|
| 490 |
1 |
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|a Woodhead Publishing series in biomedicine ;
|v number 79
|
| 588 |
0 |
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|a Online resource; title from PDF title page (EBSCO, viewed September 30, 2015).
|
| 504 |
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|a Includes bibliographical references and index.
|
| 505 |
0 |
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|a Front Cover; Related titles; Concepts and Models for Drug Permeability Studies; Copyright; Contents; List of contributors; List of figures; List of tables; 1 -- Introduction; 1.1 Introduction; References; 2 -- Importance and applications of cell- and tissue-based in vitro models for drug permeability screening in early stages o ... ; 2.1 Introduction; 2.2 General considerations; 2.3 Drug transport; 2.3.1 Transport mechanisms; 2.4 Permeability-absorption models; 2.4.1 Physicochemical methods; 2.4.1.1 Physicochemical factors; 2.4.1.2 Immobilized artificial membrane chromatography
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| 505 |
8 |
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|a 2.4.1.3 Parallel artificial membrane permeability assay2.4.2 In vitro cell and tissue methods; 2.4.2.1 Cell-based methods; 2.4.2.2 Tissue-based methods; Diffusion chambers; Franz cells; Everted sacs; Isolated membrane vesicles; 2.5 Methods for permeability calculation; 2.6 Standardization of protocols for in vitro methods; 2.7 The "three Rs" principle; 2.8 Biosecurity systems; References; 3.1 -- Cell-based in vitro models for buccal permeability studies; 3.1.1 Introduction; 3.1.2 Physiology of the buccal mucosa; 3.1.3 Different in vitro models; 3.1.3.1 Hamster cheek pouch cells
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| 505 |
8 |
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|a 3.1.3.2 TR146 cell line3.1.3.2.1 Protocol; Cell culture conditions; Permeability studies; 3.1.3.3 Human oral keratinocytes; 3.1.3.3.1 Protocol; Oral keratinocyte culture conditions; Culturing on dead de-epidermized dermis (DDED); Permeability studies; 3.1.3.4 MatTek EpiOral™; 3.1.3.4.1 Protocol; Cell culture conditions; Permeability studies; 3.1.4 Conclusions; References; 3.2 -- Cell-based in vitro models for gastric permeability studies; 3.2.1 The stomach as a natural barrier to absorption; 3.2.2 Gastric drug delivery; 3.2.2.1 Molecular absorption in the stomach
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| 505 |
8 |
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|a 3.2.2.2 Physicochemical factors mediating stomach absorptive permeability3.2.3 Cellularized models of gastric permeability; 3.2.3.1 Protocol for establishing cellularized artificial models of the gastric wall; 3.2.4 Conclusions; Acknowledgments; References; 3.3 -- Cell-based in vitro models for intestinal permeability studies; 3.3.1 Anatomy and physiology of human small intestine; 3.3.1.1 Stromal-epithelial cross-talk; 3.3.2 Mechanisms of transport; 3.3.3 Intestinal barriers; 3.3.4 Intestinal in vitro models; 3.3.4.1 Caco-2 model; 3.3.4.1.1 Accelerated Caco-2 models
|
| 505 |
8 |
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|a 3.3.4.1.2 Alternatives to the Caco-2 model3.3.4.2 Caco-2/HT29-MTX model; 3.3.4.3 Caco-2/Raji B model; 3.3.4.4 Caco-2/HT29-MTX/Raji B; 3.3.4.5 Novel 3D in vitro models; 3.3.5 Validation studies; 3.3.6 Conclusions; References; 3.4 -- Cell-based in vitro models for nasal permeability studies; 3.4.1 Introduction; 3.4.2 Nasal primary cell culture models; 3.4.2.1 Sampling approaches and procedures; 3.4.2.2 HNE cell preparation and culture initiation; 3.4.3 Immortalized nasal cell lines; 3.4.3.1 RMPI 2650 cell line; 3.4.3.2 BT cell line; 3.4.3.3 Human lung carcinoma cell line
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| 590 |
|
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|a Knovel
|b ACADEMIC - Pharmaceuticals, Cosmetics & Toiletries
|
| 650 |
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0 |
|a Drugs
|x Testing.
|
| 650 |
|
0 |
|a Drugs
|x Physiological transport
|x Research
|x Methodology.
|
| 650 |
|
0 |
|a Epithelial cells.
|
| 650 |
|
0 |
|a Cell culture.
|
| 650 |
|
0 |
|a Permeability.
|
| 650 |
|
0 |
|a Pharmacokinetics.
|
| 650 |
|
0 |
|a Biological models.
|
| 650 |
1 |
2 |
|a Permeability
|
| 650 |
1 |
2 |
|a Pharmacokinetics
|
| 650 |
|
2 |
|a Clinical Trials as Topic
|
| 650 |
|
2 |
|a Epithelial Cells
|
| 650 |
|
2 |
|a Cells, Cultured
|
| 650 |
2 |
2 |
|a Pharmaceutical Preparations
|x metabolism
|
| 650 |
2 |
2 |
|a Models, Biological
|
| 650 |
2 |
2 |
|a Tissue Culture Techniques
|
| 650 |
2 |
2 |
|a Cell Culture Techniques
|
| 650 |
|
6 |
|a Médicaments
|x Essais cliniques.
|
| 650 |
|
6 |
|a Médicaments
|x Transport physiologique
|x Recherche
|x Méthodologie.
|
| 650 |
|
6 |
|a Cellules épithéliales.
|
| 650 |
|
6 |
|a Cellules
|x Culture.
|
| 650 |
|
6 |
|a Perméabilité.
|
| 650 |
|
6 |
|a Pharmacocinétique.
|
| 650 |
|
6 |
|a Modèles biologiques.
|
| 650 |
|
6 |
|a Cellules
|x Culture
|x Technique.
|
| 650 |
|
7 |
|a MEDICAL
|x Pharmacology.
|2 bisacsh
|
| 650 |
|
7 |
|a Pharmacokinetics
|2 fast
|
| 650 |
|
7 |
|a Permeability
|2 fast
|
| 650 |
|
7 |
|a Biological models
|2 fast
|
| 650 |
|
7 |
|a Cell culture
|2 fast
|
| 650 |
|
7 |
|a Drugs
|x Testing
|2 fast
|
| 650 |
|
7 |
|a Epithelial cells
|2 fast
|
| 700 |
1 |
|
|a Sarmento, Bruno,
|e editor.
|
| 776 |
0 |
8 |
|i Print version:
|z 9780081000946
|z 0081000944
|w (OCoLC)911073450
|
| 830 |
|
0 |
|a Woodhead Publishing series in biomedicine ;
|v no. 79.
|
| 856 |
4 |
0 |
|u https://appknovel.uam.elogim.com/kn/resources/kpCMDPSCTG/toc
|z Texto completo
|
| 938 |
|
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|a Coutts Information Services
|b COUT
|n 32782143
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| 938 |
|
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|a ProQuest Ebook Central
|b EBLB
|n EBL4003877
|
| 938 |
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|
|a EBSCOhost
|b EBSC
|n 1072124
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| 938 |
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|a ProQuest MyiLibrary Digital eBook Collection
|b IDEB
|n cis32782143
|
| 938 |
|
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|a YBP Library Services
|b YANK
|n 12625025
|
| 994 |
|
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|a 92
|b IZTAP
|
