Translational medicine and drug discovery /

"This book, edited by two leaders known for driving innovation in the field, focuses on the new discipline of translational medicine as it pertains to drug discovery and development within the pharmaceutical and biotechnology industries. Translational medicine seeks to translate biological and...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Littman, Bruce H., 1944- (Editor ), Krishna, Rajesh (Editor )
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Cambridge : Cambridge University Press, 2011.
Temas:
Drug development.
Molecular pharmacology.
Translational Research, Biomedical > methods
Drug Discovery
Médicaments > Développement.
Pharmacologie moléculaire.
MEDICAL > Drug Guides.
MEDICAL > Nursing > Pharmacology.
MEDICAL > Pharmacology.
MEDICAL > Pharmacy.
Drug development
Molecular pharmacology
Acceso en línea:Texto completo
Tabla de Contenidos:
  • SECTION I: Translational Medicine: History, Principles, and Application in Drug Development
  • 1. Translational Medicine: Definition, History, and Strategies / Bruce H. Littman
  • 2. Translational Medicine and Its Impact on Diabetes Drug Development / Roberto A. Calle and Ann E. Taylor
  • 3. Challenges in Atherosclerosis / John S. Millar
  • 4. Obesity: New Mechanisms and Translational Paradigms / Gregory Gaich and David E. Moller
  • 5. Bone Disorders: Translational Medicine Case Studies / S. Aubrey Stoch
  • 6. Case Studies in Neuroscience: Unique Challenges and Examples Gerard / J. Marek
  • 7. Translational Medicine in Oncology / Dominic G. Spinella.
  • SECTION II: Biomarkers and Public-Private Partnerships
  • 8. Biomarker Validation and Application in Early Drug Development: Idea to Proof of Concept / Pfizer Global Research and Development
  • 9. Imaging Biomarkers in Drug Development: Case Studies / Johannes T. Tauscher and Adam J. Schwarz
  • 10. European New Safe and Innovative Medicines Initiatives: History and Progress (through December 2009) / Ole J. Bjerrum and Hans H. Linden
  • 11. Critical Path Institute and the Predictive Safety Testing Consortium / Elizabeth Gribble Walker
  • 12. The Biomarkers Consortium: Facilitating the Development and Qualification of Novel Biomarkers Through a Precompetitive Public-Private Partnership / David Wholley and David B. Lee.
  • SECTION III: Future Directions
  • 13. Improving the Quality and Productivity of Pharmacometric Modeling and Simulation Activities: the Foundation for Model-Based Drug Development / Thaddeus H. Grasela, Jill Fiedler-Kelly, and Robert Slusser
  • 14. Embracing Change: a Pharmaceutical Industry Guide to the 21st Century / Mervyn Turner.

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