Potential impact of individual genetic susceptibility and previous radiation exposure on radiation risk for astronauts /

Detalles Bibliográficos
Clasificación:Libro Electrónico
Autor Corporativo: National Council on Radiation Protection and Measurements
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Bethesda, Maryland : National Council on Radiation Protection and Measurements, ©2011.
Colección:NCRP report ; no. 167.
Temas:
Radiation injuries > Genetic aspects.
Astronauts > Health risk assessment.
Space flight > Health aspects.
Risk assessment.
Radiation Injuries > etiology
Astronauts
Environmental Exposure > adverse effects
Genetic Predisposition to Disease
Risk Assessment
Space Flight
Mal des rayons > Aspect génétique.
Astronautes > Risques pour la santé > Évaluation.
Évaluation du risque.
Vol spatial.
risk assessment.
MEDICAL > Infectious Diseases.
HEALTH & FITNESS > Diseases > Contagious.
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Cover
  • Preface
  • Contents
  • Executive Summary
  • 1. Introduction
  • 1.1 Purpose of the Report
  • 1.2 Contents of the Report
  • 1.2.1 Introduction
  • 1.2.2 Radiation Exposures Received Over Lifetimes of Astronauts
  • 1.2.3 Biology Pertinent to Variations in Individual Susceptibility with Respect to Radiation Risks for Astronauts
  • 1.2.4 Predicting Cancer Risks from Previous Radiation or Chemotherapy Treatments
  • 1.2.5 Basis for Considering Medical Treatment, Disease, and Genetic Background in the NASA Occupational Radiation Protection Program
  • 1.2.6 Regulatory and Statutory Issues1.2.7 Ethical Issues of Radiation Exposure, Genetic Background, and Astronaut Selection for Space Missions
  • 1.2.8 Background Issues, Conclusions, and Recommendations
  • 2. Radiation Exposures Received Over Lifetimes of Astronauts
  • 2.1 Radiation Protection Quantities
  • 2.1.1 Absorbed Dose
  • 2.1.2 Categories of Radiation-Induced Biological Effects
  • 2.1.3 Radiation Protection Quantities for Deterministic Effects
  • 2.1.4 Radiation Protection Quantities for Stochastic Effects
  • 2.2 Sources of Exposure to Ionizing Radiation
  • 2.2.1 Radiation Exposures Received by the U.S. Population2.2.2 Medical Exposures
  • 2.2.3 Space Radiation Exposures During Previous Space Missions
  • 2.2.4 Radiation Exposures During Jet Aircraft Flights
  • 2.3 Key Issues
  • 3. Biology Pertinent to Variations in Individual Susceptibility with Respect to Radiation Risks for Astronauts
  • 3.1 Overview
  • 3.2 Average Risks for Radiation-Induced Diseases of Concern for Astronauts
  • 3.2.1 Cancer Risk
  • 3.2.2 Heritable Risk
  • 3.2.3 Embryo and Fetal Risk
  • 3.2.4 Other Risks Associated with Radiation Exposure
  • 3.3 Evidence of Variation in Radiation Sensitivity and Susceptibility to Effects of Principal Concern3.3.1 Evidence of Genetic Variation in Radiation Sensitivity from Cellular and Molecular Research
  • 3.3.2 Evidence for Variation in Radiation Sensitivity from Animal Studies
  • 3.3.3 Evidence of Variation in Radiation Sensitivity from Human Studies
  • 3.3.4 Genetic Sources of Variation in Cancer Susceptibility
  • 3.3.5 Impact of Genetic Variation on Radiation Risk
  • 3.3.6 Congenital Sources of Variation in Cancer Susceptibility
  • 3.3.7 Special Considerations for Astronauts3.3.8 Key Issues
  • 4. Predicting Cancer Risks from Previous Radiation or Chemotherapy Treatments
  • 4.1 Introduction
  • 4.2 Second Cancers After Radiation Therapy
  • 4.2.1 Carcinogenic Effects of Radiation
  • 4.2.2 Factors Affecting Risk of Second Malignancy
  • 4.3 Risk of Radiation-Induced Malignancies
  • 4.3.1 Radiation-Induced Leukemia
  • 4.3.2 Radiation-Induced Solid Tumors
  • 4.4 Characteristics of Medical Radiation Exposures
  • 4.4.1 Radiation Dose
  • 4.4.2 Radiation Treatment Planning and Delivery

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