Evaluation of the linear-nonthreshold dose-response model for ionizing radiation.

Annotation

Detalles Bibliográficos
Clasificación:Libro Electrónico
Autor Corporativo: National Council on Radiation Protection and Measurements
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Bethesda, Md. : National Council on Radiation Protection and Measurements, ©2001.
Colección:NCRP report ; no. 136.
Temas:
Radiation > Toxicology.
Low-level radiation > Dose-response relationship.
Dose-Response Relationship, Radiation
Radiation, Ionizing > radiation effects
Rayonnement > Toxicologie.
Rayonnement > Relations dose-effet.
Low-level radiation > Dose-response relationship
Radiation > Toxicology
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Cover Page
  • Preface
  • Contents
  • 1. Executive Summary
  • 2. Introduction
  • 3. Biophysical
  • 3.1 Energy Deposition and Its Relevance to Questions of Low-Dose Response
  • 3.1.1 Track Structure
  • 3.1.2 Quantitative Characterization of Energy Deposition in Small Sites
  • 3.1.3 Definition of Low Dose, Corresponding to an Average of One Energy Deposition Event per Target
  • 3.2 Implications of Energy-Deposition Patterns for Independent Cellular Effects at Low Doses
  • 3.3 Implications of Energy-Deposition Patterns for Carcinogenic Effects of Radiation
  • 3.3.1 Evidence Regarding the Clonality of Tumors3.3.2 Relationship Between Initially-Damaged Cells and Tumorigenic Cells
  • 3.4 Conclusions
  • 3.5 Research Needs
  • 4. Deoxyribonucleic Acid Repair and Processing after Low Doses and Low-Dose Rates of Ionizing Radiation
  • 4.1 Ionizing Radiation-Induced DNA Lesions and Their Repair
  • 4.1.1 Single-Strand Breaks (Including Deoxyribose Damage)
  • 4.1.2 Base Damage and Loss
  • 4.1.3 DNA-Protein Cross-Links
  • 4.1.4 Double-Strand Breaks
  • 4.1.5 Multiply-Damaged Sites
  • 4.1.6 Mismatch Repair
  • 4.1.7 Effects of Linear-Energy Transfer4.1.8 Spontaneous DNA Damage
  • 4.2 Cell-Cycle Checkpoints
  • 4.3 Programmed Cell Death (Apoptosis)
  • 4.4 Impact of Cell-Cycle Checkpoints and Apoptosis on the Dose Response for DNA Repair at Low-Dose Rates
  • 4.5 The Adaptive Response
  • 4.6 Summary
  • 4.7 Research Needs
  • 5. Mutagenesis
  • 5.1 Introduction
  • 5.2 Potential Mechanisms of Mutagenesis
  • 5.2.1 Replication Errors
  • 5.2.2 Mutations Arising During Repair
  • 5.3 Dose-Response Studies with Low Linear-Energy Transfer Radiation
  • 5.3.1 Human in Vivo
  • 5.3.2 Animal in Vivo5.3.3 Mammalian Cells in Vitro
  • 5.4 Dose-Response Studies with High Linear-Energy Transfer Radiation
  • 5.5 Summary
  • 5.6 Research Needs
  • 6. Chromosome Aberrations Induced by Low Doses and Low-Dose Rates of Ionizing Radiation
  • 6.1 Misrepair, Misreplication, and Chromosome Aberration Formation
  • 6.1.1 Chromosome-Type Aberrations
  • 6.1.2 Chromatid-Type Aberrations
  • 6.1.3 Mechanisms of Formation of Chromosome Aberrations
  • 6.1.4 Dose-Response Curves: Acute and Chronic Exposures
  • 6.2 Distribution of Aberrations Within and Among Cells
  • 6.2.1 Intercellular Distributions of Chromosome Aberrations6.2.2 Inter- and Intrachromosomal Distribution of Chromosome Aberrations
  • 6.3 Uncertainties in Shapes of Dose-Response Curves at Low Doses
  • 6.3.1 Nonlinear and Threshold Responses
  • 6.3.2 Effect of Adaptive Response
  • 6.3.3 Efficiency of DNA Repair
  • 6.3.4 Inducibility of DNA Repair and Cell-Cycle Checkpoints
  • 6.3.5 Genomic Instability
  • 6.4 Association Between Chromosomal Changes and Cancer
  • 6.5 Biological Dosimetry for Chromosome Aberrations
  • 6.5.1 Acute Exposures
  • 6.5.2 Chronic Exposures

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