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Evaluation of the linear-nonthreshold dose-response model for ionizing radiation.
Annotation
| Clasificación: | Libro Electrónico |
|---|---|
| Autor Corporativo: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Bethesda, Md. :
National Council on Radiation Protection and Measurements,
©2001.
|
| Colección: | NCRP report ;
no. 136. |
| Temas: | |
| Acceso en línea: | Texto completo |
MARC
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| 245 | 0 | 0 | |a Evaluation of the linear-nonthreshold dose-response model for ionizing radiation. |
| 260 | |a Bethesda, Md. : |b National Council on Radiation Protection and Measurements, |c ©2001. | ||
| 300 | |a 1 online resource (ix, 287 pages) : |b illustrations : digital, HTML and PDF files | ||
| 336 | |a text |b txt |2 rdacontent | ||
| 337 | |a computer |b c |2 rdamedia | ||
| 338 | |a online resource |b cr |2 rdacarrier | ||
| 490 | 1 | |a NCRP report ; |v no. 136 | |
| 500 | |a "Issued June 4, 2001." | ||
| 500 | |a "Recommendations of the National Council on Radiation Protection and Measurements." | ||
| 504 | |a Includes bibliographical references (pages 212-263) and index. | ||
| 588 | 0 | |a Print version record. | |
| 520 | 8 | |a Annotation |b New experimental and epidemiological findings include growing evidence of adaptive responses to small doses of radiation that may enhance the capacity of cells to withstand the effects of further radiation exposure, and new evidence concerning the possible nature of neoplastic initiation. Therefore, a committee of the National Council on Radiation Protection and Measurements reassesses the weight of scientific evidence for and against the linear-threshold dose-response model for determining safe levels of exposure to ionizing radiation. The report also considers associated policy implications. It finds no reason for rejecting the model. Annotation c. Book News, Inc., Portland, OR (booknews.com). | |
| 505 | 0 | |a Cover Page -- Preface -- Contents -- 1. Executive Summary -- 2. Introduction -- 3. Biophysical -- 3.1 Energy Deposition and Its Relevance to Questions of Low-Dose Response -- 3.1.1 Track Structure -- 3.1.2 Quantitative Characterization of Energy Deposition in Small Sites -- 3.1.3 Definition of Low Dose, Corresponding to an Average of One Energy Deposition Event per Target -- 3.2 Implications of Energy-Deposition Patterns for Independent Cellular Effects at Low Doses -- 3.3 Implications of Energy-Deposition Patterns for Carcinogenic Effects of Radiation | |
| 505 | 8 | |a 3.3.1 Evidence Regarding the Clonality of Tumors3.3.2 Relationship Between Initially-Damaged Cells and Tumorigenic Cells -- 3.4 Conclusions -- 3.5 Research Needs -- 4. Deoxyribonucleic Acid Repair and Processing after Low Doses and Low-Dose Rates of Ionizing Radiation -- 4.1 Ionizing Radiation-Induced DNA Lesions and Their Repair -- 4.1.1 Single-Strand Breaks (Including Deoxyribose Damage) -- 4.1.2 Base Damage and Loss -- 4.1.3 DNA-Protein Cross-Links -- 4.1.4 Double-Strand Breaks -- 4.1.5 Multiply-Damaged Sites -- 4.1.6 Mismatch Repair | |
| 505 | 8 | |a 4.1.7 Effects of Linear-Energy Transfer4.1.8 Spontaneous DNA Damage -- 4.2 Cell-Cycle Checkpoints -- 4.3 Programmed Cell Death (Apoptosis) -- 4.4 Impact of Cell-Cycle Checkpoints and Apoptosis on the Dose Response for DNA Repair at Low-Dose Rates -- 4.5 The Adaptive Response -- 4.6 Summary -- 4.7 Research Needs -- 5. Mutagenesis -- 5.1 Introduction -- 5.2 Potential Mechanisms of Mutagenesis -- 5.2.1 Replication Errors -- 5.2.2 Mutations Arising During Repair -- 5.3 Dose-Response Studies with Low Linear-Energy Transfer Radiation -- 5.3.1 Human in Vivo | |
| 505 | 8 | |a 5.3.2 Animal in Vivo5.3.3 Mammalian Cells in Vitro -- 5.4 Dose-Response Studies with High Linear-Energy Transfer Radiation -- 5.5 Summary -- 5.6 Research Needs -- 6. Chromosome Aberrations Induced by Low Doses and Low-Dose Rates of Ionizing Radiation -- 6.1 Misrepair, Misreplication, and Chromosome Aberration Formation -- 6.1.1 Chromosome-Type Aberrations -- 6.1.2 Chromatid-Type Aberrations -- 6.1.3 Mechanisms of Formation of Chromosome Aberrations -- 6.1.4 Dose-Response Curves: Acute and Chronic Exposures -- 6.2 Distribution of Aberrations Within and Among Cells | |
| 505 | 8 | |a 6.2.1 Intercellular Distributions of Chromosome Aberrations6.2.2 Inter- and Intrachromosomal Distribution of Chromosome Aberrations -- 6.3 Uncertainties in Shapes of Dose-Response Curves at Low Doses -- 6.3.1 Nonlinear and Threshold Responses -- 6.3.2 Effect of Adaptive Response -- 6.3.3 Efficiency of DNA Repair -- 6.3.4 Inducibility of DNA Repair and Cell-Cycle Checkpoints -- 6.3.5 Genomic Instability -- 6.4 Association Between Chromosomal Changes and Cancer -- 6.5 Biological Dosimetry for Chromosome Aberrations -- 6.5.1 Acute Exposures -- 6.5.2 Chronic Exposures | |
| 546 | |a English. | ||
| 590 | |a Knovel |b ACADEMIC - Safety & Industrial Hygiene | ||
| 650 | 0 | |a Radiation |x Toxicology. | |
| 650 | 0 | |a Low-level radiation |x Dose-response relationship. | |
| 650 | 1 | 2 | |a Dose-Response Relationship, Radiation |
| 650 | 1 | 2 | |a Radiation, Ionizing |x radiation effects |
| 650 | 6 | |a Rayonnement |x Toxicologie. | |
| 650 | 6 | |a Rayonnement |x Relations dose-effet. | |
| 650 | 7 | |a Low-level radiation |x Dose-response relationship |2 fast | |
| 650 | 7 | |a Radiation |x Toxicology |2 fast | |
| 710 | 2 | |a National Council on Radiation Protection and Measurements. | |
| 776 | 0 | 8 | |i Print version: |t Evaluation of the linear-nonthreshold dose-response model for ionizing radiation. |d Bethesda, Md. : National Council on Radiation Protection and Measurements, ©2001 |z 092960069X |w (OCoLC)46872314 |
| 830 | 0 | |a NCRP report ; |v no. 136. | |
| 856 | 4 | 0 | |u https://appknovel.uam.elogim.com/kn/resources/kpELNDRMI2/toc |z Texto completo |
| 938 | |a EBL - Ebook Library |b EBLB |n EBL3382333 | ||
| 938 | |a ebrary |b EBRY |n ebr10233488 | ||
| 938 | |a Internet Archive |b INAR |n evaluationofline00nati | ||
| 994 | |a 92 |b IZTAP | ||