Extrapolation of radiation-induced cancer risks from nonhuman experimental systems to humans.

Detalles Bibliográficos
Clasificación:Libro Electrónico
Autor Corporativo: National Council on Radiation Protection and Measurements
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Bethesda, MD : National Council on Radiation Protection and Measurements, ©2005.
Colección:NCRP report ; no. 150.
Temas:
Radiation carcinogenesis.
Radiation > Toxicology.
Animal models in research.
Carcinogenicity testing.
Diseases > Animal models.
Neoplasms, Radiation-Induced
Carcinogenicity Tests
Disease Models, Animal
Neoplasms, Experimental > chemically induced
Tumeurs dues aux radiations.
Rayonnement > Toxicologie.
Modèles animaux dans la recherche.
Cancérogénicité.
Maladies > Modèles animaux.
MEDICAL > Oncology.
HEALTH & FITNESS > Diseases > Cancer.
Diseases > Animal models
Carcinogenicity testing
Animal models in research
Radiation carcinogenesis
Radiation > Toxicology
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Cover
  • Preface
  • Contents
  • 1. Executive Summary and Recommendations
  • 1.1 Why Is Extrapolation Still Required?
  • 1.2 Summary of Findings
  • 1.2.1 Historical Aspects
  • 1.2.2 Neoplastic Disease
  • 1.2.3 Somatic Genetic Damage at Molecular and Cellular Levels
  • 1.2.4 Extrapolation Models and Methods
  • 1.3 Conclusions
  • 1.4 Recommendations
  • 2. Introduction
  • 3. History of Extrapolation: Nonhuman Experimental Systems to Humans
  • 3.1 Introduction
  • 3.2 Lessons Learned from Genetic Risks
  • 3.2.1 Methods of Estimation
  • 3.2.2 Discussion of Methods of Estimating Genetic Risk3.2.3 Role of Genetics in the Estimation of Somatic Risks
  • 3.3 Somatic Risks
  • 4. Tissue and Organ Differences Among Species with Emphasis on the Cells of Origin of Cancers
  • 4.1 Introduction
  • 4.2 Hematopoietic System
  • 4.2.1 Introduction: Leukemias and Lymphomas
  • 4.2.2 Comparison of Radiation-Induced Leukemias Among Species
  • 4.2.3 Pathology and Dose-Response Relationships
  • 4.2.4 Comparison of Hematopoietic Systems
  • 4.2.5 Target Cells
  • ""4.2.6 Comparison of Cytogenetic Processes: Common or Species-Specific Patterns""""4.2.7 Leukemogenesis Resulting from Gene Rearrangements""; ""4.2.8 Secondary Cytogenetic Lesions Associated with Leukemia Promotion and Progression""; ""4.2.9 Hematopoietic Cell Origins of the Putative “Criticalâ€? Genic Lesions and the Nature of Induced Genic Dysfunctions""; ""4.2.10 Cooperating Oncogenes in Lymphoid Neoplasias""; ""4.2.11 Cooperating Oncogenes in Myeloid Neoplasias""; ""4.2.12 Hematopoeitic Microenvironment""; ""4.2.13 Summary""; ""4.3 Lung""; ""4.3.1 Introduction""
  • 4.3.2 Adenocarcinoma4.3.3 Squamous-Cell Carcinoma
  • 4.3.4 Small-Cell Lung Carcinoma
  • 4.3.5 Large-Cell Carcinoma
  • 4.3.6 Summary
  • 4.4 Breast
  • 4.4.1 Histogenesis of Mammary Glands and Mammary Cancer
  • 4.4.2 Hormones and Mammary Carcinogenesis
  • 4.4.3 Cellular Origins of Mammary Cancer
  • 4.4.4 Summary
  • 4.5 Thyroid
  • 4.5.1 General Background
  • 4.5.2 Histogenesis of the Thyroid Gland and Thyroid Cancer
  • 4.5.3 Thyroid Function and its Control
  • 4.5.4 Cellular Economy of the Thyroid Gland and the Origin of Cancer
  • 4.5.5 Summary
  • 4.6 Skin
  • 4.6.1 Introduction4.6.2 Epidermal Cancers
  • 4.6.3 Melanoma
  • 4.6.4 Tumors of the Dermis
  • 4.6.5 Mechanisms of Epidermal Carcinogenesis
  • 4.6.6 Importance of Interactions
  • 4.6.7 Summary
  • 4.7 Gastrointestinal Tract
  • 4.7.1 Introduction
  • 4.7.2 Stomach
  • 4.7.3 Small Intestine
  • 4.7.4 Colorectal Tumors
  • 4.7.5 Summary
  • 4.8 Bone
  • 4.8.1 Humans
  • 4.8.2 Mice
  • 4.8.3 Rats
  • 4.8.4 Dogs
  • 4.8.5 Summary
  • 5. Radiation Effects at the Molecular and Cellular Levels
  • 5.1 Introduction

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