Extrapolation of radiation-induced cancer risks from nonhuman experimental systems to humans.

Detalles Bibliográficos
Clasificación:Libro Electrónico
Autor Corporativo: National Council on Radiation Protection and Measurements
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Bethesda, MD : National Council on Radiation Protection and Measurements, ©2005.
Colección:NCRP report ; no. 150.
Temas:
Radiation carcinogenesis.
Radiation > Toxicology.
Animal models in research.
Carcinogenicity testing.
Diseases > Animal models.
Neoplasms, Radiation-Induced
Carcinogenicity Tests
Disease Models, Animal
Neoplasms, Experimental > chemically induced
Tumeurs dues aux radiations.
Rayonnement > Toxicologie.
Modèles animaux dans la recherche.
Cancérogénicité.
Maladies > Modèles animaux.
MEDICAL > Oncology.
HEALTH & FITNESS > Diseases > Cancer.
Diseases > Animal models
Carcinogenicity testing
Animal models in research
Radiation carcinogenesis
Radiation > Toxicology
Acceso en línea:Texto completo

MARC

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245 0 0 |a Extrapolation of radiation-induced cancer risks from nonhuman experimental systems to humans. 
260 |a Bethesda, MD :  |b National Council on Radiation Protection and Measurements,  |c ©2005. 
300 |a 1 online resource (xii, 267 pages) :  |b illustrations 
336 |a text  |b txt  |2 rdacontent 
337 |a computer  |b c  |2 rdamedia 
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490 1 |a NCRP report ;  |v no. 150 
500 |a "Recommendations of the National Council on Radiation Protection and Measurements." 
500 |a "Issued November 2005." 
504 |a Includes bibliographical references (pages 194-241) and index. 
588 0 |a Print version record. 
506 |3 Use copy  |f Restrictions unspecified  |2 star  |5 MiAaHDL 
533 |a Electronic reproduction.  |b [Place of publication not identified] :  |c HathiTrust Digital Library,  |d 2010.  |5 MiAaHDL 
538 |a Master and use copy. Digital master created according to Benchmark for Faithful Digital Reproductions of Monographs and Serials, Version 1. Digital Library Federation, December 2002.  |u http://purl.oclc.org/DLF/benchrepro0212  |5 MiAaHDL 
583 1 |a digitized  |c 2010  |h HathiTrust Digital Library  |l committed to preserve  |2 pda  |5 MiAaHDL 
505 0 |a Cover -- Preface -- Contents -- 1. Executive Summary and Recommendations -- 1.1 Why Is Extrapolation Still Required? -- 1.2 Summary of Findings -- 1.2.1 Historical Aspects -- 1.2.2 Neoplastic Disease -- 1.2.3 Somatic Genetic Damage at Molecular and Cellular Levels -- 1.2.4 Extrapolation Models and Methods -- 1.3 Conclusions -- 1.4 Recommendations -- 2. Introduction -- 3. History of Extrapolation: Nonhuman Experimental Systems to Humans -- 3.1 Introduction -- 3.2 Lessons Learned from Genetic Risks -- 3.2.1 Methods of Estimation 
505 8 |a 3.2.2 Discussion of Methods of Estimating Genetic Risk3.2.3 Role of Genetics in the Estimation of Somatic Risks -- 3.3 Somatic Risks -- 4. Tissue and Organ Differences Among Species with Emphasis on the Cells of Origin of Cancers -- 4.1 Introduction -- 4.2 Hematopoietic System -- 4.2.1 Introduction: Leukemias and Lymphomas -- 4.2.2 Comparison of Radiation-Induced Leukemias Among Species -- 4.2.3 Pathology and Dose-Response Relationships -- 4.2.4 Comparison of Hematopoietic Systems -- 4.2.5 Target Cells 
505 8 |a ""4.2.6 Comparison of Cytogenetic Processes: Common or Species-Specific Patterns""""4.2.7 Leukemogenesis Resulting from Gene Rearrangements""; ""4.2.8 Secondary Cytogenetic Lesions Associated with Leukemia Promotion and Progression""; ""4.2.9 Hematopoietic Cell Origins of the Putative “Criticalâ€? Genic Lesions and the Nature of Induced Genic Dysfunctions""; ""4.2.10 Cooperating Oncogenes in Lymphoid Neoplasias""; ""4.2.11 Cooperating Oncogenes in Myeloid Neoplasias""; ""4.2.12 Hematopoeitic Microenvironment""; ""4.2.13 Summary""; ""4.3 Lung""; ""4.3.1 Introduction"" 
505 8 |a 4.3.2 Adenocarcinoma4.3.3 Squamous-Cell Carcinoma -- 4.3.4 Small-Cell Lung Carcinoma -- 4.3.5 Large-Cell Carcinoma -- 4.3.6 Summary -- 4.4 Breast -- 4.4.1 Histogenesis of Mammary Glands and Mammary Cancer -- 4.4.2 Hormones and Mammary Carcinogenesis -- 4.4.3 Cellular Origins of Mammary Cancer -- 4.4.4 Summary -- 4.5 Thyroid -- 4.5.1 General Background -- 4.5.2 Histogenesis of the Thyroid Gland and Thyroid Cancer -- 4.5.3 Thyroid Function and its Control -- 4.5.4 Cellular Economy of the Thyroid Gland and the Origin of Cancer -- 4.5.5 Summary -- 4.6 Skin 
505 8 |a 4.6.1 Introduction4.6.2 Epidermal Cancers -- 4.6.3 Melanoma -- 4.6.4 Tumors of the Dermis -- 4.6.5 Mechanisms of Epidermal Carcinogenesis -- 4.6.6 Importance of Interactions -- 4.6.7 Summary -- 4.7 Gastrointestinal Tract -- 4.7.1 Introduction -- 4.7.2 Stomach -- 4.7.3 Small Intestine -- 4.7.4 Colorectal Tumors -- 4.7.5 Summary -- 4.8 Bone -- 4.8.1 Humans -- 4.8.2 Mice -- 4.8.3 Rats -- 4.8.4 Dogs -- 4.8.5 Summary -- 5. Radiation Effects at the Molecular and Cellular Levels -- 5.1 Introduction 
590 |a Knovel  |b ACADEMIC - Safety & Industrial Hygiene 
650 0 |a Radiation carcinogenesis. 
650 0 |a Radiation  |x Toxicology. 
650 0 |a Animal models in research. 
650 0 |a Carcinogenicity testing. 
650 0 |a Diseases  |x Animal models. 
650 1 2 |a Neoplasms, Radiation-Induced 
650 2 2 |a Carcinogenicity Tests 
650 2 2 |a Disease Models, Animal 
650 2 2 |a Neoplasms, Experimental  |x chemically induced 
650 6 |a Tumeurs dues aux radiations. 
650 6 |a Rayonnement  |x Toxicologie. 
650 6 |a Modèles animaux dans la recherche. 
650 6 |a Cancérogénicité. 
650 6 |a Maladies  |x Modèles animaux. 
650 7 |a MEDICAL  |x Oncology.  |2 bisacsh 
650 7 |a HEALTH & FITNESS  |x Diseases  |x Cancer.  |2 bisacsh 
650 7 |a Diseases  |x Animal models  |2 fast 
650 7 |a Carcinogenicity testing  |2 fast 
650 7 |a Animal models in research  |2 fast 
650 7 |a Radiation carcinogenesis  |2 fast 
650 7 |a Radiation  |x Toxicology  |2 fast 
710 2 |a National Council on Radiation Protection and Measurements. 
776 0 8 |i Print version:  |t Extrapolation of radiation-induced cancer risks from nonhuman experimental systems to humans.  |d Bethesda, MD : National Council on Radiation Protection and Measurements, ©2005  |z 092960086X  |w (DLC) 2005031014  |w (OCoLC)62152910 
830 0 |a NCRP report ;  |v no. 150. 
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