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The Construction of Analogy-Based Research Programs : the Lock-and-Key Analogy in 20th Century Biochemistry.
When the German chemist Emil Fischer presented his key-lock hypothesis in 1899, his analogy to describe the molecular relationship between enzymes and substrates quickly gained vast influence and provided future generations of scientists with a tool to investigate the relation between chemical struc...
| Clasificación: | Libro Electrónico |
|---|---|
| Autor principal: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Bielefeld :
Transcipt Verlag,
2019.
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| Colección: | Science studies.
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| Temas: | |
| Acceso en línea: | Texto completo |
MARC
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| 100 | 1 | |a Mertens, Rebecca. | |
| 245 | 1 | 4 | |a The Construction of Analogy-Based Research Programs : |b the Lock-and-Key Analogy in 20th Century Biochemistry. |
| 260 | |a Bielefeld : |b Transcipt Verlag, |c 2019. | ||
| 300 | |a 1 online resource (225 pages) | ||
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| 505 | 0 | |a Cover; Table of contents; Preface; 1 The lock-and-key analogy and its influence on 20th century biochemistry; 2 The lock-and-key analogy in Emil Fischer's program on sugar fermentation, 1890-1907; 3 The making of the lock-and-key model of the antibody-antigen relationship, 1886-1930; 4 Lock-and-key foundations for molecular biology: Linus Pauling and the Caltech group, 1930-1960; 5 Lock-and-key-based modeling and its influence on the development of biochemical research programs; 6 Concluding remarks on the construction of analogy-based research programs; Literature | |
| 520 | |a When the German chemist Emil Fischer presented his key-lock hypothesis in 1899, his analogy to describe the molecular relationship between enzymes and substrates quickly gained vast influence and provided future generations of scientists with a tool to investigate the relation between chemical structure and biological specificity. Rebecca Mertens explains the appeal of the lock-and-key analogy by its role in model building and in the construction of long-term, cross-generational research programs. She argues that a crucial feature of these research programs, namely ascertaining the continuity of core ideas and concepts, is provided by a certain way of analogy-based modelling. | ||
| 506 | 1 | |a Legal Deposit; |c Only available on premises controlled by the deposit library and to one user at any one time; |e The Legal Deposit Libraries (Non-Print Works) Regulations (UK). |5 WlAbNL | |
| 546 | |a In English. | ||
| 590 | |a JSTOR |b Books at JSTOR All Purchased | ||
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| 650 | 0 | |a History. | |
| 650 | 0 | |a History of Science. | |
| 650 | 0 | |a Medicine. | |
| 650 | 0 | |a Science |x Social aspects. | |
| 650 | 0 | |a Life sciences. | |
| 650 | 0 | |a Science |x Philosophy. | |
| 650 | 0 | |a Biochemistry. | |
| 650 | 0 | |a Analogy. | |
| 650 | 0 | |a Research Program. | |
| 650 | 0 | |a Molecular biology. | |
| 650 | 0 | |a Mathematical models. | |
| 650 | 0 | |a Medicine |x History |y 18th century. | |
| 650 | 1 | 2 | |a Biochemical Phenomena |
| 650 | 1 | 2 | |a Research |x history |
| 650 | 2 | 2 | |a Models, Theoretical |
| 650 | 2 | 2 | |a History, 19th Century |
| 650 | 2 | 2 | |a History, 18th Century |
| 650 | 2 | |a History | |
| 650 | 2 | |a Medicine | |
| 650 | 2 | |a Biological Science Disciplines | |
| 650 | 2 | |a Biochemistry | |
| 650 | 2 | |a Molecular Biology | |
| 650 | 6 | |a Histoire. | |
| 650 | 6 | |a Médecine. | |
| 650 | 6 | |a Sciences |x Aspect social. | |
| 650 | 6 | |a Sciences de la vie. | |
| 650 | 6 | |a Biochimie. | |
| 650 | 6 | |a Analogie (Philosophie) | |
| 650 | 6 | |a Biologie moléculaire. | |
| 650 | 6 | |a Modèles mathématiques. | |
| 650 | 6 | |a Médecine |x Histoire |y 19e siècle. | |
| 650 | 6 | |a Médecine |x Histoire |y 18e siècle. | |
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| 650 | 7 | |a biochemistry. |2 aat | |
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| 650 | 7 | |a molecular biology. |2 aat | |
| 650 | 7 | |a mathematical models. |2 aat | |
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| 650 | 7 | |a HISTORY / General |2 bisacsh | |
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| 650 | 7 | |a Analogy. |2 fast |0 (OCoLC)fst00808308 | |
| 650 | 7 | |a Biochemistry. |2 fast |0 (OCoLC)fst00831961 | |
| 650 | 7 | |a History. |2 fast |0 (OCoLC)fst00958235 | |
| 650 | 7 | |a Life sciences. |2 fast |0 (OCoLC)fst00998323 | |
| 650 | 7 | |a Medicine. |2 fast |0 (OCoLC)fst01014893 | |
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| 776 | 0 | 8 | |i Print version: |a Mertens, Rebecca. |t Construction of Analogy-Based Research Programs : The Lock-and-Key Analogy in 20th Century Biochemistry. |d Bielefeld : Transcipt Verlag, ©2019 |z 9783837644425 |
| 830 | 0 | |a Science studies. | |
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