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Viruses : agents of evolutionary invention /
Viruses are the most abundant biological entities on Earth, and arguably the most successful. They are not technically alive, but--as infectious vehicles of genetic information--they have a remarkable capacity to invade, replicate, and evolve within living cells. Synthesizing a large body of recent...
| Clasificación: | Libro Electrónico |
|---|---|
| Autor principal: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Cambridge, Massachusetts :
Harvard University Press,
2017.
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| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- 1. Obligate parasites of cells: Discovery
- The virosphere and its metagenome
- Complexity and "dark matter"
- Selfish information and the essence of being viral
- The emergence of egotistical replicators
- The viral empire
- 2. Viruses, genes, and ecosystems: Lifestyles and life cycles
- Lysogeny: exercising temperance
- Kill the winner
- Gene brokers
- Selfishness driving adaptive evolution
- Phages and the microbiome
- Unfriendly competition
- Chemical warfare
- 3. Potentiation of bacterial diseases by phages: For a charm of powerful trouble
- Toxic enablers
- Choose your poison
- Treasure islands
- Prophage induction and antibiotic drug resistance
- 4. Viruses and higher organisms: Viruses, cells, organisms, and populations
- "Just a virus"
- Human rhinoviruses
- Uncommon diversity
- Accidents of pathogenesis
- Mutation, diversity, and quasipecies
- 5. The flu: no common cold: Antigenic escape artists
- Human influenza a virus
- Epidemic influenza: dress for the season
- Quasispecies, sequence clusters, and codon bias
- Correlating genetic and antigenic evolution
- Seeding of seasonal epidemics
- Pandemic influenza: the emperor with no clothes
- 6. Alternative virus lifestyles: Latency: 'til death do us part
- All in the family Herpesviridae
- 7. Evolutionary mechanisms of DNA viruses: Gene duplication and gene capture
- Poxvirus evolution
- Poxvirus party tricks
- Small DNA virus evolution
- 8. Viroids and megaviruses: extremes: Viroids: the smallest
- Evolutionary reliquary
- Megaviruses: the biggest
- Big and bigger
- Virophages: fleas upon fleas
- Chimerism
- Megavirus origins: mavericks at heart
- 10. HIV-1: a very modern pandemic: A new disease and a new virus
- Anatomy of HIV-1
- HIV in the making
- Socioepidemiology of AIDS: a man-made epidemic
- Within-host evolution: a very personal arms race
- Short-sighted evolution
- Adaptive evolution: an evolving relationship
- Outrunning the red queen
- Medicine at the virus-host interface
- Resistance is futile
- 10. Cross-species infections: means and opportunity: A rogue's gallery of emerging viruses
- Adaptive evolution in zoonosis
- Fitness landscape
- A shifting fitness landscape
- The paradox in RNA virus evolution
- RNA viruses and molecular clocks
- Arboviruses: vector-borne viruses
- Evolutionary compromise
- Host restriction
- 11. Future pandemic influenza: enemy at the gates: Real and present danger
- Pandemic threat level
- The pandemic phenotype
- Outbreak
- 12. Ebolavirus: EBOV Makona
- What we were afraid to say about Ebola
- Evolution or adaptive change
- EBOV persistence
- 13. Viral zoonoses and animal reservoirs: The usual suspects
- Filovirus origins
- Bats and viral zoonoses
- A special relationship
- Tolerance and resistance
- 14. Endogenous retroviruses: our viral heritage: Genome invasion by retroviruses
- Endogenization in progress
- Change agents
- Domestication of ERV genes
- Endogenous viral elements
- 15. Viruses as human tools: Myxoma virus: biological control
- Genomics of an attenuated poxvirus
- Orthopoxviruses: past solutions and future problems
- Live-attenuated viruses
- Attenuation by design
- Virus therapeutics
- Doctor's little helpers
- Oncolytic viruses
- 16. Humanity and viruses: The human future and viruses
- Beauty in design.