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Junk DNA : a journey through the dark matter of the genome /
For decades after identifying the structure of DNA, scientists focused only on genes, the regions of the genome that contain codes for the production of proteins. Other regions that make up 98% of the human genome were dismissed as "junk," sequences that serve no purpose. Yet recently rese...
| Clasificación: | Libro Electrónico |
|---|---|
| Autor principal: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
New York :
Columbia University Press,
2015.
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| Temas: | |
| Acceso en línea: | Texto completo |
MARC
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| 100 | 1 | |a Carey, Nessa, |e author. | |
| 245 | 1 | 0 | |a Junk DNA : |b a journey through the dark matter of the genome / |c Nessa Carey. |
| 260 | |a New York : |b Columbia University Press, |c 2015. | ||
| 300 | |a 1 online resource | ||
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| 504 | |a Includes bibliographical references and index. | ||
| 588 | 0 | |a Print version record. | |
| 505 | 0 | 0 | |t Frontmatter -- |t Contents -- |t Acknowledgments -- |t Notes on Nomenclature -- |t An Introduction to Genomic Dark Matter -- |t 1. Why Dark Matter Matters -- |t 2. When Dark Matter Turns Very Dark Indeed -- |t 3. Where Did All the Genes Go? -- |t 4. Outstaying an Invitation -- |t 5. Everything Shrinks When We Get Old -- |t 6. Two Is the Perfect Number -- |t 7. Painting with Junk -- |t 8. Playing the Long Game -- |t 9. Adding Colour to the Dark Matter -- |t 10. Why Parents Love Junk -- |t 11. Junk with a Mission -- |t 12. Switching It On, Turning It Up -- |t 13. No Man's Land -- |t 14. Project ENCODE -- Big Science Comes to Junk DNA -- |t 15. Headless Queens, Strange Cats and Portly Mice -- |t 16. Lost in Untranslation -- |t 17. Why LEGO is Better Than Airfix -- |t 18. Mini Can Be Mighty -- |t 19. The Drugs Do Work (Sometimes) -- |t 20. Some Light in the Darkness -- |t Notes -- |t Appendix: Human Diseases Cited in the Main Text, in Which Junk DNA Has Been Implicated -- |t Index. |
| 520 | |a For decades after identifying the structure of DNA, scientists focused only on genes, the regions of the genome that contain codes for the production of proteins. Other regions that make up 98% of the human genome were dismissed as "junk," sequences that serve no purpose. Yet recently researchers have discovered variations and modulations in this junk DNA that underwrite a number of intractable diseases. This knowledge has led to innovative research and treatment approaches that may finally control these conditions. Junk DNA can play vital and unanticipated roles in the control of gene expression, from fine-tuning individual genes to switching off entire chromosomes. Its function has forced scientists to revisit the very meaning of the word "gene" and has engendered a bitter battle over whether or not this genomic "nonsense" is the source of human biological complexity. Drawing on her experience with leading investigators in Europe and North America, Nessa Carey provides a clear and compelling introduction to junk DNA and its critical involvement in phenomena as diverse as genetic diseases, viral infections, sex determination in mammals, disease treatments, and evolution. We are only now unlocking the secrets of junk DNA, and Carey's book is an indispensable resource for navigating the codes and controversies of this fast-growing and hotly disputed field. | ||
| 546 | |a In English. | ||
| 590 | |a JSTOR |b Books at JSTOR Demand Driven Acquisitions (DDA) | ||
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| 776 | 0 | 8 | |i Print version: |a Carey, Nessa. |t Junk DNA : A Journey Through the Dark Matter of the Genome. |d New York : Columbia University Press, ©2015 |z 9780231170840 |
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