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Sequence alignment : methods, models, concepts, and strategies /
The sequencing of the human genome involved thousands of scientists but used relatively few tools. Today, obtaining sequences is simpler, but aligning the sequences-making sure that sequences from one source are properly compared to those from other sources-remains a complicated but underappreciated...
| Clasificación: | Libro Electrónico |
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| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Berkeley :
University of California Press,
©2009.
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| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Sequence alignment : concepts and history
- Insertion and deletion events, their molecular mechanisms, and their impact on sequence alignments
- Local versus global alignments
- Computing multiple sequence alignment with template-based methods
- Sequence evolution models for simultaneous alignment and phylogeny reconstruction
- Phylogenetic hypotheses and the utility of multiple sequence alignment
- Structural and evolutionary considerations for multiple sequence alignment of RNA, and the challenges for algorithms that ignore them
- Constructing alignment benchmarks
- Simulation approaches to evaluating alignment error and methods for comparing alternate alignments
- Robust inferences from ambiguous alignments
- Strategies for efficient exploitation of the informational content of protein multiple alignments.